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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
scientific article published on 16 December 2004
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scholarly article
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Europe PubMed Central
PMCID
545810
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
title
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
(English)
1 reference
stated in
Europe PubMed Central
PMCID
545810
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
main subject
proteolysis
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inferred from title
author
J. Julian Blow
series ordinal
2
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Europe PubMed Central
PMCID
545810
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
author name string
Anatoliy Li
series ordinal
1
1 reference
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Europe PubMed Central
PMCID
545810
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
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6 January 2020
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English
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publication date
16 December 2004
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Europe PubMed Central
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545810
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retrieved
6 January 2020
published in
The EMBO Journal
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545810
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
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6 January 2020
volume
24
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Europe PubMed Central
PMCID
545810
reference URL
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retrieved
6 January 2020
page(s)
395-404
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Europe PubMed Central
PMCID
545810
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
issue
2
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Europe PubMed Central
PMCID
545810
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6 January 2020
cites work
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
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PubMed Central
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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint
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PubMed Central
reference URL
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25 September 2017
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis
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PubMed Central
reference URL
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25 September 2017
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication
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PubMed Central
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25 September 2017
Loss of Geminin induces rereplication in the presence of functional p53
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The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation
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Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation
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25 September 2017
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding
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PubMed Central
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Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination.
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The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
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PubMed Central
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A p53-dependent checkpoint pathway prevents rereplication
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PubMed Central
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Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest
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Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus
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Control of DNA replication licensing in a cell cycle
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Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import.
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25 September 2017
Control of DNA replication and chromosome ploidy by geminin and cyclin A
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25 September 2017
Replication licensing--defining the proliferative state?
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25 September 2017
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins
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25 September 2017
The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis
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25 September 2017
Redundant control of rereplication in fission yeast
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25 September 2017
The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
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PubMed Central
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25 September 2017
Control of chromosomal DNA replication in the early Xenopus embryo
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
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PubMed Central
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25 September 2017
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex
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25 September 2017
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
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PubMed Central
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25 September 2017
The APC is dispensable for first meiotic anaphase in Xenopus oocytes.
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25 September 2017
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
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PubMed Central
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25 September 2017
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
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PubMed Central
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25 September 2017
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
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25 September 2017
The Cdt1 protein is required to license DNA for replication in fission yeast
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25 September 2017
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
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25 September 2017
Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
Cell cycle-regulated proteolysis of mitotic target proteins
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PubMed Central
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25 September 2017
The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin
1 reference
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PubMed Central
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25 September 2017
Geminin, an inhibitor of DNA replication, is degraded during mitosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factor.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor
1 reference
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PubMed Central
reference URL
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25 September 2017
MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
A role for the nuclear envelope in controlling DNA replication within the cell cycle
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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25 September 2017
The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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17 June 2018
Characterization of the Xenopus replication licensing system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
retrieved
17 June 2018
The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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17 June 2018
Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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17 June 2018
Interaction between the origin recognition complex and the replication licensing system in Xenopus.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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17 June 2018
Determination of initiation of DNA replication before and after nuclear formation in Xenopus egg cell free extracts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
retrieved
17 June 2018
Purification of an MCM-containing complex as a component of the DNA replication licensing system.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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17 June 2018
The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
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17 June 2018
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
retrieved
19 August 2018
Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
retrieved
19 August 2018
Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
retrieved
19 August 2018
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545810
retrieved
19 August 2018
Two complexes that contain histones are required for nucleosome assembly in vitro: role of nucleoplasmin and N1 in Xenopus egg extracts
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15616577
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/SJ.EMBOJ.7600520
1 reference
stated in
Europe PubMed Central
PMCID
545810
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
PMCID
545810
1 reference
stated in
Europe PubMed Central
PMCID
545810
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
PubMed ID
15616577
1 reference
stated in
Europe PubMed Central
PMCID
545810
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15616577%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
ResearchGate publication ID
8113255
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