(Q40896821)

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Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives

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scholarly article

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Europe PubMed Central

24 September 2017

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Europe PubMed Central

Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives (English)

1 reference

Europe PubMed Central

24 September 2017

Alzheimer's disease

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cognitive dysfunction

1 reference

based on heuristic

inferred from title

author name string

Francis PT

1

1 reference

Europe PubMed Central

24 September 2017

Sims NR

2

1 reference

Europe PubMed Central

24 September 2017

Procter AW

3

1 reference

Europe PubMed Central

24 September 2017

Bowen DM

4

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Europe PubMed Central

24 September 2017

language of work or name

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publication date

1 May 1993

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Europe PubMed Central

24 September 2017

Journal of Neurochemistry

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Europe PubMed Central

24 September 2017

60

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Europe PubMed Central

24 September 2017

1589-1604

1 reference

Europe PubMed Central

24 September 2017

5

1 reference

Europe PubMed Central

24 September 2017

Learning and memory

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Immunocytochemical localization of glutaminase-like and aspartate aminotransferase-like immunoreactivities in the rat and guinea pig hippocampus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Huntington's chorea: post mortem activity of enzymes involved in cerebral glucose metabolism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Neuropathological stageing of Alzheimer-related changes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

8-Hydroxy-2-(di-n-propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5-HT1A receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

d-Cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-d-aspartate receptor-ionophore complex in Alzheimer brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Excitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Intramuscular desferrioxamine in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

The association of [3H]D-aspartate binding and high-affinity glutamate uptake in the human brain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Clinical history, brain metabolism, and neuropsychological function in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Two distinct effects of 5-hydroxytryptamine on single cortical neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Heterogeneity of sodium-dependent excitatory amino acid uptake mechanisms in rat brain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Glutamate: A Neurotransmitter in Mammalian Brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Animal and drug modelling for Alzheimer synaptic pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Measuring the neuromodulatory effects of drugs in man with positron emission tomography

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Kynurenate inhibition of cell excitation decreases stroke size and deficits

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Excitatory amino acids and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Sodium-dependent D-aspartate 'binding' is not a measure of presynaptic neuronal uptake sites in an autoradiographic assay.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico-Striatal Transmitter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Pharmacology of the corticocaudate excitatory postsynaptic potential in the cat: evidence for its mediation by quisqualate- or kainate-receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Memory-related neural systems in Alzheimer's disease: an anatomic study.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Glutamic acid as a synaptic transmitter candidate in the dorsal sensory neuron: Reconsiderations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Immunohistochemical study of glutaminase-containing neurons in the cerebral cortex and thalamus of the rat.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Effect of frontal cortex ablation on striatal glutamic acid level in rat.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Cognitive deficits in olivopontocerebellar atrophy: implications for the cholinergic hypothesis of Alzheimer's dementia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Selective retrograde labeling with D-[3H]-aspartate in afferents to the mammalian superior colliculus.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Convergence and divergence of neurotransmitter action in human cerebral cortex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Serotonin, memory, and the aging brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Abnormal temporal lobe response in Alzheimer's disease during cognitive processing as measured by 11C-2-deoxy-D-glucose and PET.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Somatostatin replacement therapy for alzheimer dementia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Biochemical measurements in Alzheimer's disease reveal a necessity for improved neuroimaging techniques to study metabolism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Catecholaminergic neurones assessed ante-mortem in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Possible neurotransmitter basis of behavioral changes in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Destruction of a sub-population of cortical neurones by suicide transport of volkensin, a lectin from Adenia volkensii

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

NMDA receptors assessed by autoradiography with [3H]L-689,560 are present but not enriched on corticofugal-projecting pyramidal neurones

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Glutamic acid as a putative transmitter of the interhemispheric corticocortical connections in the rat.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of Meynert in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Topographical distribution of neurochemical changes in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Norepinephrine and MHPG levels in CSF and plasma in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Regional cerebral blood flow measurements by 133Xe-inhalation: methodology and applications in neuropsychology and psychiatry.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

The influence of neuronal 5-hydroxytryptamine receptor antagonists on non-cholinergic ganglionic transmission in the guinea-pig enteric excitatory reflex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Failure of d-cycloserine to reverse cognitive disruption induced by scopolamine or phencyclidine in primates

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Glycine prodrug facilitates memory retrieval in humans

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Presynaptic cholinergic dysfunction in patients with dementia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Metabolic processes in Alzheimer's disease: adenine nucleotide content and production of 14CO2 from [U-14C]glucose in vitro in human neocortex.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Mitochondrial function in brain tissue in primary degenerative dementia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

The evoked release of endogenous amino acids from tissue prisms of human neocortex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Monoaminergic and cholinergic synaptic markers in the nucleus basalis of Meynert (nbM): normal age-related changes and the effect of heart disease and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Selective vulnerability of neurones in organic dementia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Modeccin and volkensin but not abrin are effective suicide transport agents in rat CNS.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Excitatory amino acid neurotransmitters in the corticostriate pathway: studies using intracerebral microdialysis in vivo.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.1993.TB13381.X

21 January 2018

Identifiers

10.1111/J.1471-4159.1993.TB13381.X

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

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