(Q40853538)

24 September 2017

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title

DNA topoisomerase I and II in cancer chemotherapy: update and perspectives. (English)

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24 September 2017

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Y Pommier

1

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24 September 2017

1 January 1993

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Cancer Chemotherapy and Pharmacology

24 September 2017

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24 September 2017

32

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24 September 2017

103-108

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24 September 2017

2

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https://scigraph.springernature.com/pub.10.1007/bf00685611

24 September 2017

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cites work

Recent studies of DNA topoisomerases.

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Crossref

https://api.crossref.org/works/10.1007%2FBF00685611

Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination.

21 January 2018

1 reference

12 December 2020

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1 reference

12 December 2020

Effect of 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants.

1 reference

12 December 2020

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs.

1 reference

12 December 2020

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1 reference

12 December 2020

Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene

1 reference

12 December 2020

Acidic phospholipids directly inhibit DNA binding of mammalian DNA topoisomerase I.

1 reference

12 December 2020

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1 reference

12 December 2020

Progressive resistance to doxorubicin in mouse leukemia L1210 cells with multidrug resistance phenotype: reductions in drug-induced topoisomerase II-mediated DNA cleavage.

1 reference

12 December 2020

Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA.

1 reference

12 December 2020

Supercoiling of intracellular DNA can occur in eukaryotic cells.

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12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

12 December 2020

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

1 reference

12 December 2020

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

1 reference

12 December 2020

Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.

1 reference

12 December 2020

Characterization of a camptothecin-resistant human DNA topoisomerase I

1 reference

12 December 2020

DNA topoisomerase poisons as antitumor drugs.

1 reference

12 December 2020

Inhibition of human immunodeficiency virus (HIV-1) replication in vitro by noncytotoxic doses of camptothecin, a topoisomerase I inhibitor

1 reference

12 December 2020

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment

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12 December 2020

Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues

1 reference

12 December 2020

Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino)methanesulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase II in a murine mastocytoma cell line

1 reference

12 December 2020

Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA.

1 reference

12 December 2020

Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin

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12 December 2020

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

1 reference

12 December 2020

Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide

1 reference

12 December 2020

Protein-linked DNA strand breaks produced by etoposide and teniposide in mouse L1210 and human VA-13 and HT-29 cell lines: relationship to cytotoxicity

1 reference

12 December 2020

Topoisomerase I interaction with SV40 DNA in the presence and absence of camptothecin

1 reference

12 December 2020

10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells.

1 reference

12 December 2020

Cell death induced by topoisomerase inhibitors. Role of calcium in mammalian cells.

1 reference

12 December 2020

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1 reference

12 December 2020

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1 reference

12 December 2020

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse

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12 December 2020

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

1 reference

12 December 2020

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts

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12 December 2020

Mode of action of the new quinolones: new data

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12 December 2020

E-ring desoxy analogues of etoposide

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12 December 2020

Disassembly of the nucleus in mitotic extracts: membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes

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12 December 2020

Stimulation of the topoisomerase II induced DNA cleavage sites in the c-myc protooncogene by antitumor drugs is associated with gene expression

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12 December 2020

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

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12 December 2020

DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

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12 December 2020

Teniposide, a topoisomerase II inhibitor, prevents chromosome condensation and separation but not decondensation in fertilized surf clam (Spisula solidissima) oocytes.

1 reference

12 December 2020

Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines

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12 December 2020

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

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12 December 2020

Topoisomerase I-mediated integration of hepadnavirus DNA in vitro

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12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

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12 December 2020

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

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12 December 2020

Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death.

1 reference

12 December 2020

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

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12 December 2020

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.

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12 December 2020

Purification and characterization of a type II DNA topoisomerase from bovine calf thymus.

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12 December 2020

Transcription generates positively and negatively supercoiled domains in the template.

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12 December 2020

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

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12 December 2020

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

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12 December 2020

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.

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12 December 2020

Induction of topoisomerase II gene expression in human lymphocytes upon phytohemagglutinin stimulation

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12 December 2020

Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells

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12 December 2020

DNA topoisomerases: why so many?

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12 December 2020

Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative

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12 December 2020

Purification and properties of type II DNA topoisomerase from embryos of Drosophila melanogaster

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12 December 2020

Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants

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12 December 2020

Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression

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12 December 2020

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12 December 2020

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

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12 December 2020

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II

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12 December 2020

The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells

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12 December 2020

Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.

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12 December 2020

Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

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12 December 2020

Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster.

1 reference

12 December 2020

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication

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12 December 2020

Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome.

1 reference

12 December 2020

DNA topoisomerases from rat liver: physiological variations

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12 December 2020

DNA topoisomerases as potential targets of antiviral action.

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12 December 2020

Characterization of the 3' region of the human DNA topoisomerase I gene.

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12 December 2020

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

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12 December 2020

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1 reference

12 December 2020

A homogeneous type II DNA topoisomerase from HeLa cell nuclei

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12 December 2020

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

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12 December 2020

DNA topoisomerase II is required at the time of mitosis in yeast

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12 December 2020

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.

1 reference

12 December 2020

High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients

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12 December 2020

Single-strand DNA cleavages by eukaryotic topoisomerase II

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12 December 2020

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

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12 December 2020

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

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12 December 2020

Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle.

1 reference

12 December 2020

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.

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12 December 2020

Phorbol ester effects on topoisomerase II activity and gene expression in HL-60 human leukemia cells with different proclivities toward monocytoid differentiation

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12 December 2020

Abrogation of etoposide-mediated cytotoxicity by cycloheximide.

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12 December 2020

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes

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12 December 2020

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

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12 December 2020

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

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12 December 2020

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle

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12 December 2020

Identifiers

DOI

10.1007/BF00685611

1 reference

PubMed ID

8387398

Dimensions Publication ID

24 September 2017

0 references

1 reference

PubMed ID

8387398