(Q40872524)

24 September 2017

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title

Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of agitated critically ill patients (English)

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24 September 2017

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Wagner BK

1

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24 September 2017

O'Hara DA

series ordinal

2

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24 September 2017

publication date

1 December 1997

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Clinical Pharmacokinetics

24 September 2017

published in

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24 September 2017

volume

33

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24 September 2017

issue

6

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24 September 2017

page(s)

426-453

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Disposition of alfentanil in burns patients

24 September 2017

cites work

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12 December 2020

Use of sedating drugs and neuromuscular blocking agents in patients requiring mechanical ventilation for respiratory failure. A national survey

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12 December 2020

Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects.

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12 December 2020

Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).

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12 December 2020

Pharmacokinetics and distribution properties of pentobarbital in humans following oral and intravenous administration

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of remifentanil in volunteer subjects with severe liver disease.

1 reference

12 December 2020

Propofol infusion for sedation of patients with head injury in intensive care. A preliminary report.

1 reference

12 December 2020

Lignocaine metabolite formation: an indicator for liver dysfunction and predictor of survival in surgical intensive care patients.

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12 December 2020

[Comparison of the pharmacokinetics of etomidate in children and in adults]

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12 December 2020

Pharmacokinetics of midazolam administered by continuous intravenous infusion to intensive care patients

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12 December 2020

Alterations in response to somatic pain associated with anaesthesia. II. The effect of thiopentone and pentobarbitone.

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12 December 2020

Effects of chloramphenicol on infusion pharmacokinetics of propofol in greyhounds.

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12 December 2020

Meperidine disposition in burn patients

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12 December 2020

Naloxone's effect on cognitive functioning in drug-free and diazepam-treated normal humans.

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12 December 2020

Pentobarbital elimination in patients with poor renal function

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12 December 2020

Pharmacokinetics of long-term propofol infusion used for sedation in ICU patients.

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12 December 2020

Premedication with oral and rectal diazepam

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12 December 2020

Impaired Lignocaine metabolism in patients with myocardial infarction and cardiac failure

1 reference

12 December 2020

Toxic effects of drugs used in the ICU. Antiarrhythmic agents.

1 reference

12 December 2020

Narcotic pharmacokinetics and dynamics: the basis of infusion applications.

1 reference

12 December 2020

Cardiovascular Effects of Meperidine-N2O Anesthesia Before and After Pancuronium

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12 December 2020

Effect of barbiturate therapy on phenytoin pharmacokinetics

1 reference

12 December 2020

Fentanyl and Sufentanil Increase Intracranial Pressure in Head Trauma Patients

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12 December 2020

Sufentanil pharmacokinetics in patients with cirrhosis.

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12 December 2020

Ventricular fluid pressure in neurosurgical patients receiving intravenous lorazepam for premedication

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12 December 2020

The Pharmacokinetics of Sufentanil in Surgical Patients

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12 December 2020

Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia

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12 December 2020

Pharmacokinetics of haloperidol in psychotic patients

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12 December 2020

Effects of model traumatic injury on hepatic drug metabolism in the rat. V. Sulfation and acetylation

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12 December 2020

Controlled study of extrapyramidal reactions in the management of delirious, medically ill patients: intravenous haloperidol versus intravenous haloperidol plus benzodiazepines

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12 December 2020

A potentially hazardous interaction between erythromycin and midazolam.

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12 December 2020

The protein binding of diazepam and N-demethyldiazepam in patients with poor renal function

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12 December 2020

Comparison of propofol and midazolam for sedation in critically ill patients.

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12 December 2020

Pharmacokinetics of benzodiazepine antagonist Ro 15-1788 in cirrhotic patients with moderate or severe liver dysfunction

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12 December 2020

Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital

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12 December 2020

Pharmacokinetics of low-dose intravenous pethidine in patients with renal dysfunction

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12 December 2020

Multiple-dose evaluation of intravenous hydromorphone pharmacokinetics in normal human subjects

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12 December 2020

Pharmacokinetics of continuous intravenous infusion of methadone in the early post-burn period

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12 December 2020

Clinical assessment of etomidate for outpatient general anesthesia: a preliminary evaluation.

