(Q40832497)

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Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor

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scholarly article

1 reference

Europe PubMed Central

24 September 2017

Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor (English)

1 reference

Europe PubMed Central

24 September 2017

G protein-coupled receptor

0 references

Hans Bräuner-Osborne

5

1 reference

Europe PubMed Central

24 September 2017

author name string

Jensen AA

1

1 reference

Europe PubMed Central

24 September 2017

Sheppard PO

2

1 reference

Europe PubMed Central

24 September 2017

Jensen LB

3

1 reference

Europe PubMed Central

24 September 2017

O'Hara PJ

4

1 reference

Europe PubMed Central

24 September 2017

language of work or name

0 references

publication date

22 December 2000

1 reference

Europe PubMed Central

24 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

24 September 2017

276

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Europe PubMed Central

24 September 2017

13

1 reference

Europe PubMed Central

24 September 2017

10110-10118

1 reference

Europe PubMed Central

24 September 2017

Ligands for glutamate receptors: design and therapeutic prospects

1 reference

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21 January 2018

Physiology and pathophysiology of the extracellular calcium-sensing receptor

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Molecular aspects of pheromonal communication via the vomeronasal organ of mammals.

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Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor

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Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain

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21 January 2018

Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C).

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21 January 2018

Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity.

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21 January 2018

New perspectives for the development of selective metabotropic glutamate receptor ligands.

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21 January 2018

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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21 January 2018

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

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21 January 2018

Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1.

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21 January 2018

Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor

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21 January 2018

The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

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21 January 2018

Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor

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21 January 2018

Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding

1 reference

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21 January 2018

Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor

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21 January 2018

Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes

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21 January 2018

The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity

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Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

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Functional expression and properties of the human skeletal muscle sodium channel

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Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling

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Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

1 reference

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21 January 2018

The design of metal-binding sites in proteins

1 reference

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21 January 2018

Analysis of zinc binding sites in protein crystal structures

1 reference

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Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

1 reference

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21 January 2018

Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1.

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21 January 2018

Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluR1 alpha and mGluR5) in the cat visual cortex before, during, and after the peak of the critical period for eye-specific connections.

1 reference

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21 January 2018

Rapid internalization and surface expression of a functional, fluorescently tagged G-protein-coupled glutamate receptor

1 reference

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21 January 2018

Cys-140 is critical for metabotropic glutamate receptor-1 dimerization

1 reference

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21 January 2018

Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys --> Ser mutations at Cys101 and Cys236.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007220200

21 January 2018

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.

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21 January 2018

Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors

1 reference

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21 January 2018

Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors.

1 reference

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21 January 2018

Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor

1 reference

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21 January 2018

Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation

1 reference

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21 January 2018

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

1 reference

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21 January 2018

Geometry of interaction of metal ions with histidine residues in protein structures

1 reference

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21 January 2018

Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity

1 reference

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21 January 2018

Protein design: novel metal-binding sites

1 reference

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21 January 2018

Structure of an engineered, metal-actuated switch in trypsin

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21 January 2018

Structural consequences of redesigning a protein-zinc binding site

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21 January 2018

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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21 January 2018

Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists

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Calcimimetics with potent and selective activity on the parathyroid calcium receptor

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The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain

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21 January 2018

GABAB receptors make it to the top--as dimers

1 reference

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21 January 2018

The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

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21 January 2018

Metabotropic glutamate receptor 5 is a disulfide-linked dimer

1 reference

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21 January 2018

Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors

1 reference

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21 January 2018

Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

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21 January 2018

A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor

1 reference

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21 January 2018

Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites

1 reference

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21 January 2018

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

1 reference

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21 January 2018

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M007220200

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

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