(Q40939473)

25 September 2017

title

Paradoxical activation of Raf by a novel Raf inhibitor (English)

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25 September 2017

C A Hall-Jackson

1

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25 September 2017

P A Eyers

2

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25 September 2017

P Cohen

3

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25 September 2017

M Goedert

4

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25 September 2017

F T Boyle

5

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25 September 2017

N Hewitt

6

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25 September 2017

H Plant

7

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25 September 2017

P Hedge

8

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25 September 2017

publication date

1 August 1999

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25 September 2017

published in

Chemistry and Biology

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25 September 2017

volume

6

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25 September 2017

issue

8

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25 September 2017

page(s)

559-568

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

25 September 2017

cites work

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Signal transduction by receptors with tyrosine kinase activity

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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7 January 2021

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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7 January 2021

Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

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7 January 2021

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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7 January 2021

Activation of Raf as a result of recruitment to the plasma membrane

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7 January 2021

The complexity of Raf-1 regulation

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7 January 2021

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

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7 January 2021

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

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7 January 2021

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

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EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

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7 January 2021

Hyperexpression of mitogen-activated protein kinase in human breast cancer

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7 January 2021

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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7 January 2021

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

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7 January 2021

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

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7 January 2021

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.

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7 January 2021

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

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7 January 2021

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

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7 January 2021

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

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7 January 2021

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

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7 January 2021

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

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7 January 2021

KSR: a novel player in the RAS pathway

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7 January 2021

Insulin stimulation of gene expression mediated by p21ras activation.

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7 January 2021

10.1016/S1074-5521(99)80088-X

Identifiers

DOI

1 reference

25 September 2017

1 reference