(Q40839002)

English

Aliphatic Halogenase Enables Late-Stage C-H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity

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Europe PubMed Central

PubMed publication ID

24 September 2017

Aliphatic Halogenase Enables Late-Stage C-H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

12-epi-fischerindole G

1 reference

ChEBI release 2020-05-28

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Matthew L. Hillwig

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Xinyu Liu

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

8 January 2016

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Europe PubMed Central

PubMed publication ID

24 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

17

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

6

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

466-470

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749394%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Beyond C, H, O, and N! Analysis of the elemental composition of U.S. FDA approved drug architectures

1 reference

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21 January 2018

Fluorine in pharmaceuticals: looking beyond intuition

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Halogen bond: its role beyond drug-target binding affinity for drug discovery and development

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica

1 reference

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Expanding P450 catalytic reaction space through evolution and engineering

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Manganese porphyrins catalyze selective C-H bond halogenations

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.

1 reference

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21 January 2018

Biosynthesis of (-)-(1S,2R)-allocoronamic acyl thioester by an Fe(II)-dependent halogenase and a cyclopropane-forming flavoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Metamorphic enzyme assembly in polyketide diversification

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.

1 reference

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21 January 2018

Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Identification and characterization of a welwitindolinone alkaloid biosynthetic gene cluster in the stigonematalean Cyanobacterium Hapalosiphon welwitschii.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

A new family of iron-dependent halogenases acts on freestanding substrates.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Gene expression enabling synthetic diversification of natural products: chemogenetic generation of pacidamycin analogs

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500674

21 January 2018

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