(Q41002943)

25 September 2017

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title

Advances in the molecular characterization of tryptophan hydroxylase (English)

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25 September 2017

Mockus SM

1

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PubMed ID

9770640

25 September 2017

Vrana KE

series ordinal

2

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25 September 2017

1 June 1998

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Journal of Molecular Neuroscience

25 September 2017

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25 September 2017

10

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25 September 2017

163-179

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25 September 2017

3

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https://scigraph.springernature.com/pub.10.1007/bf02761772

25 September 2017

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cites work

Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.

1 reference

12 December 2020

Characterization of chimeric pterin-dependent hydroxylases: contributions of the regulatory domains of tyrosine and phenylalanine hydroxylase to substrate specificity

1 reference

12 December 2020

Melatonin synthesis and circadian tryptophan hydroxylase activity in chicken retina following destruction of serotonin immunoreactive amacrine and bipolar cells by kainic acid.

1 reference

12 December 2020

Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases

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12 December 2020

Tryptophan hydroxylase: cloning and expression of the rat brain enzyme in mammalian cells.

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12 December 2020

Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction

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12 December 2020

Induction of a serotonergic and neuronal phenotype in thyroid C-cells

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12 December 2020

Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism

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12 December 2020

Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element

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12 December 2020

Delineation of the catalytic core of phenylalanine hydroxylase and identification of glutamate 286 as a critical residue for pterin function

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12 December 2020

Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons

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12 December 2020

Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain

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12 December 2020

Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR)

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12 December 2020

Further studies on tryptophan hydroxylase in rat brainstem and beef pineal

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12 December 2020

A chimeric tyrosine/tryptophan hydroxylase. The tyrosine hydroxylase regulatory domain serves to stabilize enzyme activity

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12 December 2020

Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity

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12 December 2020

[Combined effect of cis-DDP (II), OK-432 and systemic hyperthermia in ascites tumor in mice]

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12 December 2020

Amino-terminal analysis of tryptophan hydroxylase: protein kinase phosphorylation occurs at serine-58

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12 December 2020

Carboxyl terminal deletion analysis of tryptophan hydroxylase

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12 December 2020

Formal demonstration of the phosphorylation of rat brain tryptophan hydroxylase by Ca2+/calmodulin-dependent protein kinase

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12 December 2020

Rapid turnover of tryptophan hydroxylase in serotonin producing cells: demonstration of ATP-dependent proteolytic degradation

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12 December 2020

Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein

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12 December 2020

Immortalization of neuroendocrine pinealocytes from transgenic mice by targeted tumorigenesis using the tryptophan hydroxylase promoter.

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12 December 2020

One sequence, two folds: a metastable structure of CD2

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12 December 2020

Multiple signal transduction mechanisms leading to the secretion of 5-hydroxytryptamine by MTC cells, a neurectodermally derived cell line

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12 December 2020

Purification and properties of tryptophan 5-monooxygenase from rat brain-stem

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12 December 2020

Molecular mechanism of the inactivation of tryptophan hydroxylase by nitric oxide: attack on critical sulfhydryls that spare the enzyme iron center.

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12 December 2020

Purification and some properties of bovine pineal tryptophan 5-monooxygenase.

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12 December 2020

In vitro experiments on the metabolism, uptake and release of 5-hydroxytryptamine in bovine retina

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12 December 2020

Distinct forms of the protein kinase-dependent activator of tyrosine and tryptophan hydroxylases

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12 December 2020

Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line

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12 December 2020

Control of tyrosine hydroxylase gene expression in chromaffin and PC12 cells.

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12 December 2020

Human medullary thyroid carcinoma: characterization of the serotonergic and neuronal properties of a neurectodermally derived cell line

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12 December 2020

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

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12 December 2020

Involvement of activator protein in the activation of tryptophan hydroxylase by cAMP-dependent protein kinase.

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12 December 2020

Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases

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12 December 2020

Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain

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12 December 2020

Synthesis and Storage of Serotonin by Parafollicular (C) Cells of the Thyroid Gland of Active, Prehibernating and Hibernating Bats

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12 December 2020

Protein splicing elements: inteins and exteins--a definition of terms and recommended nomenclature

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12 December 2020

Evidence for tryptophan hydroxylase and hydroxy-indol-O-methyl-transferase mRNAs in human blood platelets

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12 December 2020

Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase.

