(Q41014386)

English

Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1).

scientific article published on June 1998

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1). (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

anti-retroviral agent

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author name string

L Andrus

1

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

P Szabo

2

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

R W Grady

3

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

A R Hanauske

4

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

T Huima-Byron

5

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

B Slowinska

6

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

S Zagulska

7

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

H M Hanauske-Abel

8

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

language of work or name

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publication date

1 June 1998

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Biochemical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

55

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

1807-1818

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Is hypusine essential for eukaryotic cell proliferation?

1 reference

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7 January 2021

Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation

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A stereochemical concept for the catalytic mechanism of prolylhydroxylase: applicability to classification and design of inhibitors.

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Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate

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7 January 2021

The active site of deoxyhypusyl hydroxylase: use of catecholpeptides and their component chelator and peptide moieties as molecular probes

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Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries

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7 January 2021

The polypeptide chain of eukaryotic initiation factor 5A occurs in two distinct conformations in the absence of the hypusine modification

1 reference

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Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae

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The function of the hypusine-containing proteins of yeast and other eukaryotes is well conserved

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7 January 2021

Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication

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The dual effect of mimosine on DNA replication

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Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation

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Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes

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The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators

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A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression

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7 January 2021

1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element

1 reference

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7 January 2021

Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes

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7 January 2021

Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA

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Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs

1 reference

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7 January 2021

The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs

1 reference

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7 January 2021

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA

1 reference

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7 January 2021

Nucleocytoplasmic transport

1 reference

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7 January 2021

Intracellular expression of cellular eIF-5A mutants inhibits HIV-1 replication in human T cells: a feasibility study

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7 January 2021

Prolyl 4-hydroxylase, a target enzyme for drug development. Design of suppressive agents and the in vitro effects of inhibitors and proinhibitors

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7 January 2021

A new compound which reversibly arrests T lymphocyte cell cycle near the G1/S boundary

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7 January 2021

Mimosine reversibly arrests cell cycle progression at the G1-S phase border

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7 January 2021

A new class of reversible cell cycle inhibitors

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7 January 2021

Rev-dependency of expression of human immunodeficiency virus type 1 gag and env genes

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7 January 2021

Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A

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7 January 2021

Inhibition of human immunodeficiency virus type-1 env expression by C-5 propyne oligonucleotides specific for Rev-response element stem-loop V.

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7 January 2021

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells

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7 January 2021

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone

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Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency

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Origin of the HIV-susceptible human CD4+ cell line H9

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Failure of a human immunodeficiency virus (HIV) immune globulin to protect chimpanzees against experimental challenge with HIV

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Evidence for extensive methylation of ribosomal RNA genes in a rat XC cell line

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Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution

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Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one

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Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines

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Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells

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Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation

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Ultrastructural and confocal laser scanning microscopic examination of TUNEL-positive cells

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Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

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7 January 2021

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

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Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression

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Iron chelators induce apoptosis in proliferating cells

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A reversible arrest point in the late G1 phase of the mammalian cell cycle

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Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

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Programmed cell death: a fundamental protective response to pathogens

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Cyclosporine-induced apoptosis in CD4+ T lymphocytes and computer-simulated analysis: modeling a treatment scenario for HIV infection

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Apoptosis of HIV-infected cells following treatment with Sho-Saiko-to and its components.

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7 January 2021

The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm

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Mimosine inhibits viral DNA synthesis through ribonucleotide reductase

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7 January 2021

Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism

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Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication

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Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication

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Results of long‐term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators

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Induction of human immunodeficiency virus type 1 expression in chronically infected cells is associated primarily with a shift in RNA splicing patterns.

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Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinally studied cohort.

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Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0006-2952(98)00053-7

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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