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Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA.
scientific article published on 7 July 2017
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scholarly article
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Europe PubMed Central
PMCID
5501794
retrieved
25 September 2017
title
Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA.
(English)
1 reference
stated in
Europe PubMed Central
PMCID
5501794
retrieved
25 September 2017
author
Alex N. Zelensky
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
Marcel Tijsterman
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5
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Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
author name string
Joost Schimmel
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2
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Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
Hanneke Kool
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3
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Europe PubMed Central
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5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
Roland Kanaar
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4
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Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
language of work or name
English
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publication date
7 July 2017
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Europe PubMed Central
PMCID
5501794
retrieved
25 September 2017
published in
Nature Communications
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Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
volume
8
1 reference
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Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
issue
1
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Europe PubMed Central
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5501794
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
page(s)
66
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Europe PubMed Central
PMCID
5501794
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
copyright license
Creative Commons Attribution 4.0 International
start time
7 July 2017
1 reference
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April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
exact match
https://scigraph.springernature.com/pub.10.1038/s41467-017-00124-3
0 references
cites work
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501794
retrieved
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T-DNA integration in plants results from polymerase-θ-mediated DNA repair.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501794
retrieved
25 September 2017
Genetically modified (GM) crops: milestones and new advances in crop improvement
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501794
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501794
retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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stated in
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reference URL
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retrieved
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stated in
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retrieved
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stated in
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reference URL
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retrieved
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stated in
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reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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stated in
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retrieved
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stated in
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1 reference
stated in
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1 reference
stated in
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retrieved
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1 reference
stated in
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reference URL
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retrieved
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1 reference
stated in
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reference URL
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retrieved
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1 reference
stated in
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reference URL
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stated in
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1 reference
stated in
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reference URL
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reference URL
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retrieved
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1 reference
stated in
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reference URL
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retrieved
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inferred from DOI database lookup
Mechanism of illegitimate recombination: common sites for recombination and cleavage mediated by E. coli DNA gyrase
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1038%2FS41467-017-00124-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
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reference URL
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retrieved
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based on heuristic
inferred from DOI database lookup
Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs', results in higher gene targeting efficiency
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28687761
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/S41467-017-00124-3
1 reference
stated in
Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
ADS bibcode
2017NatCo...8...66Z
0 references
Dimensions Publication ID
1090370461
0 references
PMCID
5501794
1 reference
stated in
Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
PubMed ID
28687761
1 reference
stated in
Europe PubMed Central
PMCID
5501794
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28687761%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 June 2020
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