(Q40820073)

24 September 2017

title

Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor (English)

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24 September 2017

Haskell-Luevano C

1

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24 September 2017

Monck EK

series ordinal

2

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24 September 2017

publication date

1 May 2001

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24 September 2017

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24 September 2017

volume

99

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24 September 2017

issue

1

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24 September 2017

page(s)

1-7

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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

24 September 2017

cites work

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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

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The mouse mahogany locus encodes a transmembrane form of human attractin

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The mahogany protein is a receptor involved in suppression of obesity

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7 January 2021

Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.

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The cloning of a family of genes that encode the melanocortin receptors

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7 January 2021

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system

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7 January 2021

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

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7 January 2021

Molecular cloning, expression, and characterization of a fifth melanocortin receptor

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7 January 2021

Molecular characterization of the mouse agouti locus.

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7 January 2021

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation

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7 January 2021

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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7 January 2021

Characterization of Agouti-related protein binding to melanocortin receptors

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7 January 2021

Overexpression of Agrt leads to obesity in transgenic mice.

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7 January 2021

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

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7 January 2021

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

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7 January 2021

A frameshift mutation in human MC4R is associated with a dominant form of obesity

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7 January 2021

A frameshift mutation in MC4R associated with dominantly inherited human obesity

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7 January 2021

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

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7 January 2021

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

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7 January 2021

Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.

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7 January 2021

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

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7 January 2021

Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat

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7 January 2021

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

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7 January 2021

Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues.

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7 January 2021

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

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7 January 2021

Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics

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7 January 2021

Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade

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7 January 2021

A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathways

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7 January 2021

A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor.

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7 January 2021

Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

1 reference

https://api.crossref.org/works/10.1016%2FS0167-0115%2801%2900234-8

7 January 2021

Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions

1 reference

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7 January 2021

Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats

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7 January 2021

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior

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7 January 2021

A receptor subtype involved in neuropeptide-Y-induced food intake

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7 January 2021

Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-0115%2801%2900234-8

7 January 2021

Switching agonist/antagonist properties of opiate alkaloids at the delta opioid receptor using mutations based on the structure of the orphanin FQ receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-0115%2801%2900234-8

7 January 2021

AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-0115%2801%2900234-8

7 January 2021

10.1016/S0167-0115(01)00234-8

Identifiers

DOI

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24 September 2017

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