1 reference

12 December 2020

Hexobarbitone disposition at different stages of intensive care treatment

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12 December 2020

Pharmacokinetics of propofol and its conjugates after continuous infusion in normal and in renal failure patients: a preliminary study.

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12 December 2020

The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.

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12 December 2020

Pharmacokinetics and effects on intracranial pressure of sufentanil in head trauma patients

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12 December 2020

Comparative study of propofol versus midazolam in the sedation of critically ill patients: results of a prospective, randomized, multicenter trial.

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12 December 2020

Patient-controlled analgesia: a new concept of postoperative pain relief

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12 December 2020

Pharmacokinetics of droperidol in surgical patients under different conditions of anaesthesia.

1 reference

12 December 2020

Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans

1 reference

12 December 2020

Safety and efficacy of continuous intravenous morphine for severe cancer pain

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12 December 2020

Cerebral metabolism during propofol anesthesia in humans studied with positron emission tomography

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12 December 2020

Glucuronidation of propofol in microsomal fractions from various tissues and species including humans: effect of different drugs.

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12 December 2020

Beyond the Ramsay scale: need for a validated measure of sedating drug efficacy in the intensive care unit

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12 December 2020

Absorption, Metabolism and Excretion of Droperidol by Human Subjects Folloiwing Intramuscular and Intravenous Administration

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12 December 2020

The effects of acute changes in renal function on the pharmacokinetics of midazolam during long-term infusion in ICU patients

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12 December 2020

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12 December 2020

Pharmacokinetic studies on haloperidol in man.

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12 December 2020

Pathophysiology and pharmacokinetics following burn injury

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12 December 2020

Cimetidine does not alter morphine disposition in man.

1 reference

12 December 2020

Clinical Depression of the Central Nervous System Due to Diazepam and Chlordiazepoxide in Relation to Cigarette Smoking and Age

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12 December 2020

Diazepam and intracranial pressure.

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12 December 2020

Continuous infusion of loop diuretics in the critically ill: a review of the literature.

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12 December 2020

Comparison of propofol and midazolam for sedation in intensive care unit patients.

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12 December 2020

The chronic pain syndrome: misconceptions and management

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12 December 2020

Metabolism of lorazepam

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12 December 2020

A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys

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12 December 2020

Psychotropic drugs in the treatment of chronic pain

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12 December 2020

The EEG as a monitor of sedation: encouraging progress

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12 December 2020

Accumulation of midazolam after repeated dosage in patients receiving mechanical ventilation in an intensive care unit

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12 December 2020

Continuous monitoring of depth of sedation by EEG spectral analysis in patients requiring mechanical ventilation.

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12 December 2020

Haloperidol kinetics after oral and intravenous doses

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12 December 2020

Acute pulmonary edema following naloxone reversal of high-dose morphine anesthesia

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12 December 2020

Alfentanil infusions in patients requiring intensive care

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12 December 2020

Pharmacokinetics of hydromorphone after intravenous, peroral and rectal administration to human subjects

1 reference

12 December 2020

EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil

1 reference

12 December 2020

Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU.

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12 December 2020

Propofol vs midazolam in short-, medium-, and long-term sedation of critically ill patients. A cost-benefit analysis.

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12 December 2020

Is sufentanil suitable for long-term sedation of a critically ill patient?

1 reference

12 December 2020

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain

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12 December 2020

Pharmacokinetic variability of midazolam infusions in critically ill patients.

