(Q41039991)

English

GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease; pharmacologic profile of the benzodiazepine antagonist, flumazenil

scientific article published on July 1995

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scholarly article

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease; pharmacologic profile of the benzodiazepine antagonist, flumazenil (English)

1 reference

Europe PubMed Central

25 September 2017

author name string

Marczynski TJ

1

1 reference

Europe PubMed Central

25 September 2017

publication date

1 July 1995

1 reference

Europe PubMed Central

25 September 2017

Reviews in the Neurosciences

1 reference

Europe PubMed Central

25 September 2017

6

1 reference

Europe PubMed Central

25 September 2017

221-258

1 reference

Europe PubMed Central

25 September 2017

3

1 reference

Europe PubMed Central

25 September 2017

Specific changes in local cerebral glucose utilization in the rat brain induced by acute and chronic diazepam.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Dopamine uptake sites in Parkinson's disease and in dementia of the Alzheimer type.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Interchangeability of stress and amphetamine in sensitization

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Catecholamines and cognitive decline in aged nonhuman primates.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Effect of benzodiazepines and pentobarbital on the GABA-induced depolarization in cultured astrocytes.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Ultrastructural localization of protein kinase C beta-subspecies in the axon terminal of rat neuromuscular junction

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Alzheimer's disease. A metabolic systems degeneration?

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Alzheimer's disease: mismatch between amyloid plaques and neuritic plaques.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Functional interaction between benzodiazepine and GABA recognition sites in aged rats

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Brain Acetylcholine and Habituation

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Changes in cortical acetylcholine output induced by modulation of the nucleus basalis.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Oxidative stress, glutamate, and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The somatostatin analogue SMS 201-995 promotes paradoxical sleep in aged rats.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Neuron atrophy during aging: programmed or sporadic?

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Evidence for a tonic GABAergic control of serotonin neurons in the median raphe nucleus.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand Black mice

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The effect of diazepam sedation on cerebral glucose metabolism in Alzheimer's disease as measured using positron emission tomography.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The role of pre-synaptic GABA and benzodiazepine receptors in the control of noradrenaline release in rat hippocampus

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Age-related impairments in spatial memory are independent of those in sensorimotor skills

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Benzodiazepines: Potentiation of a GABA inhibitory response in the dorsal raphe nucleus

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Brain G-protein proteolysis by calpain: enhancement by lithium.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The effects of the benzodiazepine antagonist Ro 15-1788 on psychophysiological performance and subjective measures in normal subjects.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

GABAA receptor modulation of memory: the role of endogenous benzodiazepines

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairment

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Nerve growth factor treatment after brain injury prevents neuronal death

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Flumazenil improves active avoidance performance in aging NZB/BlNJ and C57BL/6NNia mice.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Non-motor microtubule-associated proteins.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Contributory mechanisms in the causation of neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Reserpine and the role of axonal transport in the independent regulation of pre- and postsynaptic β-adrenoreceptors

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Brain cholinergic dysfunction and memory in aged rats

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Age and sex-dependent decreases in ChAT in basal forebrain nuclei

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The Biochemistry of Memory: A New and Specific Hypothesis

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Noradrenaline- and vasoactive intestinal peptide-containing neuronal systems in neocortex: functional convergence with contrasting morphology

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Classical conditioning of the rabbit eyelid response increases glutamate receptor binding in hippocampal synaptic membranes

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Adenosine presynaptic inhibition and transmitter "spillover": a new hypothesis of etiopathogenesis of narcolepsy

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Sleep and purposive behavior: inverse deviations from randomness of neuronal firing patterns in the feline thalamus. A new form of homeostasis?

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Chronic administration of flumazenil increases life span and protects rats from age-related loss of cognitive functions: a benzodiazepine/GABAergic hypothesis of brain aging

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Animal models of chronic anxiety and "fearlessness".

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Effect of basic fibroblast growth factor on neurons cultured from various regions of postnatal rat brain.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Overlap between acetylcholinesterase-rich and choline acetyltransferase-positive (cholinergic) axons in human cerebral cortex

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Aging: effect on the interaction of ethanol and pentobarbital with the benzodiazepine-GABA receptor-ionophore complex

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Acidic fibroblast growth factor delays in vitro ischemia-induced intracellular calcium elevation in gerbil hippocampal slices: a sign of neuroprotection

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Stress induces neuronal death in the hippocampus of castrated rats.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Brain glutamate decarboxylase in Parkinson's disease with particular reference to a premortem severity index.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Chronic Ro 15–1788 treatment increases REM sleep in rats

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Programmed cell death and the control of cell survival: lessons from the nervous system

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

A cyclic GMP-stimulated cyclic nucleotide phosphodiesterase gene is highly expressed in the limbic system of the rat brain

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Cholinergic marker deficits induced by lesions of the nucleus basalis of Meynert are attenuated by nerve growth factor in young, but not in aged, F344 rats.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Potential behavioral modification of glucocorticoid damage to the hippocampus

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Acidic fibroblast growth factor prevents death of hippocampal CA1 pyramidal cells following ischemia

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Feasibility of reversing benzodiazepine tolerance with flumazenil

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Intrinsic activity of the benzodiazepine antagonist Ro 15-1788 in man: an electrophysiological investigation.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Synaptic mechanisms for long-term depression.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The molecular pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Molecular biology of dopamine receptors

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Sleep states and learning: a review of the animal literature

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Benzodiazepine-GABA receptor-ionophore complex. Current concepts

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Neuronal loss and GABAergic innervation in the basal forebrain

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Chronic exposure to flumazenil: anxiolytic effect and increased exploratory behavior.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Neurons that say NO

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Using the subcortically lesioned rat cortex to understand the physiological role of amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Intraseptal injection of GABA and benzodiazepine receptor ligands alters high-affinity choline transport in the hippocampus.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

The benzodiazepine antagonist, Ro 15-1788, increases REM and slow wave sleep in the dog.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Increased responsivity of dentate granule cells during nictitating membrane response conditioning in rabbit.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1995.6.3.221

21 January 2018

Identifiers

10.1515/REVNEURO.1995.6.3.221

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

25 September 2017

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