(Q41002587)

25 September 2017

DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1. (English)

1 reference

25 September 2017

Olof J Pettersson

1

1 reference

25 September 2017

Lars Aagaard

2

1 reference

25 September 2017

Diana Andrejeva

3

1 reference

25 September 2017

Rune Thomsen

4

1 reference

25 September 2017

Thomas G Jensen

5

1 reference

25 September 2017

Christian K Damgaard

6

1 reference

25 September 2017

3 May 2014

1 reference

25 September 2017

15

1 reference

inferred from page(s)

published in

Nucleic Acids Research

1 reference

25 September 2017

42

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25 September 2017

11

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25 September 2017

7186-7200

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

25 September 2017

start time

5 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4066779/fullTextXML

inferred from PubMed Central ID database lookup

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The myotonic dystrophies: molecular, clinical, and therapeutic challenges

25 September 2017

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Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p

25 September 2017

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Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins

25 September 2017

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The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing

25 September 2017

1 reference

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New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

25 September 2017

1 reference

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Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules

25 September 2017

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25 September 2017

Stress puts TIA on TOP.

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Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR.

25 September 2017

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Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.

25 September 2017

1 reference

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RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2

25 September 2017

1 reference

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Intermolecular interactions within the abundant DEAD-box protein Dhh1 regulate its activity in vivo

25 September 2017

1 reference

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RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP.

25 September 2017

1 reference

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CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1.

25 September 2017

1 reference

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Regulation of translation by stress granules and processing bodies

25 September 2017

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The myotonic dystrophies: diagnosis and management

25 September 2017

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Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.

25 September 2017

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Pathogenic mechanisms of myotonic dystrophy

25 September 2017

1 reference

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Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly

25 September 2017

1 reference

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Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features

25 September 2017

1 reference

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The control of mRNA decapping and P-body formation.

25 September 2017

1 reference

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Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation

25 September 2017

1 reference

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TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy

25 September 2017

1 reference

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25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

General translational repression by activators of mRNA decapping

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

25 September 2017

1 reference

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MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

A conserved role of a DEAD box helicase in mRNA masking

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

The CTG repeat expansion size correlates with the splicing defects observed in muscles from myotonic dystrophy type 1 patients

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066779

Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKU352

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24792155

12 December 2020

inferred from PubMed ID database lookup

Localization of trinucleotide repeat sequences in myotonic dystrophy cells using a single fluorochrome-labeled PNA probe

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24792155

12 December 2020

inferred from PubMed ID database lookup

Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24792155

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/NAR/GKU352

1 reference

25 September 2017

1 reference

25 September 2017

PubMed publication ID

24792155

1 reference