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12 December 2020

The altered pharmacokinetics and pharmacodynamics of drugs commonly used in critically ill patients

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12 December 2020

Analgesia and sedation in intensive care

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12 December 2020

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

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12 December 2020

Cardiorespiratory effects of anaesthesia with morphine or fentanyl in chronic renal failure and cerebral toxicity after morphine

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12 December 2020

EEG and memory effects of low-dose infusions of propofol

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12 December 2020

Studies on morphine disposition: influence of renal failure on the kinetics of morphine and its metabolites

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12 December 2020

Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally induced acute pain

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12 December 2020

Clinical Pharmacokinetics of Oxazepam and Lorazepam

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12 December 2020

1 reference

12 December 2020

Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: association with myocardial hyporesponsiveness to catecholamines

1 reference

12 December 2020

Clinical Significance of Monitoring Plasma Levels of Psychotropic Drugs

1 reference

12 December 2020

Nalmefene: intravenous safety and kinetics of a new opioid antagonist

1 reference

12 December 2020

Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers

1 reference

12 December 2020

Urinary excretion of hydromorphone and metabolites in humans, rats, dogs, guinea pigs, and rabbits

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12 December 2020

Pharmacokinetics of haloperidol and reduced haloperidol in Chinese schizophrenic patients after intravenous and oral administration of haloperidol

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12 December 2020

Effects of aging and liver disease on disposition of lorazepam

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12 December 2020

Biochemical and Electrophysiologic Evidence That Propofol Enhances GABAergic Transmission in the Rat Brain

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12 December 2020

Low dose intravenous infusion technique with ketamine. Amnesic, analgesic and sedative effects in human volunteers.

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12 December 2020

Elimination half-life and bioavailability of haloperidol in schizophrenic patients

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12 December 2020

Hepatic and extrahepatic disposition of propofol in patients undergoing coronary bypass surgery

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12 December 2020

Continuous droperidol infusion for management of agitated delirium in an intensive care unit.

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12 December 2020

Intraoperative awareness during high-dose fentanyl--oxygen anesthesia.

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12 December 2020

Transdermal and transmucosal administration of pain-relieving and anxiolytic drugs: a primer for the critical care practitioner

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12 December 2020

Sedation with intravenous infusions of propofol or thiopentone. Effects on pain perception.

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12 December 2020

Pharmacokinetics of propofol and haemodynamic changes during induction of anaesthesia in uraemic patients

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12 December 2020

1 reference

12 December 2020

Pharmacokinetics of propofol during and after long-term continuous infusion for maintenance of sedation in ICU patients

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12 December 2020

High-dose naloxone: pharmacokinetics in patients in septic shock

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12 December 2020

Phenytoin-Induced Methadone Withdrawal

1 reference

12 December 2020

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo.

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12 December 2020

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

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12 December 2020

Continuous intravenous infusion of methadone for control of burn pain

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12 December 2020

Endogenous opiates: 1993.

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12 December 2020

Optimal sedation of mechanically ventilated pediatric critical care patients.

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12 December 2020

Comparison between high-dose sufentanil-oxygen and high-dose fentanyl-oxygen for neuroanaesthesia

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12 December 2020

Continuous infusion of haloperidol controls agitation in critically ill patients

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12 December 2020

Tolerance to dobutamine after a 72 hour continuous infusion

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12 December 2020

A dosing nomogram for continuous infusion intravenous naloxone.

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12 December 2020

Some pain threshold studies with particular reference to thiopentone.

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12 December 2020

Ketamine: an update on the first twenty-five years of clinical experience

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12 December 2020

Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam.

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12 December 2020

Nalmefene--a long-acting injectable opioid antagonist

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12 December 2020

Drug therapy. Current status of benzodiazepines

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12 December 2020

Prolonged sedation due to accumulation of conjugated metabolites of midazolam

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12 December 2020

Clinical studies of induction agents. XXXVII. Amnesic action of ketamine

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12 December 2020

Analgesia with subhypnotic doses of thiopentone and propofol.

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12 December 2020

[Effects of in vivo pretreatment with various barbiturates on lidocaine metabolism in rat liver microsomes]

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12 December 2020

Haloperidol as an adjunct analgesic in the management of postoperative pain.

