(Q40959519)

25 September 2017

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title

Amyotrophic lateral sclerosis: current and future treatment strategies (English)

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amyotrophic lateral sclerosis

25 September 2017

main subject

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author name string

B W Festoff

series ordinal

1

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25 September 2017

publication date

1 January 1996

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25 September 2017

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25 September 2017

volume

51

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25 September 2017

issue

1

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25 September 2017

page(s)

28-44

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Projected neurodegenerative disease mortality in the United States, 1990-2040.

25 September 2017

cites work

1 reference

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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12 December 2020

The neurotrophin family of NGF-related neurotrophic factors

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12 December 2020

Mechanisms of excitotoxicity in neurologic diseases

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Neuromuscular junction macromolecules in the pathogenesis of amyotrophic lateral sclerosis

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12 December 2020

The influence of denervation on beta-amyloid protein precursor and alpha 1-antichymotrypsin in mouse skeletal muscle

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12 December 2020

Increased binding of 3H-L-deprenyl in spinal cords from patients with amyotrophic lateral sclerosis as demonstrated by autoradiography

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12 December 2020

Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo

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12 December 2020

Plasminogen Activators and Plasminogen Activator Inhibitors in Neural Developmenta

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12 December 2020

The natural history of amyotrophic lateral sclerosis and the use of natural history controls in therapeutic trials.

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Pathogenic mechanisms in sporadic amyotrophic lateral sclerosis.

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12 December 2020

Amyotrophic lateral sclerosis and glutamate--too much of a good thing?

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12 December 2020

Prevention of vertebrate neuronal death by the crmA gene

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12 December 2020

Synapse loss in the temporal lobe in Alzheimer's disease

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12 December 2020

The changing scene of neurotrophic factors

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12 December 2020

Tinkering with certain blood components can engender distinct functions in the nervous system.

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12 December 2020

The brain renin-angiotensin system: localization and general significance.

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12 December 2020

Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo

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12 December 2020

Insulin-like growth factor-1 receptors in human spinal cord: changes in amyotrophic lateral sclerosis

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12 December 2020

Insulin-like growth factor binding protein-1 at mouse neuromuscular synapses

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12 December 2020

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

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12 December 2020

General aspects of cytokine-release syndrome: timing and incidence of symptoms.

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12 December 2020

Apoptosis or programmed cell death?

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12 December 2020

Synapse loss in anterior horn neurons in amyotrophic lateral sclerosis

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12 December 2020

Strong immunoreactivity of alpha 1-antichymotrypsin co-localizes with beta-amyloid protein and ubiquitin in vacuolated muscle fibers of inclusion-body myositis

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12 December 2020

Pilot trial of branched-chain aminoacids in amyotrophic lateral sclerosis

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12 December 2020

A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death

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12 December 2020

Insulin-like growth factors/somatomedins: structure, secretion, biological actions and physiological role

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12 December 2020

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

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12 December 2020

Neuronal differentiation factors/cytokines and synaptic plasticity

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12 December 2020

The insulin-like growth factor signaling system and ALS neurotrophic factor treatment strategies

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12 December 2020

Molecular mechanisms of developmental neuronal death

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12 December 2020

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines.

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12 December 2020

The nerve growth factor 35 years later

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12 December 2020

Human basic fibroblast growth factor: nucleotide sequence and genomic organization

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12 December 2020

"Untreatable" neuromuscular disease. Treatment trials and symptomatic treatment of amyotrophic lateral sclerosis

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12 December 2020

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

1 reference

12 December 2020

Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction

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12 December 2020

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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12 December 2020

The natural history of amyotrophic lateral sclerosis.

