(Q40954991)

English

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

scientific article published on May 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

phosphorylation

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based on heuristic

inferred from title

author name string

Missbach M

1

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Jeschke M

2

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Feyen J

3

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Müller K

4

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Glatt M

5

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Green J

6

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Susa M

7

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 May 1999

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

24

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Europe PubMed Central

PubMed publication ID

25 September 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

437-449

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Substrate recognition by osteoclast precursors induces C-src/microtubule association.

1 reference

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7 January 2021

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Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

1 reference

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7 January 2021

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RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class

1 reference

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Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

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7 January 2021

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N-terminal truncation of salmon calcitonin leads to calcitonin antagonists. Structure activity relationship of N-terminally truncated salmon calcitonin fragments in vitro and in vivo

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Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

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Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone

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Trabecular bone pattern factor--a new parameter for simple quantification of bone microarchitecture

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

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Osteoclasts express high levels of pp60c-src in association with intracellular membranes

1 reference

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

1 reference

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pp60 c-src expression and activity in MG-63 osteoblastic cells modulated by PTH but not required for PTH-mediated adenylate cyclase response

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A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues

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The ovariectomized rat model of postmenopausal bone loss

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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

1 reference

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Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

1 reference

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7 January 2021

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Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src

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Purification and biochemical characterization of non-myristoylated recombinant pp60c-src kinase

1 reference

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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7 January 2021

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Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts

1 reference

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Vertebrate non-receptor protein-tyrosine kinase families

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Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss

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Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1 reference

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7 January 2021

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Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1 reference

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A microtomographic system for the nondestructive evaluation of bone architecture

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Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice

1 reference

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Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

1 reference

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Quantitation of serum amyloid P component by an enzyme-linked immunoassay

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Crystal structure of the Src family tyrosine kinase Hck

1 reference

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1 reference

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Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

1 reference

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Fluoroaluminate induces pertussis toxin-sensitive protein phosphorylation: differences in MC3T3-E1 osteoblastic and NIH3T3 fibroblastic cells

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Possible involvement of focal adhesion kinase, p125FAK, in osteoclastic bone resorption.

1 reference

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Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes

1 reference

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c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

1 reference

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Colony Stimulating Factor-1-Induced Osteoclast Spreading Depends on Substrate and Requires the Vitronectin Receptor and the c-src Proto-Oncogene

1 reference

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Cellular functions regulated by Src family kinases

1 reference

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7 January 2021

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Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.

1 reference

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7 January 2021

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Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage

1 reference

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Three-dimensional structure of the tyrosine kinase c-Src

1 reference

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1 reference

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Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo

1 reference

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Identifiers

10.1016/S8756-3282(99)00020-4

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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