(Q41036950)

25 September 2017

title

Identification of pairwise interactions in the alpha-neurotoxin-nicotinic acetylcholine receptor complex through double mutant cycles (English)

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25 September 2017

Ackermann EJ

1

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25 September 2017

Ang ET

2

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25 September 2017

Kanter JR

3

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25 September 2017

Tsigelny I

4

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25 September 2017

Taylor P

5

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25 September 2017

language of work or name

English

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publication date

1 May 1998

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Journal of Biological Chemistry

25 September 2017

published in

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25 September 2017

volume

273

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25 September 2017

issue

18

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25 September 2017

page(s)

10958-10964

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Neurotransmitter action: opening of ligand-gated ion channels

25 September 2017

cites work

1 reference

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21 January 2018

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The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor

21 January 2018

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Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

21 January 2018

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Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

21 January 2018

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Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

21 January 2018

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Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity

21 January 2018

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Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells

21 January 2018

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Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity

21 January 2018

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Anionic residue in the alpha-subunit of the nicotinic acetylcholine receptor contributing to subunit assembly and ligand binding

21 January 2018

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Projection structure of the nicotinic acetylcholine receptor: distinct conformations of the alpha subunits.

21 January 2018

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A model of the nicotinic receptor extracellular domain based on sequence identity and residue location

21 January 2018

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Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms

21 January 2018

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Tertiary structure of erabutoxin b in aqueous solution as elucidated by two-dimensional nuclear magnetic resonance

21 January 2018

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Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah)

21 January 2018

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Three dimensional structure of erabutoxin b neurotoxic protein: inhibitor of acetylcholine receptor

21 January 2018

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Nonidentity of the alpha-neurotoxin binding sites on the nicotinic acetylcholine receptor revealed by modification in alpha-neurotoxin and receptor structures

21 January 2018

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Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.

21 January 2018

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A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel.

21 January 2018

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Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

21 January 2018

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Genetic engineering of snake toxins. The functional site of Erabutoxin a, as delineated by site-directed mutagenesis, includes variant residues

21 January 2018

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Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles.

21 January 2018

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Additivity of mutational effects in proteins

21 January 2018

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Structural determinants of alpha-bungarotoxin binding to the sequence segment 181-200 of the muscle nicotinic acetylcholine receptor alpha subunit: effects of cysteine/cystine modification and species-specific amino acid substitutions

21 January 2018

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NMR solution structure of an alpha-bungarotoxin/nicotinic receptor peptide complex

21 January 2018

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Effects of mutations of Torpedo acetylcholine receptor alpha 1 subunit residues 184-200 on alpha-bungarotoxin binding in a recombinant fusion protein

21 January 2018

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The binding site of the nicotinic acetylcholine receptor in animal species resistant to alpha-bungarotoxin

21 January 2018

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Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

21 January 2018

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Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the delta subunit within 0.9 nm of the 5 alpha subunit-binding

21 January 2018

1 reference

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Ligand-receptor interactions in the nicotinic acetylcholine receptor probed using multiple substitutions at conserved tyrosines on the alpha subunit

21 January 2018

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Nicotinic acetylcholine receptor at 9 A resolution.

21 January 2018

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Structural studies of .alpha.-bungarotoxin. 1. Sequence-specific proton NMR resonance assignments

21 January 2018

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Three-dimensional crystal structure of recombinant erabutoxin a at 2.0 A resolution

21 January 2018

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Mimicry between receptors and antibodies. Identification of snake toxin determinants recognized by the acetylcholine receptor and an acetylcholine receptor-mimicking monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.10958

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.10958

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.10958

Long-range, small magnitude nonadditivity of mutational effects in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.10958

On the choice of reference mutant states in the application of the double-mutant cycle method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.10958

Interaction of protein ligands with receptor fragments. On the residues of curaremimetic toxins that recognize fragments 128-142 and 185-199 of the alpha-subunit of the nicotinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.10958

21 January 2018

Identifiers

DOI

10.1074/JBC.273.18.10958

1 reference

25 September 2017

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