(Q40955648)

25 September 2017

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title

Paclitaxel: a unique tubulin interacting anticancer agent (English)

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25 September 2017

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Vyas DM

1

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25 September 2017

Kadow JF

series ordinal

2

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25 September 2017

publication date

1 January 1995

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Progress in medicinal chemistry

25 September 2017

published in

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25 September 2017

volume

32

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25 September 2017

page(s)

289-337

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Chemotherapeutic failure: resistance or insensitivity?

25 September 2017

cites work

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7 January 2021

Biological basis for cancer treatment

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7 January 2021

Screening methods in antineoplastic drug discovery

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7 January 2021

Is the P388 murine tumor no longer adequate as a drug discovery model?

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7 January 2021

Signalling targets for anticancer drug development

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7 January 2021

New protein steals the show as 'costimulator' of T cells

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7 January 2021

A biochemical function for ras--at last

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7 January 2021

The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

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7 January 2021

Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B

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7 January 2021

Taxol: a novel investigational antimicrotubule agent

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7 January 2021

An overview of experience with TAXOL (paclitaxel) in the U.S.A.

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7 January 2021

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

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7 January 2021

Promotion of microtubule assembly in vitro by taxol

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7 January 2021

Taxol stabilizes microtubules in mouse fibroblast cells

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7 January 2021

Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins

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7 January 2021

Update on the antitumor activity of paclitaxel in clinical trials

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7 January 2021

The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents

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7 January 2021

Pharmacology and toxicology of Cremophor EL diluent

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7 January 2021

First total synthesis of taxol. 1. Functionalization of the B ring

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7 January 2021

First total synthesis of taxol. 2. Completion of the C and D rings

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7 January 2021

Total synthesis of taxol

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7 January 2021

Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Taxol and taxotere--current status and future prospects

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Taxol binds to cellular microtubules

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Demonstration of the cell cycle positions of taxol-induced "asters" and "bundles" by sequential measurements of tubulin immunofluorescence, DNA content, and autoradiographic labeling of taxol-sensitive and -resistant cells.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

The effects of cyclosporins on the cell cycle of T-lymphoid cell lines

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Taxol: an antimitotic agent with a new mechanism of action

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7 January 2021

Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Effects of antimitotic agents on tubulin-nucleotide interactions

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Absence of 7-acetyl taxol binding to unassembled brain tubulin.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Direct photoaffinity labeling of tubulin with taxol

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Characterization of two taxol photoaffinity analogues bearing azide and benzophenone-related photoreactive substituents in the A-ring side chain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules

1 reference

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7 January 2021

Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogs with Increased Activities

1 reference

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7 January 2021

Modified taxols, 9. Synthesis and biological evaluation of 7-substituted photoaffinity analogues of taxol

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7 January 2021

Cell biological mechanisms of multidrug resistance in tumors

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7 January 2021

Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446

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7 January 2021

The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance

1 reference

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7 January 2021

Paclitaxel-induced cytotoxicity--the effects of cremophor EL (castor oil) on two human breast cancer cell lines with acquired multidrug resistant phenotype and induced expression of the permeability glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype

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7 January 2021

Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines

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7 January 2021

Resistance to antimitotic agents as genetic probes of microtubule structure and function

1 reference

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7 January 2021

Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

A mechanism of cellular resistance to drugs that interfere with microtubule assembly

1 reference

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7 January 2021

Taxol-requiring mutant of Chinese hamster ovary cells with impaired mitotic spindle assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Isolation of Chinese hamster ovary cell mutants requiring the continuous presence of taxol for cell division

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Pharmacology and pharmacokinetics of paclitaxel

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Phase I trial of 3-hour infusion of paclitaxel with or without granulocyte colony-stimulating factor in patients with advanced cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Isolation, structural determination, and biological activity of 6 alpha-hydroxytaxol, the principal human metabolite of taxol

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Steady-state plasma concentrations and effects of taxol for a 250 mg/m2 dose in combination with granulocyte-colony stimulating factor in patients with ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Sequences of taxol and cisplatin: a phase I and pharmacologic study

1 reference

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7 January 2021

Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Synthesis of biologically active taxol analogues with modified phenylisoserine side chains

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

19-Hydroxybaccatin III, 10-Deacetylcephalomannine, and 10-Deacetyltaxol: New Antitumor Taxanes From Taxus wallichiana

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Relationships between the structure of taxol analogs and their antimitotic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Comparison of paclitaxel and docetaxel activity on human ovarian carcinoma xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Antitumor activity of taxotere (RP 56976, NSC 628503), a new taxol analog, in experimental ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

The taxoids: paclitaxel (Taxol) and docetaxel (Taxotere).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

New bioactive taxoids from cell cultures of Taxus baccata

1 reference

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7 January 2021

New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method

1 reference

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7 January 2021

New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

On the stereochemistry of fecapentaene-12.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Preparation and biological activity of taxol acetates

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

NMR and molecular modeling study of the conformations of taxol and of its side chain methylester in aqueous and non-aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

NMR and molecular modeling study of active and inactive taxol analogues in aqueous and nonaqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Synthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and Taxotere

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Interaction of 7-acetyltaxol with different tubulin assemblies

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

New taxanes from Taxus brevifolia, 2

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

The chemistry of taxol

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

14β-Hydroxy-10-deacetylbaccatin III, a new taxane from Himalayan yew (Taxus wallichiana Zucc.)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Structure-activity relationships of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

New natural products in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Histamine release in dogs by Cremophor El® and its derivatives: Oxethylated oleic acid is the most effective constituent

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity

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7 January 2021

Design, synthesis and biological activity of protaxols

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

The human alkaline phosphatases: what we know and what we don't know

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Pharmacokinetics of the antitumor antibiotic n-pentyl-sparsomycin in beagle dogs.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Enzyme activated anti-tumour agents— II. The role of alkaline phosphatase in the release of p-hydroxyaniline mustard from its phosphate conjugate in cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Phosphoryloxymethyl carbamates and carbonates--novel water-soluble prodrugs for amines and hindered alcohols

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Phase II study of taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group Results

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Taxol in ovarian cancer.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Patient care issues: the management of paclitaxel-related toxicities

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Paclitaxel: what schedule? What dose?

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970456-9

7 January 2021

Chemistry and Biology of Taxol

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7 January 2021

10.1016/S0079-6468(08)70456-9

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DOI

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