1 reference

12 December 2020

Propofol versus midazolam. Long-term sedation in the intensive care unit

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12 December 2020

Propofol as Used for Sedation in the ICU

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12 December 2020

Pharmacokinetics of midazolam and alpha-hydroxy-midazolam following rectal and intravenous administration

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12 December 2020

Ketamine infusion. Its use as a sedative, inotrope and bronchodilator in a critically ill patient.

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12 December 2020

Continuous intravenous infusions of lorazepam versus midazolam for sedation during mechanical ventilatory support: a prospective, randomized study.

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12 December 2020

Ketamine kinetics in unmedicated and diazepam-premedicated subjects.

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12 December 2020

Importance of unbound phenytoin serum levels in head trauma patients

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12 December 2020

Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain

1 reference

12 December 2020

Effect of bolus doses of midazolam on intracranial pressure and cerebral perfusion pressure in patients with severe head injury.

1 reference

12 December 2020

Prolonged Q-T interval and hypokalemia caused by haloperidol

1 reference

12 December 2020

Pharmacokinetics and EEG effects of flumazenil in volunteers.

1 reference

12 December 2020

The amnesic action of benzodiazepines in man.

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12 December 2020

High and very high dosage antipsychotics: a critical review

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12 December 2020

What objective measures are there for evaluating pain?

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12 December 2020

The medical approach to management of pain caused by cancer

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12 December 2020

Droperidol versus haloperidol for chemical restraint of agitated and combative patients

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12 December 2020

Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine

1 reference

12 December 2020

Clinical pharmacokinetics of methadone

1 reference

12 December 2020

Kinetics of high-dose i.v. diazepam.

1 reference

12 December 2020

Impaired memory and behavioral performance with fentanyl at low plasma concentrations.

1 reference

12 December 2020

Pharmacokinetics of high-dose pentobarbital in severe head trauma.

1 reference

12 December 2020

Pharmacokinetics and analgesic effect of ketamine in man.

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12 December 2020

Pharmacokinetics of midazolam in patients recovering from cardiac surgery.

1 reference

12 December 2020

Metabolic responses of the critically ill patient.

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12 December 2020

Enhanced bioavailability of pethidine and pentazocine in patients with cirrhosis of the liver

1 reference

12 December 2020

Propofol versus midazolam for intensive care unit sedation after coronary artery bypass grafting

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12 December 2020

Dose of midazolam should be reduced during diltiazem and verapamil treatments

1 reference

12 December 2020

Inhibition of Adrenal Steroidogenesis by the Anesthetic Etomidate

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12 December 2020

Aging increases pharmacodynamic sensitivity to the hypnotic effects of midazolam.

1 reference

12 December 2020

Analgesic efficacy of low-dose ketamine. Somatosensory-evoked responses in relation to subjective pain ratings

1 reference

12 December 2020

Postoperative analgesia with fentanyl: pharmacokinetics and pharmacodynamics of constant-rate i.v. and transdermal delivery

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12 December 2020

Pharmacologic considerations in critical care of the elderly

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12 December 2020

Effective therapeutic infusions produced by closed-loop feedback control of methohexital administration during total intravenous anesthesia with fentanyl

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12 December 2020

Experiences with continuous infusions of etomidate in cardiac surgery (author's transl)

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12 December 2020

Intravenous lorazepam as an amnestic and anxiolytic agent in the intensive care unit: a prospective study.

1 reference

12 December 2020

Hydromorphone metabolite accumulation in renal failure

1 reference

12 December 2020

Dose effects of alfentanil in human analgesia

1 reference

12 December 2020

Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam.

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12 December 2020

Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions

1 reference

12 December 2020

Opiate structure and activity--a guide to understanding the receptor

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12 December 2020

Effects of haloperidol on recall and information processing in verbal and spatial learning

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12 December 2020

Cimetidine alters pethidine disposition in man.

