(Q41083547)

English

Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action

scientific article published on April 25, 1992

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 September 2017

Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1314826

12 September 2022

1 reference

10.1016/S0021-9258(18)42456-8

https://api.crossref.org/works/10.1016/S0021-9258(18)42456-8

3 December 2023

1 reference

10.1016/S0021-9258(18)42456-8

https://api.crossref.org/works/10.1016/S0021-9258(18)42456-8

3 December 2023

author name string

A. Cama

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1314826

12 September 2022

M. J. Quon

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1314826

12 September 2022

M. de la Luz Sierra

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1314826

12 September 2022

S. I. Taylor

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1314826

12 September 2022

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publication date

1 April 1992

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PubMed publication ID

26 September 2017

25 April 1992

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PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1314826

12 September 2022

full work available at URL

http://intl.jbc.org/cgi/content/abstract/267/12/8383

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1314826

12 September 2022

https://doi.org/10.1016/s0021-9258(18)42456-8

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1314826

3 December 2023

https://api.elsevier.com/content/article/PII:S0021925818424568?httpAccept=text/xml

1 reference

10.1016/S0021-9258(18)42456-8

https://api.crossref.org/works/10.1016/S0021-9258(18)42456-8

3 December 2023

https://api.elsevier.com/content/article/PII:S0021925818424568?httpAccept=text/plain

1 reference

10.1016/S0021-9258(18)42456-8

https://api.crossref.org/works/10.1016/S0021-9258(18)42456-8

3 December 2023

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

267

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

8383-8389

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Insulin Resistance, Acanthosis Nigricans, and Normal Insulin Receptors in a Young Woman: Evidence for a Postreceptor Defect

3

1 reference

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Immunological abnormalities in insulin receptors on cultured EBV-transformed lymphocytes from insulin-resistant patient with leprechaunism

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1 reference

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A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman

7

1 reference

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3 December 2023

Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone

9

1 reference

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The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

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1 reference

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Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

12

1 reference

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3 December 2023

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

13

1 reference

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3 December 2023

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity

15

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3 December 2023

The rat insulin receptor: primary structure and conservation of tissue-specific alternative messenger RNA splicing

17

1 reference

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Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.

22

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Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

25

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Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

26

1 reference

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Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance).

29

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Insulin-induced tyrosine-phosphorylation in intact rat adipocytes

32

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Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor

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Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody

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ATP sensitizes the insulin receptor to insulin

36

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After insulin binds

37

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3 December 2023

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping

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Mutations in insulin-receptor gene in insulin-resistant patients

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Differential regulation of the HepG2 and adipocyte/muscle glucose transporters in 3T3L1 adipocytes. Effect of chronic glucose deprivation

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Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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Development of the hormone-sensitive glucose transport activity in differentiating 3T3-L1 murine fibroblasts. Role of the two transporter species and their subcellular localization

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Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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1 reference

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Relationship between insulin receptor subunit association and protein kinase activation: insulin-dependent covalent and Mn/MgATP-dependent noncovalent association of alpha beta heterodimeric insulin receptors into an alpha 2 beta 2 heterotetrameric

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3 December 2023

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

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