(Q40906099)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

0 references

5

1 reference

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3 November 2019

author name string

J N Octave

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

R Essalmani

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

B Tasiaux

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

J Menager

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

L Mercken

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

English

0 references

publication date

1 January 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

3 November 2019

published in

1 reference

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3 November 2019

volume

275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

1525-1528

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636839%20AND%20SRC:MED&resulttype=core&format=json

The Alzheimer family of diseases: many etiologies, one pathogenesis?

3 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Immunolocalization of Alzheimer ?-amyloid peptide precursor to cellular membranes in baculovirus expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Baculovirus-infected cells do not produce the amyloid peptide of Alzheimer's disease from its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Alzheimer's disease. In search of gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525

Subcellular distribution and turnover of presenilins in transfected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.3.1525