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12 December 2020

Prolonged sedation of critically ill patients with midazolam or propofol: impact on weaning and costs.

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12 December 2020

Comparative pharmacology of the ketamine isomers. Studies in volunteers

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12 December 2020

Effect of neurotrauma on hepatic drug clearance

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12 December 2020

Comparison of sedative recovery time after midazolam versus diazepam administration.

1 reference

12 December 2020

Reversal of central benzodiazepine effects by flumazenil after conscious sedation produced by intravenous diazepam. The Flumazenil in Intravenous Conscious Sedation with Diazepam Multicenter Study Group I

1 reference

12 December 2020

Awareness and recall with high-dose fentanyl-oxygen anesthesia.

1 reference

12 December 2020

Cardiovascular Response to Large Doses of Intravenous Morphine in Man

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12 December 2020

Kinetics of drug action in disease states. XXV. Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam.

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12 December 2020

Effect of renal impairment and hemodialysis on lorazepam kinetics

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12 December 2020

Droperidol causes a dose-dependent prolongation of the QT interval

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12 December 2020

Acute tolerance to high-dose barbiturate treatment in patients with severe head injuries.

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12 December 2020

Is alfentanil by infusion useful for sedation on the ITU?

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12 December 2020

Age and nature of operation influence the pharmacokinetics of midazolam.

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12 December 2020

Prolonged antagonism of opioid action with intravenous nalmefene in man.

1 reference

12 December 2020

High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury

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12 December 2020

The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers

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12 December 2020

Sedation in intensive care: morphine and renal function

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12 December 2020

Narcotic “Anesthesia” in the Eighties

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12 December 2020

Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer

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12 December 2020

Rifampin-Induced Methadone Withdrawal

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12 December 2020

Studies in fentanyl-supplemented anaesthesia: awareness and effect of naloxone on early post-operative recovery.

1 reference

12 December 2020

Morphine pharmacokinetics during anesthesia and surgery in patients with burns.

1 reference

12 December 2020

Pharmacokinetics of propofol (diprivan) in elderly patients

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12 December 2020

Midazolam infusion for basal sedation in intensive care: absence of accumulation.

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12 December 2020

Antipyrine elimination in critically ill patients

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12 December 2020

Dopamine-phenytoin interaction. A cause of hypotension in the critically ill

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12 December 2020

Effects of delta-9-tetrahydrocannabinol on drug distribution and metabolism. Antipyrine, pentobarbital, and ethanol

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12 December 2020

The effect of pentazocine on pupillary size and intracranial pressure

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12 December 2020

[Continuous Midazolam infusion for sedation of respirator patients]

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12 December 2020

The use of computers for controlling the delivery of anesthesia

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12 December 2020

Infusion of propofol versus midazolam for sedation in the intensive care unit following coronary artery surgery.

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12 December 2020

Diazepam kinetics in patients with severe burns.

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12 December 2020

A pharmacological and theoretical comparison of high and low potency neuroleptics

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12 December 2020

Acute trauma alters morphine clearance

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12 December 2020

Correlation between plasma diphenhydramine level and sedative and antihistamine effects

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12 December 2020

Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.

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12 December 2020

The effect of cirrhosis on the disposition and elimination of meperidine in man

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12 December 2020

The interactions of midazolam and flumazenil on human memory and cognition.

1 reference

12 December 2020

Thiopental pharmacokinetics under conditions of long-term infusion

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12 December 2020

The pharmacokinetics and pharmacodynamics of remifentanil in volunteers with severe hepatic or renal dysfunction.

1 reference

12 December 2020

Bioavailability of fluconazole in surgical intensive care unit patients: a study comparing routes of administration

1 reference

12 December 2020

Droperidol vs. haloperidol in the initial management of acutely agitated patients.

1 reference

12 December 2020

Pharmacodynamics and Pharmacokinetics of Methadone during the Perioperative Period

1 reference

12 December 2020

Blood levels of neuroleptics: state of the art.

