(Q41143203)

27 September 2017

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title

Transgenic and knockout mice in the study of neurodegenerative diseases (English)

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27 September 2017

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1

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ORCID Public Data File 2021

27 September 2017

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author name string

S Brandner

series ordinal

2

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27 September 2017

S Marino

series ordinal

3

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27 September 2017

J P Steinbach

series ordinal

4

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27 September 2017

publication date

1 March 1996

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Journal of Molecular Medicine

27 September 2017

published in

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27 September 2017

volume

74

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27 September 2017

issue

3

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27 September 2017

page(s)

111-126

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Structural clues to prion replication

27 September 2017

cites work

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12 December 2020

In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat

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12 December 2020

Mice devoid of PrP are resistant to scrapie

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12 December 2020

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

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12 December 2020

Expression of v-src induces aberrant development and twinning in chimaeric mice

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12 December 2020

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

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12 December 2020

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12 December 2020

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

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12 December 2020

Normal host prion protein necessary for scrapie-induced neurotoxicity

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12 December 2020

Gene transfer and molecular cloning of the rat nerve growth factor receptor

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12 December 2020

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

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12 December 2020

Oxidative stress, glutamate, and neurodegenerative disorders

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12 December 2020

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

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12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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12 December 2020

Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis

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12 December 2020

Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice

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12 December 2020

Attenuation of glutamate-induced neuronal swelling and toxicity in transgenic mice overexpressing human CuZn-superoxide dismutase

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12 December 2020

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

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12 December 2020

Targeted oncogene activation by site-specific recombination in transgenic mice

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12 December 2020

Role of the PrP gene in transmissible spongiform encephalopathies

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12 December 2020

p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells

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12 December 2020

The transcriptional transactivator of human foamy virus maps to the bel 1 genomic region

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12 December 2020

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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12 December 2020

A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras

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12 December 2020

Development of disease and virus recovery in transgenic mice containing HIV proviral DNA.

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12 December 2020

Transactivation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by the human foamy virus bel1 protein requires a specific DNA sequence

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12 December 2020

Cell type-specific tumor induction in neural transplants by retrovirus-mediated oncogene transfer

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12 December 2020

Inactivation of the scrapie agent by near monochromatic ultraviolet light

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12 December 2020

The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic mice

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12 December 2020

Making models for Alzheimer's disease.

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12 December 2020

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

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12 December 2020

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

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12 December 2020

Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis

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12 December 2020

Vacuolar myelopathy with multinucleated giant cells in the acquired immune deficiency syndrome (AIDS). Light and electron microscopic distribution of human immunodeficiency virus (HIV) antigens

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12 December 2020

Multinucleated giant cells in brain: a hallmark of the acquired immune deficiency syndrome (AIDS).

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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12 December 2020

Inherited prion diseases

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12 December 2020

Regulation of HIV gene expression by RNA-protein interactions

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12 December 2020

E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice

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12 December 2020

Degeneration of oxidative muscle fibers in HTLV-1 tax transgenic mice

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12 December 2020

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

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12 December 2020

Molecular biology of prion diseases

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12 December 2020

Identification of a novel SOD1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of Ile113Thr in three others

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12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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12 December 2020

The scrapie agent: "a virus by any other name"

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12 December 2020

Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase

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12 December 2020

Expression of human foamy virus is differentially regulated during development in transgenic mice

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12 December 2020

Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses

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12 December 2020

Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination

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12 December 2020

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.

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12 December 2020

A modified host protein model of scrapie

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12 December 2020

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

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12 December 2020

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

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12 December 2020

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

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12 December 2020

Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sjögren's syndrome

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12 December 2020

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

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12 December 2020

[Neurotoxicity in mice due to cysteine-rich parts of visna virus and HIV-1 Tat proteins]

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12 December 2020

The nature of the scrapie agent: the evolution of the virino

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12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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12 December 2020

Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

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12 December 2020

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

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12 December 2020

Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development.