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12 December 2020

Inhibition of tryptophan hydroxylase by benserazide and other catechols

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12 December 2020

Associative properties of the Escherichia coli galactose-binding protein and maltose-binding protein

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12 December 2020

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization

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12 December 2020

Inactivation of tryptophan hydroxylase by nitric oxide: enhancement by tetrahydrobiopterin

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12 December 2020

Role of the N-terminus of rat pheochromocytoma tyrosine hydroxylase in the regulation of the enzyme's activity

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12 December 2020

Dopaminergic transplants alter in vivo activity of tryptophan hydroxylase in the striatum in a rat model of Parkinson's disease.

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12 December 2020

Expression and deletion mutagenesis of tryptophan hydroxylase fusion proteins: delineation of the enzyme catalytic core.

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12 December 2020

Characterization of the catalytic domain of bovine adrenal tyrosine hydroxylase

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12 December 2020

The role of the intracellular and extracellular serotonin in the regulation of melatonin production in rat pinealocytes.

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12 December 2020

Tryptophan 5-hydroxylase: approximation of half-life and rate of axonal transport.

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12 December 2020

Global suppression of protein folding defects and inclusion body formation

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12 December 2020

Tryptophan 5-hydroxylase. Rapid purification from whole rat brain and production of a specific antiserum.

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12 December 2020

Lysine241 of tyrosine hydroxylase is not required for binding of tetrahydrobiopterin substrate

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12 December 2020

Identification of the intersubunit binding region in rat tyrosine hydroxylase

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12 December 2020

Diurnal rhythm and turnover of tryptophan hydroxylase in the pineal gland of the rat

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12 December 2020

Tryptophan hydroxylase synthesis is induced by 3',5'-cyclic adenosine monophosphate during circadian rhythm in the rat pineal gland.

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12 December 2020

Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties

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12 December 2020

Mechanisms mediating biogenic amine deficits induced by amphetamine and its congeners

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12 December 2020

Tyrosine hydroxylase and tryptophan hydroxylase do not form heterotetramers

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12 December 2020

Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains

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12 December 2020

Purification, properties, and immunohistochemical localisation of human brain 14-3-3 protein.

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12 December 2020

Neurochemical basis of neurotoxicity

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12 December 2020

Regulation of tryptophan hydroxylase by cyclic AMP, calcium, norepinephrine, and light in cultured chick pineal cells

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12 December 2020

A carboxyl terminal leucine zipper is required for tyrosine hydroxylase tetramer formation

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12 December 2020

Altered serotonin metabolism in depressed patients with parkinson's disease.

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12 December 2020

Effects of nimodipine on the amphetamine- and methamphetamine-induced decrease in tryptophan hydroxylase activity

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12 December 2020

Structure and function of the aromatic amino acid hydroxylases.

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12 December 2020

In vitro reactivation of rat cortical tryptophan hydroxylase following in vivo inactivation by methylenedioxymethamphetamine

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12 December 2020

Stability Properties of Activated Tryptophan Hydroxylase from Rat Midbrain

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12 December 2020

Suicidality and 5-Hydroxyindoleacetic Acid Concentration Associated With a Tryptophan Hydroxylase Polymorphism

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12 December 2020

Site-directed mutagenesis of tyrosine hydroxylase. Role of serine 40 in catalysis

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12 December 2020

Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli

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12 December 2020

Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease

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12 December 2020

Decrease of cerebral 5-hydroxytryptamine by 3,4-dihydroxyphenylalanine after inhibition of extracerebral decarboxylase.

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12 December 2020

The relationship of serotonin to depression in Parkinson's disease

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12 December 2020

Associative properties of the Escherichia coli galactose binding protein and maltose binding protein

1 reference

12 December 2020

Inactivation of brain tryptophan hydroxylase by nitric oxide.

1 reference

12 December 2020

Serotonin-storing secretory granules from thyroid parafollicular cells

1 reference

12 December 2020

The mechanism of perturbation in monoamine metabolism by L-dopa therapy: in vivo and in vitro studies

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12 December 2020

Thyroid parafollicular cells. An accessible model for the study of serotonergic neurons.

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12 December 2020

Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites

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12 December 2020

Deletion mutants of tyrosine hydroxylase identify a region critical for heparin binding

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12 December 2020

Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons

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12 December 2020

A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila.

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12 December 2020

Characterization of recombinant mouse tryptophan hydroxylase expressed in Escherichia coli.