1 reference

12 December 2020

Clinical effects of parenteral narcotics in hospitalized medical patients

1 reference

12 December 2020

Effects of model traumatic injury on hepatic drug metabolism in the rat. IV. Glucuronidation

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12 December 2020

Clinical pharmacokinetics of chlordiazepoxide in patients with alcoholic hepatitis

1 reference

12 December 2020

1 reference

12 December 2020

In vivo and in vitro effect of cimetidine, inflammation, and hypoxia on propofol kinetics.

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12 December 2020

Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Society of Critical Care Medicine

1 reference

12 December 2020

Lorazepam-valproate interaction: studies in normal subjects and isolated perfused rat liver

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12 December 2020

Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (librium).

1 reference

12 December 2020

Lorazepam in intensive care

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12 December 2020

Pharmacokinetics of etomidate, a new intravenous anesthetic

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12 December 2020

Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe.

1 reference

12 December 2020

Toxic effects of drugs used in the ICU. Anticoagulants and thrombolytics. Risks and benefits

1 reference

12 December 2020

Monitoring of pentobarbital plasma levels in critical care patients suffering from increased intracranial pressure

1 reference

12 December 2020

Plasma and cerebrospinal fluid concentrations of morphine and morphine glucuronides after oral morphine. The influence of renal failure.

1 reference

12 December 2020

Pharmacology of intravenous sedatives and opioids in critically ill patients.

1 reference

12 December 2020

The influence of hepatic plasma flow on alfentanil plasma concentration plateaus achieved with an infusion model in humans: measurement of alfentanil hepatic extraction coefficient.

1 reference

12 December 2020

Pharmacokinetics of morphine sulfate in patients with burns

1 reference

12 December 2020

Profound reduction in morphine clearance and liver blood flow in shock

1 reference

12 December 2020

Drug absorption in gastrointestinal disease and surgery. Clinical pharmacokinetic and therapeutic implications

1 reference

12 December 2020

[Plasma levels following high diazepam doses in intensive-care medicine (author's transl)]

1 reference

12 December 2020

Concentration-related effects of morphine on cognition and motor control in human subjects

1 reference

12 December 2020

Pharmacokinetic implications for the clinical use of propofol

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12 December 2020

Effects of enzyme induction, renal and cardiac function on ketamine plasma kinetics in patients with ketamine long-term analgosedation.

1 reference

12 December 2020

Repeated diazepam dosing in cirrhotic patients: cumulation and sedation.

1 reference

12 December 2020

Diazepam disposition determinants.

1 reference

12 December 2020

Verapamil disposition in liver disease and intensive-care patients: kinetics, clearance, and apparent blood flow relationships

1 reference

12 December 2020

Duration of amnesia during sedation with diazepam and pentazocine: preliminary report

1 reference

12 December 2020

Use of midazolam infusion for sedation following cardiac surgery.

1 reference

12 December 2020

Subanesthetic concentrations of desflurane and propofol suppress recall of emotionally charged information

1 reference

12 December 2020

Pharmacokinetics of etomidate associated with prolonged i.v. infusion

1 reference

12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

12 December 2020

Clinical pharmacokinetics of long-term infusion of midazolam in critically ill patients--preliminary results.

1 reference

12 December 2020

Lorazepam conjugation is unimpaired in burn trauma

1 reference

12 December 2020

Pharmacokinetics of diazepam and midazolam when used for sedation following cardiopulmonary bypass.

1 reference

12 December 2020

A prospective evaluation of benzodiazepine guidelines in the management of patients hospitalized for alcohol withdrawal

1 reference

12 December 2020

A placebo-controlled trial of flumazenil given by continuous infusion in severe benzodiazepine overdosage

1 reference

12 December 2020

Managing agitation in critically ill patients.

1 reference

12 December 2020

Alfentanil infusions on the intensive therapy unit.

1 reference

12 December 2020

Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill.