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12 December 2020

Progressive encephalopathy and myopathy in transgenic mice expressing human foamy virus genes

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12 December 2020

The possible nature of the transmissible agent of scrapie

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12 December 2020

The AMOG/beta 2 subunit of Na,K-ATPase is not necessary for long-term survival of telencephalic grafts

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12 December 2020

Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein

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12 December 2020

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

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12 December 2020

Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection

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12 December 2020

Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene

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12 December 2020

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

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12 December 2020

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

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12 December 2020

Identification of a protein that purifies with the scrapie prion

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12 December 2020

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

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12 December 2020

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

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12 December 2020

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

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12 December 2020

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

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12 December 2020

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

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12 December 2020

Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene

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12 December 2020

Role of PrP in prion diseases

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12 December 2020

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

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12 December 2020

Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome

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12 December 2020

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

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12 December 2020

Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

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12 December 2020

The prion protein gene: a role in mouse embryogenesis?

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12 December 2020

A transgenic mouse model for human neurofibromatosis

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12 December 2020

Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration

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12 December 2020

Spontaneous neurodegeneration in transgenic mice with mutant prion protein

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12 December 2020

Nearly ubiquitous tissue distribution of the scrapie agent precursor protein

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12 December 2020

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

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12 December 2020

Seizures and myoclonus in patients with Alzheimer's disease.

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12 December 2020

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

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12 December 2020

Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

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12 December 2020

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

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12 December 2020

Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis

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12 December 2020

Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line.

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12 December 2020

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

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12 December 2020

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

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12 December 2020

Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF

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12 December 2020

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

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12 December 2020

High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosis

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12 December 2020

Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

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12 December 2020

Human foamy virus: an underestimated neuropathogen?

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12 December 2020

Activation of HIV transcription by human foamy virus in transgenic mice.

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12 December 2020

The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.

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12 December 2020

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

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12 December 2020

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs

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12 December 2020

Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein

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12 December 2020

Dispensable role of the NF-kappa B sites in the UV-induction of the HIV-1 LTR in transgenic mice

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12 December 2020

Tissue- and site-specific DNA recombination in transgenic mice

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12 December 2020

The human desmin gene: a specific regulatory programme in skeletal muscle both in vitro and in transgenic mice.

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12 December 2020

Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.

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12 December 2020

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

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12 December 2020

Genetic aspects of unconventional virus infections: the basis of the virino hypothesis

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12 December 2020

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

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12 December 2020

No propagation of prions in mice devoid of PrP.

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12 December 2020

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

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12 December 2020

Novel proteinaceous infectious particles cause scrapie

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12 December 2020

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

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12 December 2020

Infectious DNA of the Human spumaretrovirus

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12 December 2020

Advanced Alzheimer's disease is a risk factor for late-onset seizures

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12 December 2020

Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome

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12 December 2020

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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12 December 2020

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

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12 December 2020

Does the agent of scrapie replicate without nucleic acid?

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12 December 2020

RESISTANCE OF THE SCRAPIE AGENT TO FORMALIN.

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12 December 2020

The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site

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12 December 2020

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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12 December 2020

Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus

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12 December 2020

GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle

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12 December 2020

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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12 December 2020

The nature of the scrapie agent: the virus theory

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12 December 2020

Nature of the Scrapie Agent

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12 December 2020

The exceptionally small size of the scrapie agent

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12 December 2020

A chimaeric mouse model for autosomal-dominant polycystic kidney disease

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12 December 2020

trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene

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12 December 2020

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

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12 December 2020

Disruption of the CNTF gene results in motor neuron degeneration.

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12 December 2020

Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.

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12 December 2020

Involvement of neurofilaments in motor neuron disease

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12 December 2020

Tumorigenesis in transgenic mice: identification and characterization of synergizing oncogenes

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12 December 2020

Proposed three-dimensional structure for the cellular prion protein

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12 December 2020

Search for a scrapie-specific nucleic acid: a progress report.

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12 December 2020

A cellular gene encodes scrapie PrP 27-30 protein

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12 December 2020

Identifiers

DOI

10.1007/BF01575443

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27 September 2017

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