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Loss of dysbindin-1, a risk gene for schizophrenia, leads to impaired group 1 metabotropic glutamate receptor function in mice.
scientific article published on 26 March 2015
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4374471
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859193%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
title
Loss of dysbindin-1, a risk gene for schizophrenia, leads to impaired group 1 metabotropic glutamate receptor function in mice
(English)
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4374471
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5 March 2020
main subject
schizophrenia
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Tak Pan Wong
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3
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4374471
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5 March 2020
Lalit K Srivastava
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4
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5 March 2020
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Sanjeev K Bhardwaj
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1
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4374471
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5 March 2020
Richard T Ryan
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2
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5 March 2020
publication date
26 March 2015
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5 March 2020
published in
Frontiers in Behavioral Neuroscience
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5 March 2020
volume
9
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5 March 2020
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72
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5 March 2020
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DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias
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Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti
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Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
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Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia
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Long-term depression: a cellular basis for learning?
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26 September 2017
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
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26 September 2017
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.
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26 September 2017
NMDA receptor and schizophrenia: a brief history
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Meta-analysis of genetic variation in DTNBP1 and general cognitive ability
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14 June 2018
Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses
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14 June 2018
Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice.
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14 June 2018
Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents.
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19 August 2018
Maternal care influences hippocampal N-methyl-D-aspartate receptor function and dynamic regulation by corticosterone in adulthood.
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19 August 2018
Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.
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19 August 2018
Behavioral characterization of dysbindin-1 deficient sandy mice
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19 August 2018
Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.
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19 August 2018
Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4374471
retrieved
19 August 2018
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
1 reference
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reference URL
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19 August 2018
Early environment contributes to developmental disruption of MPFC after neonatal ventral hippocampal lesions in rats
1 reference
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PubMed Central
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19 August 2018
Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: protein, mRNA splice variants, and regional distribution.
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4374471
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19 August 2018
Applications of the Morris water maze in the study of learning and memory
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFNBEH.2015.00072
retrieved
21 January 2018
Sandy: a new mouse model for platelet storage pool deficiency
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25859193
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FNBEH.2015.00072
1 reference
stated in
Europe PubMed Central
PMC publication ID
4374471
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PMC publication ID
4374471
1 reference
stated in
Europe PubMed Central
PMC publication ID
4374471
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PubMed publication ID
25859193
1 reference
stated in
Europe PubMed Central
PMC publication ID
4374471
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
ResearchGate publication ID
274722985
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