1 reference

12 December 2020

Effects of antipsychotic drugs on memory functions of schizophrenic patients

1 reference

12 December 2020

Modifications of the classic neuroleptanalgesic technique

1 reference

12 December 2020

Reversal of central nervous system effects by flumazenil after intravenous conscious sedation with midazolam: report of a multicenter clinical study. The Flumazenil in Intravenous Conscious Sedation with Midazolam Multicenter Study Group I

1 reference

12 December 2020

Lack of effect of flumazenil on the reversal of propofol anaesthesia

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12 December 2020

Differential amnestic properties of short- and long-acting benzodiazepines

1 reference

12 December 2020

Effects of eight-hour naloxone infusions on human subjects.

1 reference

12 December 2020

Intravenous premedication with diazepam. A comparison between two vehicles.

1 reference

12 December 2020

The effect of midazolam and lorazepam on postoperative recovery after cardiac surgery.

1 reference

12 December 2020

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

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12 December 2020

Relationship between morphine and etonitazene-induced working memory impairment and analgesia.

1 reference

12 December 2020

Is chlordiazepoxide the rational choice among benzodiazepines?

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12 December 2020

Critical care medicine in managed competition and a managed care environment

1 reference

12 December 2020

Alfentanil increases intracranial pressure when intracranial compliance is low

1 reference

12 December 2020

Use of a fentanyl infusion in the intensive care unit: tolerance to its anesthetic effects?

1 reference

12 December 2020

Flumazenil disposition and elimination in cirrhosis

1 reference

12 December 2020

Treatment modalities for hypertensive patients with intracranial pathology: options and risks

1 reference

12 December 2020

Hyperalgesia during sedation: effects of barbiturates and propofol in the rat.

1 reference

12 December 2020

Postoperative myoclonus and rigidity after anesthesia with opioids

1 reference

12 December 2020

Biodisposition of ketamine in the rat: self-induction of metabolism

1 reference

12 December 2020

Intensive management of severe head injury

1 reference

12 December 2020

Pharmacokinetics of alfentanil in chronic renal failure.

1 reference

12 December 2020

Pharmacokinetics of midazolam in anaesthetized cirrhotic patients.

1 reference

12 December 2020

Hydromorphone levels and pain control in patients with severe chronic pain.

1 reference

12 December 2020

Prolonged midazolam elimination half-life

1 reference

12 December 2020

Effect of omeprazole and cimetidine on plasma diazepam levels.

1 reference

12 December 2020

Pharmacokinetics of an infusion of propofol during cardiac surgery

1 reference

12 December 2020

Ventricular irritability associated with the use of naloxone hydrochloride. Two case reports and laboratory assessment of the effect of the drug on cardiac excitability.

1 reference

12 December 2020

Intravenous fentanyl kinetics.

1 reference

12 December 2020

Naloxone fails to affect short-term memory in man

1 reference

12 December 2020

The effect of increasing age on thiopental disposition and anesthetic requirement

1 reference

12 December 2020

Cimetidine impairs elimination of chlordiazepoxide (Librium) in man

1 reference

12 December 2020

Relationship between blood meperidine concentrations and analgesic response: a preliminary report.

1 reference

12 December 2020

The nonhypnotic therapeutic applications of propofol.

1 reference

12 December 2020

Chlordiazepoxide metabolite accumulation in liver disease

1 reference

12 December 2020

Relationship of plasma levels of chlordiazepoxide and metabolites to clinical response

1 reference

12 December 2020

Pharmacokinetics of naloxone in rats and in man: basis for its potency and short duration of action

1 reference

12 December 2020

Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol

1 reference

12 December 2020

Respiratory effects of hydromorphone in man

1 reference

12 December 2020

The influence of renal failure on the kinetics of intravenous midazolam: an "in vitro" and "in vivo" study

1 reference

12 December 2020

The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

1 reference

12 December 2020

Failure of critically ill patients to metabolise midazolam.