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12 December 2020

Clinical trials in ALS: measurement and natural history

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12 December 2020

Receptors for the TGF-beta superfamily: multiple polypeptides and serine/threonine kinases

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12 December 2020

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

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12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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12 December 2020

World Federation of Neurology Research Group on Neuromuscular Diseases Subcommittee on Motor Neuron Disease. Airlie House guidelines. Therapeutic trials in amyotrophic lateral sclerosis. Airlie House "Therapeutic Trials in ALS" Workshop Contributors

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12 December 2020

The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

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12 December 2020

Branched-chain amino acids and ALS

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12 December 2020

Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation

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12 December 2020

Neurotrophic regulation of mouse muscle beta-amyloid protein precursor and alpha 1-antichymotrypsin as revealed by axotomy

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12 December 2020

Plasminogen activators and inhibitors in the neuromuscular system: III. The serpin protease nexin I is synthesized by muscle and localized at neuromuscular synapses

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12 December 2020

Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo

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12 December 2020

Neurotrophic factors enter the clinic.

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12 December 2020

Clinical trials in a changing era.

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12 December 2020

Recombinant growth hormone treatment of amyotrophic lateral sclerosis

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12 December 2020

Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: a hypothesis

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12 December 2020

Plasminogen activator in mammalian skeletal muscle: characteristics of effect of denervation on urokinase-like and tissue activator

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12 December 2020

A pilot trial of dextromethorphan in amyotrophic lateral sclerosis

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12 December 2020

Amyotrophic lateral sclerosis: theories and therapies

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12 December 2020

Molecular regulation of apoptosis: genetic controls on cell death.

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12 December 2020

Proteolytic activity, synapse elimination, and the Hebb synapse

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12 December 2020

Insulin-like growth factor-I: potential for treatment of motor neuronal disorders

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12 December 2020

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

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12 December 2020

Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor

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12 December 2020

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease.

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12 December 2020

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

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12 December 2020

The nerve growth factor: its mode of action on sensory and sympathetic nerve cells

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12 December 2020

Relevance of the Balance between Glia‐Derived Nexin and Thrombin following Lesion in the Nervous System

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12 December 2020

Cell death during development of the nervous system

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12 December 2020

Onset, natural history and outcome in idiopathic adult motor neuron disease

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12 December 2020

The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes

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12 December 2020

Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity

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12 December 2020

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy.

1 reference

12 December 2020

Apoptosis: the cell cycle and cell death.

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12 December 2020

IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

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12 December 2020

Genetic control of programmed cell death in the nematode C. elegans.

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12 December 2020

Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in management

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12 December 2020

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

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12 December 2020

Evidence for autoimmunity in amyotrophic lateral sclerosis

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12 December 2020

Dependence of postnatal motoneurones on their targets: review and hypothesis

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12 December 2020

Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis.

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12 December 2020

The neurotrophins and CNTF: specificity of action towards PNS and CNS neurons

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12 December 2020

History of the discovery of neuronal death in embryos.

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12 December 2020

Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

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12 December 2020

Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35.

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12 December 2020

Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival

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12 December 2020

Effects of ciliary neuronotrophic factor on rat spinal cord neurons in vitro: survival and expression of choline acetyltransferase and low-affinity nerve growth factor receptors

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12 December 2020

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

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12 December 2020

Regulation of protease nexin-1 expression in cultured Schwann cells is mediated by angiotensin II receptors.

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12 December 2020

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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12 December 2020

Abnormal glutamate metabolism in amyotrophic lateral sclerosis.

1 reference

12 December 2020

Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)

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12 December 2020

Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy

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12 December 2020

ICE-like proteases in apoptosis

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12 December 2020

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

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12 December 2020

GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle

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12 December 2020

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12 December 2020

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

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12 December 2020

Design of clinical therapeutic trials in amyotrophic lateral sclerosis

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12 December 2020

Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease

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12 December 2020

Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine.

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12 December 2020

Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group

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12 December 2020

A rating scale for amyotrophic lateral sclerosis: description and preliminary experience

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12 December 2020

Insulin-like growth factor binding protein-1 is pre-synaptic at mouse neuromuscular synapses and is transported in nerve

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12 December 2020

Prevention of activity-dependent neuronal death: vasoactive intestinal polypeptide stimulates astrocytes to secrete the thrombin-inhibiting neurotrophic serpin, protease nexin I

1 reference

12 December 2020

Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).

1 reference

12 December 2020

10.2165/00003495-199651010-00004

Identifiers

DOI

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Dimensions Publication ID

25 September 2017

1044794344

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