(Q41019911)

English

Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen

scientific article published on January 1996

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scholarly article

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen (English)

1 reference

Europe PubMed Central

25 September 2017

author name string

S S Hecht

1

1 reference

Europe PubMed Central

25 September 2017

language of work or name

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publication date

1 January 1996

1 reference

Europe PubMed Central

25 September 2017

Critical Reviews in Toxicology

1 reference

Europe PubMed Central

25 September 2017

26

1 reference

Europe PubMed Central

25 September 2017

163-181

1 reference

Europe PubMed Central

25 September 2017

2

1 reference

Europe PubMed Central

25 September 2017

Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Metabolism of tobacco-specific N-nitrosamines by cultured human tissues

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

On the pharmacokinetics of tobacco-specific N-nitrosamines in Fischer rats.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Characterization of a glucuronide metabolite of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Biliary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the rat

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Glucuronidation of 4-((hydroxymethyl)nitrosamino)-1-(3-pyridyl)-1-butanone, a metabolically activated form of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, by phenobarbital-treated rats

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

1-C-glucuronidation of N-nitrosodiethylamine and N-nitrosomethyl-n-pentylamine in vivo and in primary hepatocytes from rats pretreated with inducers

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Kinetics and enzyme involvement in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in microsomes of rat lung and nasal mucosa

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Matabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human kidney epithelial cells transfected with rat CYP2B1 cDNA.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific carcinogen, by rabbit nasal microsomes and cytochrome P450s NMa and NMb

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Comparison of DNA alkali-labile sites induced by 4-(methylnitrosamino)-1(3-pyridyl)-1-butanone and 4-oxo-4-(3-pyridyl)butanal in rat hepatocytes.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Cytotoxicity, sister-chromatid exchanges and DNA single-strand breaks induced by 4-oxo-4-(3-pyridyl)butanal, a metabolite of a tobacco-specific N-nitrosamine

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

7-Methylguanine levels in DNA of smokers' and non-smokers' total white blood cells, granulocytes and lymphocytes

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Smoking-related DNA adducts: 32P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Analysis of mutagenic activity and ability to induce replication of polyoma DNA sequences by different model metabolites of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Immunocytochemical identification of DNA adducts, O6-methylguanine and 7-methylguanine, in respiratory and other tissues of rat, mouse and Syrian hamster exposed to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors.

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine

1 reference

https://api.crossref.org/works/10.3109%2F10408449609017929

21 January 2018

Identifiers

10.3109/10408449609017929

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

25 September 2017

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