1 reference

12 December 2020

Effect of model traumatic injury on hepatic drug-metabolizing enzymes

1 reference

12 December 2020

Therapy of alcohol withdrawal syndrome in intensive care unit patients following trauma: results of a prospective, randomized trial

1 reference

12 December 2020

MULTI-FORTE, a microcomputer program for modelling and simulation of pharmacokinetic data

1 reference

12 December 2020

[The use of ketamine and midazolam for analgesia and sedation in ventilated patients subject to obligatory treatment with catecholamines]

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic considerations in drug therapy of cardiac emergencies

1 reference

12 December 2020

Alfentanil kinetics in renal insufficiency.

1 reference

12 December 2020

Pharmacokinetics and clinical experience of 20-h infusions of methohexitone in intensive care patients with postoperative pyrexia

1 reference

12 December 2020

Lorazepam as a sedative-amnesic in an intensive Care unit

1 reference

12 December 2020

Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood

1 reference

12 December 2020

The Mechanism of Increased Intracranial Pressure Induced by Morphine

1 reference

12 December 2020

Decreased plasma albumin concentration results in increased volume of distribution and decreased elimination of midazolam in intensive care patients.

1 reference

12 December 2020

Hepatic blood flow and splanchnic oxygen consumption measurements in clinical sepsis.

1 reference

12 December 2020

Opiates, mast cells and histamine release

1 reference

12 December 2020

Absolute bioavailability of pirenzepine in intensive care patients

1 reference

12 December 2020

[Pharmacokinetics of midazolam in patients with liver damage for hepatectomy]

1 reference

12 December 2020

The pharmacokinetics of meperidine in acute trauma patients

1 reference

12 December 2020

Awareness and recall during general anesthesia. Facts and feelings.

1 reference

12 December 2020

Pharmacoeconomic impact of critically ill surgical patients

1 reference

12 December 2020

Concentration-effect relationships of propofol after total intravenous anesthesia.

1 reference

12 December 2020

Comparison of potency and duration of action of nalmefene and naloxone.

1 reference

12 December 2020

Clinical Pharmacokinetics of Chlordiazepoxide

1 reference

12 December 2020

Pharmacokinetics and analgesic effects of i.m. and oral ketamine

1 reference

12 December 2020

Advantages and disadvantages of combining sedative agents.

1 reference

12 December 2020

Pentobarbital pharmacokinetics in patients with severe head injury

1 reference

12 December 2020

Methadone disposition in patients with chronic liver disease

1 reference

12 December 2020

Studies with stable isotopes II: Phenobarbital pharmacokinetics during monotherapy

1 reference

12 December 2020

Hepatic perfusion and splanchnic oxygen consumption in patients postinjury

1 reference

12 December 2020

Clinical pharmacokinetics of midazolam in intensive care patients, a wide interpatient variability?

1 reference

12 December 2020

The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.

1 reference

12 December 2020

Bioavailability of fluconazole administered via a feeding tube in intensive care unit patients

1 reference

12 December 2020

Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery.

1 reference

12 December 2020

Effect of induction of anaesthesia with etomidate on corticosteroid synthesis in man.

1 reference

12 December 2020

Alfentanil pharmacokinetics in patients with cirrhosis.

1 reference

12 December 2020

Acute high-dose parenteral haloperidol treatment of psychosis

1 reference

12 December 2020

Flumazenil reversal of midazolam sedation in the elderly.

1 reference

12 December 2020

Plasma protein binding of diazepam and tolbutamide in chronic alcoholics.

1 reference

12 December 2020

Interaction of Cimetidine with Oxazepam, Lorazepam, and Flurazepam

1 reference

12 December 2020

Head injury and cytochrome P-450 enzymes. Differential effect on mRNA and protein expression in the Fischer-344 rat.

1 reference

12 December 2020

10.2165/00003088-199733060-00003

Identifiers

DOI

1 reference

Dimensions Publication ID

24 September 2017

1026020690

0 references

1 reference