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12 December 2020

Tryptophan hydroxylase is phosphorylated by protein kinase A

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12 December 2020

Deletion mutagenesis of human tyrosine hydroxylase type 1 regulatory domain

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12 December 2020

Tryptophan hydroxylase. Purification and some properties of the enzyme from rabbit hindbrain

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12 December 2020

Depression in Parkinson's disease: biogenic amines in CSF of "de novo" patients

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12 December 2020

Serotonin and histamine in mast cells

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12 December 2020

Depression and Parkinson's disease: possible role of serotonergic mechanisms

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12 December 2020

Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase

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12 December 2020

Complete coding sequence of human tryptophan hydroxylase

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12 December 2020

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans

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12 December 2020

Proteolytic modification of the amino-terminal and carboxyl-terminal regions of rat hepatic phenylalanine hydroxylase

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12 December 2020

Biochemical properties of cloned glutathione S-transferases from Schistosoma mansoni and Schistosoma japonicum

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12 December 2020

Regulation of N-terminus-deleted human tyrosine hydroxylase type 1 by end products of catecholamine biosynthetic pathway

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12 December 2020

High-level expression and deletion mutagenesis of human tryptophan hydroxylase

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12 December 2020

Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+,calmodulin-dependent protein kinase II

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12 December 2020

Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.

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12 December 2020

Biochemistry of Parkinson's disease 28 years later: a critical review

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12 December 2020

Determination of some molecular parameters of tryptophan hydroxylase from rat midbrain and murine mast cell

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12 December 2020

Leucine zippers and coiled-coils in the aromatic amino acid hydroxylases

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12 December 2020

Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A.

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12 December 2020

Sequence of two mRNAs encoding active rat tryptophan hydroxylase

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12 December 2020

Further studies of the role of Ser-16 in the regulation of the activity of phenylalanine hydroxylase

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12 December 2020

Lithium and chlorimipramine differentially alter the stability properties of tryptophan hydroxylase as seen in allosteric and scattering kinetics

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12 December 2020

The abused drug MDMA (Ecstasy) induces programmed death of human serotonergic cells.

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12 December 2020

Regulation of serotonin synthesis

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12 December 2020

Partial purification of rabbit hind brain tryptophan hydroxylase by affinity chromatography

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12 December 2020

The phenylalanine hydroxylating system.

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12 December 2020

The Stimulation of Rat Liver Phenylalanine Hydroxylase by Phospholipids

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12 December 2020

Identification of Gln313 and Pro327 as residues critical for substrate inhibition in tyrosine hydroxylase

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12 December 2020

The purification of eukaryotic polypeptides synthesized in Escherichia coli

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12 December 2020

Clinical and biochemical features of depression in Parkinson's disease

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12 December 2020

Limited proteolysis of rat brain tyrosine hydroxylase defines an N-terminal region required for regulation of cofactor binding and directing substrate specificity

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12 December 2020

Glucocorticoids stimulate the production of preprocalcitonin-derived secretory peptides by a rat medullary thyroid carcinoma cell line

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12 December 2020

Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization

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12 December 2020

Tryptophan hydroxylase: purification by affinity chromatography on calmodulin-sepharose.

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12 December 2020

Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase

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12 December 2020

Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase

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12 December 2020

Deletion mutagenesis of rat PC12 tyrosine hydroxylase regulatory and catalytic domains.

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12 December 2020

Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids.

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12 December 2020

CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro

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12 December 2020

Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases

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12 December 2020

Stimulation of tryptophan hydroxylase production in a serotonin-producing cell line (RBL2H3) by intracellular calcium mobilizing reagents.

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12 December 2020

Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor.

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12 December 2020

An efficient strategy for cloning 5' extremities of rare transcripts permits isolation of multiple 5'-untranslated regions of rat tryptophan hydroxylase mRNA.

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12 December 2020

Adrenocorticotropic hormone activation of adenylate cyclase in raphe neurons: multiple regulatory pathways control serotonergic neuronal differentiation

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12 December 2020

Catalytic core of rat tyrosine hydroxylase: terminal deletion analysis of bacterially expressed enzyme.

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12 December 2020

Recombinant rabbit tryptophan hydroxylase is a substrate for cAMP-dependent protein kinase.

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12 December 2020

The enteric nervous system

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12 December 2020

Tryptophan 5-monooxygenase from mouse mastocytoma clone P815

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12 December 2020

Identifiers

DOI

10.1007/BF02761772

1 reference

PubMed ID

9770640

Dimensions Publication ID

25 September 2017

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1 reference

PubMed ID

9770640