(Q40853467)

English

Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.

scientific article published on December 2000

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10 November 2019

Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2 (English)

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10 November 2019

Paul D. Soloway

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10 November 2019

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10 November 2019

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Toth M

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10 November 2019

Bernardo MM

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10 November 2019

Gervasi DC

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10 November 2019

Wang Z

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10 November 2019

Bigg HF

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10 November 2019

Overall CM

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10 November 2019

Tschesche H

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Cher ML

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10 November 2019

Brown S

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10 November 2019

Mobashery S

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10 November 2019

Fridman R

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1 December 2000

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10 November 2019

Journal of Biological Chemistry

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10 November 2019

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10 November 2019

41415-41423

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10 November 2019

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10 November 2019

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A matrix metalloproteinase expressed on the surface of invasive tumour cells

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Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP.

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Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage

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Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family

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21 January 2018

Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

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Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity

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Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases

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Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules

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Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

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Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins

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Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro

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Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3.

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Matrix metalloproteinases. Novel targets for directed cancer therapy

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Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat

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21 January 2018

The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study

1 reference

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21 January 2018

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

1 reference

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21 January 2018

Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)

1 reference

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21 January 2018

Analysis of tissue inhibitor of metalloproteinases-2 effect on pro-matrix metalloproteinase-2 activation by membrane-type 1 matrix metalloproteinase using baculovirus/insect-cell expression system

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21 January 2018

Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.

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21 January 2018

Clinical potential of matrix metalloprotease inhibitors

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Marimastat (BB2516): current status of development

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The next generation of MMP inhibitors. Design and synthesis

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Matrix metalloproteinase inhibitors in the treatment of cancer

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Production of homozygous mutant ES cells with a single targeting construct

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Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes

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21 January 2018

Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme

1 reference

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21 January 2018

The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2.

1 reference

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21 January 2018

Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.

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21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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21 January 2018

TIMP-2 is required for efficient activation of proMMP-2 in vivo

1 reference

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21 January 2018

Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation

1 reference

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21 January 2018

Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2

1 reference

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21 January 2018

The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.

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21 January 2018

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

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Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

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Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence

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10.1074/JBC.M006871200

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Europe PubMed Central

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10 November 2019

1 reference

Europe PubMed Central

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10 November 2019

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