(Q40848684)

24 September 2017

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title

Transgenic assays for mutations and cancer: current status and future perspectives (English)

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24 September 2017

Vijg J

1

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24 September 2017

van Steeg H

series ordinal

2

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24 September 2017

language of work or name

English

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publication date

1 May 1998

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24 September 2017

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24 September 2017

volume

400

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24 September 2017

issue

1-2

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24 September 2017

page(s)

337-354

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A genetic model for colorectal tumorigenesis

24 September 2017

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Do short-term tests predict rodent carcinogenicity?

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Carcinogenesis. Testing times for the tests.

7 January 2021

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Mitogenesis is only one factor in carcinogenesis.

7 January 2021

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Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

7 January 2021

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Reevaluation of the mutagenicity and carcinogenicity of chemicals previously identified as "false positives" in the Salmonella typhimurium mutagenicity assay

7 January 2021

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Transgenic mice as models for tumorigenesis

7 January 2021

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Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice

7 January 2021

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Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.

7 January 2021

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Short-term carcinogenicity testing of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in E(mu)-pim-1 transgenic mice

7 January 2021

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Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM transgenic mice

7 January 2021

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v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid

7 January 2021

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Association of tumor development with increased cellular proliferation and transgene overexpression, but not c-Ha-ras mutations, in v-Ha-ras transgenic Tg.AC mice

7 January 2021

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Kinetics of wound-induced v-Ha-ras transgene expression and papilloma development in transgenic Tg.AC mice

7 January 2021

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Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models

7 January 2021

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Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice

7 January 2021

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Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors.

7 January 2021

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p53, the cellular gatekeeper for growth and division

7 January 2021

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 January 2021

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Tumor spectrum analysis in p53-mutant mice

7 January 2021

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

7 January 2021

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Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

7 January 2021

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The p53-deficient mouse: a model for basic and applied cancer studies

7 January 2021

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Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

7 January 2021

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

7 January 2021

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Hepatocarcinogenesis in p53-deficient mice

7 January 2021

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Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.

7 January 2021

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The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

7 January 2021

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Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?

7 January 2021

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

7 January 2021

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Atm-deficient mice: a paradigm of ataxia telangiectasia

7 January 2021

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Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53.

7 January 2021

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Requirement for a functional Rb-1 gene in murine development

7 January 2021

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Effects of an Rb mutation in the mouse

7 January 2021

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Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

7 January 2021

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Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

7 January 2021

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Mechanisms of DNA excision repair

7 January 2021

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Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain

7 January 2021

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Cloning and characterization of the mouse XPAC gene

7 January 2021

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Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

7 January 2021

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High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

7 January 2021

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High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.

7 January 2021

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Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

7 January 2021

1 reference

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Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

7 January 2021

1 reference

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Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

7 January 2021

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DNA damages processed by base excision repair: biological consequences

7 January 2021

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

7 January 2021

1 reference

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Mismatch repair, genetic stability, and cancer

7 January 2021

1 reference

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

7 January 2021

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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Evidence that mammalian cells possess homologous recombinational repair pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Mutation cytogenetics: past, present and future

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Transgenic mice as model systems for studying gene mutations in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Transgenic Animal Models for Detection of In Vivo Mutations

7 January 2021

1 reference

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E. coli C: a convenient host strain for rescue of highly methylated DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Development of a short-term, in vivo mutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

The use of selection in recovery of transgenic targets for mutation analysis

7 January 2021

1 reference

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Overview of mutation assays in transgenic mice for routine testing

7 January 2021

1 reference

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Use of phi X174 as a shuttle vector for the study of in vivo mammalian mutagenesis

7 January 2021

1 reference

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Frequent spontaneous deletions at a shuttle vector locus in transgenic mice

7 January 2021

1 reference

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High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome

7 January 2021

1 reference

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Application of galactose-sensitiveE.colistrains as selective hosts for LacZ−plasmids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Plasmid-based transgenic mouse model for studying in vivo mutations

7 January 2021

1 reference

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Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations.

7 January 2021

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A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice

7 January 2021

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Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU‐treated big blue™ B6C3F1 mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

In vivo human somatic mutation: frequency and spectrum with age

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Mutation frequency in human blood cells increases with age

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Somatic mutations in the brain: relationship to aging?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Reporter genes in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Conditional transgene expression in the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Organ distinctive mutagenicity in MutaMouse after short-term exposure to PhIP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Environment and cancer: who are susceptible?

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

International Commission for Protection Against Environmental Mutagens and Carcinogens. A method for comparing and combining short-term genotoxicity test data: the basic system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Mutagenesis and transgenic systems: perspective from the mutagen, N-ethyl-N-nitrosourea

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Cancer prevention, rodent high-dose cancer tests, and risk assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900030-X

Genetic testing: the problems and the promise

7 January 2021

1 reference

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10.1016/S0027-5107(98)00030-X

7 January 2021

Identifiers

DOI

1 reference

24 September 2017

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