(Q40937831)

25 September 2017

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title

Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution (English)

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25 September 2017

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Y Takakura

1

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PubMed ID

8792417

25 September 2017

M Hashida

series ordinal

2

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25 September 2017

1 June 1996

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25 September 2017

Pharmaceutical Research

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25 September 2017

13

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25 September 2017

6

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25 September 2017

820-831

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Galactosylated histone-mediated gene transfer and expression

25 September 2017

1 reference

12 December 2020

Generation of cytotoxic agents by targeted enzymes

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12 December 2020

Enhancement of tumouricidal activity of daunomycin by receptor-mediated delivery. In vivo studies

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12 December 2020

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake

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12 December 2020

Improvement of therapeutic effect of human recombinant superoxide dismutase on ischemic acute renal failure in the rat via cationization and conjugation with polyethylene glycol

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12 December 2020

Macromolecular drug carrier systems in cancer chemotherapy: macromolecular prodrugs

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12 December 2020

Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells

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12 December 2020

Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex.

1 reference

12 December 2020

Identification of a monoclonal antibody, TV-1, directed against the basement membrane of tumor vessels, and its use to enhance the delivery of macromolecules to tumors after conjugation with interleukin 2.

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12 December 2020

Tumor localization and in vivo antitumor activity of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate.

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12 December 2020

Synthesis of a superoxide dismutase derivative that circulates bound to albumin and accumulates in tissues whose pH is decreased

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12 December 2020

Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor

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12 December 2020

Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism

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12 December 2020

Hepatic disposition characteristics of electrically charged macromolecules in rat in vivo and in the perfused liver

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12 December 2020

A novel gene delivery system using EGF receptor-mediated endocytosis

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12 December 2020

Disposition characteristics of macromolecules in tumor-bearing mice

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12 December 2020

Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice

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12 December 2020

Magnetically Responsive Microspheres and Other Carriers for the Biophysical Targeting of Antitumor Agents

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12 December 2020

Disposition and tumor localization of mitomycin C-dextran conjugates in mice

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12 December 2020

Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism: effect of molecular weight of proteins on targeting efficiency

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12 December 2020

Chemotherapy through Lysosomes with a DNA-Daunorubicin Complex

1 reference

12 December 2020

Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion

1 reference

12 December 2020

2-Imino-2-methoxyethyl 1-thioglycosides: new reagents for attaching sugars to proteins

1 reference

12 December 2020

Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives

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12 December 2020

Delivery of peptides and proteins through the blood-brain barrier

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12 December 2020

Follow-up study of patients treated with monoclonal antibody-drug conjugate: report of 77 cases with colorectal cancer

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12 December 2020

Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding

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12 December 2020

Cell surface actions of adriamycin

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12 December 2020

Vascular targeting--a new approach to the therapy of solid tumors

1 reference

12 December 2020

Passive tumor targeting of soluble macromolecules and drug conjugates

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12 December 2020

Macromolecule-drug conjugates in targeted cancer chemotherapy

1 reference

12 December 2020

Disposition characteristics of recombinant human interleukin-11 after a bolus intravenous administration in mice

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12 December 2020

Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body

1 reference

12 December 2020

Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting

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12 December 2020

The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake

1 reference

12 December 2020

An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes

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12 December 2020

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

1 reference

12 December 2020

Tumoritropic and lymphotropic principles of macromolecular drugs

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12 December 2020

Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties

1 reference

12 December 2020

Incorporation of adenovirus into a ligand-based DNA carrier system results in retention of original receptor specificity and enhances targeted gene expression

1 reference

12 December 2020

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1 reference

12 December 2020

Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features

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12 December 2020

Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells

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12 December 2020

Identifiers

DOI

10.1023/A:1016084508097

1 reference

25 September 2017

1 reference

PubMed ID

8792417