(Q40915870)

English

Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites

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scholarly article

1 reference

Europe PubMed Central

24 September 2017

Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites (English)

1 reference

Europe PubMed Central

24 September 2017

0 references

protein ubiquitination

1 reference

based on heuristic

inferred from title

immunosuppression

1 reference

based on heuristic

inferred from title

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Y Zhang

1

1 reference

Europe PubMed Central

24 September 2017

X Sun

2

1 reference

Europe PubMed Central

24 September 2017

K Muraoka

3

1 reference

Europe PubMed Central

24 September 2017

A Ikeda

4

1 reference

Europe PubMed Central

24 September 2017

S Miyamoto

5

1 reference

Europe PubMed Central

24 September 2017

H Shimizu

6

1 reference

Europe PubMed Central

24 September 2017

K Yoshioka

7

1 reference

Europe PubMed Central

24 September 2017

K Yamamoto

8

1 reference

Europe PubMed Central

24 September 2017

language of work or name

0 references

publication date

1 December 1999

1 reference

Europe PubMed Central

24 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

24 September 2017

274

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Europe PubMed Central

24 September 2017

49

1 reference

Europe PubMed Central

24 September 2017

34657-34662

1 reference

Europe PubMed Central

24 September 2017

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Signal transduction through NF-kappa B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Identification and characterization of an IkappaB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

The mechanism of action of cyclosporin A and FK506

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

pEF-BOS, a powerful mammalian expression vector

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Limb and skin abnormalities in mice lacking IKKalpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Signal transduction via the MAP kinases: proceed at your own RSK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.34657

21 January 2018

Identifiers

10.1074/JBC.274.49.34657

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

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