(Q41115171)

English

A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (+/-)-anti-benzo[a]pyrene-7,8-diol 9,10-oxide in cultured human cells

scientific article published on April 1997

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scholarly article

1 reference

Europe PubMed Central

26 September 2017

A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (+/-)-anti-benzo[a]pyrene-7,8-diol 9,10-oxide in cultured human cells (English)

1 reference

Europe PubMed Central

26 September 2017

author name string

Hanelt S

1

1 reference

Europe PubMed Central

26 September 2017

Helbig R

2

1 reference

Europe PubMed Central

26 September 2017

Hartmann A

3

1 reference

Europe PubMed Central

26 September 2017

Lang M

4

1 reference

Europe PubMed Central

26 September 2017

Seidel A

5

1 reference

Europe PubMed Central

26 September 2017

Speit G

6

1 reference

Europe PubMed Central

26 September 2017

language of work or name

0 references

publication date

1 April 1997

1 reference

Europe PubMed Central

26 September 2017

Mutation Research

1 reference

Europe PubMed Central

26 September 2017

390

1 reference

Europe PubMed Central

26 September 2017

1-2

1 reference

Europe PubMed Central

26 September 2017

179-188

1 reference

Europe PubMed Central

26 September 2017

Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides

1 reference

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Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

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Biomarkers and molecular epidemiology in mutation/cancer research

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32P-postlabeling methods for DNA adduct detection: overview and critical evaluation

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The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay).

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Characterization of spontaneous and induced mutations in SV40-transformed normal and ataxia telangiectasia cell lines

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The effect of neighbouring bases on G-specific DNA cleavage mediated by treatment with the anti-diol epoxide of benzo[a]pyrene in vitro.

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Sequence preferences of covalent DNA binding by anti-(+)- and anti-(-)-benzo[a]pyrene diol epoxides

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DNA adducts as a measure of lung cancer risk in humans exposed to polycyclic aromatic hydrocarbons

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International Commission for Protection Against Environmental Mutagens and Carcinogens. Working paper no. 3. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo

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Carcinogen-DNA adducts and gene mutation in foundry workers with low-level exposure to polycyclic aromatic hydrocarbons.

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32P-postlabeling analysis of DNA adducts in different populations

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Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene

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Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts.

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A simple salting out procedure for extracting DNA from human nucleated cells

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7 January 2021

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Measurement by 32P-postlabeling of (±)anti-benzo[a]pyrene-diolepoxide-N2-deoxyguanosine adduct persistence in unstimulated human peripheral blood lymphocytes

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7 January 2021

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Induction of mutations at the hypoxanthine phosphoribosyl transferase (HPRT) locus in AHH-1 human lymphoblastoid cells

1 reference

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7 January 2021

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Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite

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Radical cations in aromatic hydrocarbon carcinogenesis

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7 January 2021

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Minor products from the reaction of (+) and (-) benzo[a]-pyrene-anti-diolepoxide with DNA.

1 reference

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7 January 2021

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The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide can be unstable in double-stranded DNA.

1 reference

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7 January 2021

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Expanded analysis of benzo[a]pyrene-DNA adducts formed in vitro and in mouse skin: their significance in tumor initiation.

1 reference

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7 January 2021

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A simple technique for quantitation of low levels of DNA damage in individual cells

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UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and xeroderma pigmentosum donors in the comet assay: a potential diagnostic technique

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Detection of DNA effects in human cells with the comet assay and their relevance for mutagenesis

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Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene

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Relationship between excision repair and the cytotoxic and mutagenic effect of the 'anti' 7,8-diol-9,10-epoxide of benzo[a]pyrene in human cells

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DNA adducts, mutations and cancer

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AP sites are not significantly involved in mutagenesis by the (+)-anti diol epoxide of benzo[a]pyrene: the complexity of its mutagenic specificity is likely to arise from adduct conformational polymorphism.

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The Major, N2-Gua Adduct of the (+)-anti-Benzo[a]pyrene Diol Epoxide Is Capable of Inducing G.fwdarw.A and G.fwdarw.C, in Addition to G.fwdarw.T, Mutations

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Site-specific rates of excision repair of benzo[a]pyrene diol epoxide adducts in the hypoxanthine phosphoribosyltransferase gene of human fibroblasts: correlation with mutation spectra

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Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,-10-epoxide enantiomers with high and low carcinogenic activity.

1 reference

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Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-ni

1 reference

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1 reference

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1 reference

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1 reference

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Mutations induced in the hypoxanthine phosphoribosyl transferase gene by three urban air pollutants: acetaldehyde, benzo[a]pyrene diolepoxide, and ethylene oxide

1 reference

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Differential mutagenicity and cytotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol and (+/-)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts.

1 reference

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Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1 reference

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Identifiers

10.1016/S0165-1218(97)00019-0

1 reference

Europe PubMed Central

26 September 2017

1 reference

Europe PubMed Central

26 September 2017

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