(Q41152946)

27 September 2017

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title

The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells (English)

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27 September 2017

D L Eizirik

1

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27 September 2017

M Flodström

series ordinal

2

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27 September 2017

A E Karlsen

series ordinal

3

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27 September 2017

N Welsh

series ordinal

4

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27 September 2017

publication date

1 August 1996

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27 September 2017

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27 September 2017

volume

39

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27 September 2017

issue

8

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27 September 2017

page(s)

875-890

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Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM

27 September 2017

cites work

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12 December 2020

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

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12 December 2020

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats.

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12 December 2020

Polygenic control of autoimmune diabetes in nonobese diabetic mice

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12 December 2020

Liposomal delivery of antioxidant enzymes protects against hydrogen peroxide- but not interleukin-1 beta-induced inhibition of glucose metabolism in rat pancreatic islets

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12 December 2020

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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12 December 2020

Cytokine signaling through nonreceptor protein tyrosine kinases

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12 December 2020

Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism

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12 December 2020

The inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.

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12 December 2020

Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta-induced nitric oxide synthase expression in pancreatic beta cells

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12 December 2020

The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11

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12 December 2020

What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus?

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12 December 2020

Nitric oxide synthase structure and mechanism

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12 December 2020

Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells

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12 December 2020

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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12 December 2020

The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta

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12 December 2020

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

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12 December 2020

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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12 December 2020

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

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12 December 2020

Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase

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12 December 2020

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst

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12 December 2020

Interleukin-1-induced activation of a protein kinase co-precipitating with the type I interleukin-1 receptor in T cells

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12 December 2020

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

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12 December 2020

Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?

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12 December 2020

1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells

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12 December 2020

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide

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12 December 2020

Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17.

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12 December 2020

Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans

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12 December 2020

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

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12 December 2020

The high-output nitric oxide pathway: role and regulation

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12 December 2020

Nitric oxide donors decrease the function and survival of human pancreatic islets

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12 December 2020

Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F.

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12 December 2020

Transforming growth factor-beta inhibits the cytokine-mediated expression of the inducible nitric oxide synthase mRNA in human retinal pigment epithelial cells

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12 December 2020

Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages

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12 December 2020

Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2-->24.31 by fluorescent in situ hybridization.

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12 December 2020

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin

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12 December 2020

Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets

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12 December 2020

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform

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12 December 2020

IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide

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12 December 2020

Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.

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12 December 2020

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

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12 December 2020

Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice

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12 December 2020

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP

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12 December 2020

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

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12 December 2020

Insulin-dependent diabetes mellitus as a beta-cell targeted disease of immunoregulation

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12 December 2020

Endogenous nitric oxide induced by interleukin-1 beta in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay

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12 December 2020

Dissociation between Interleukin-1β-Induced Expression of mRNA for Superoxide-Dismutase and Nitric Oxide Synthase in Insulin-Producing Cells

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12 December 2020

On the expression of nitric oxide synthase by human macrophages. Why no NO?

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12 December 2020

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

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12 December 2020

Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1 beta

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12 December 2020

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

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12 December 2020

Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE)

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12 December 2020

The cytokine responsive vascular smooth muscle cell enhancer of inducible nitric oxide synthase. Activation by nuclear factor-kappa B.

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12 December 2020

Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase

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12 December 2020

Molecular genetic analysis of the duplication of human inducible nitric oxide synthase (NOS2) sequences.

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12 December 2020

Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism

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12 December 2020

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide

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12 December 2020

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production

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12 December 2020

Influence of protease on inhibitory and stimulatory effects of interleukin 1 beta on beta-cell function

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12 December 2020

Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. RNA blot, immunoblot, and immunohistochemical analyses

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12 December 2020

Tyrosine kinase inhibitors, genistein and herbimycin A, do not block interleukin-1 beta-induced activation of NF-kappa B in rat mesangial cells

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12 December 2020

Secretory products of macrophages

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12 December 2020

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte

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12 December 2020

Interleukin-1 induces rapid and transient expression of the c-fos proto-oncogene in isolated pancreatic islets and in purified beta-cells

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12 December 2020

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

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12 December 2020

Structural diversity in the 5'-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA.

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12 December 2020

Ceramide activates the stress-activated protein kinases

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12 December 2020

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

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12 December 2020

Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis

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12 December 2020

Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney

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12 December 2020

New insights into the regulation of inducible nitric oxide synthesis

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12 December 2020

Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA

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12 December 2020

N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase

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12 December 2020

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

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12 December 2020

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus

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12 December 2020

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line

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12 December 2020

Strain-Dependent Differences in Sensitivity of Rat -Cells to Interleukin 1 In Vitro and In Vivo

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12 December 2020

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme

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12 December 2020

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes

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12 December 2020

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta

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12 December 2020

Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility

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12 December 2020

Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic beta-cells

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12 December 2020

Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function

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12 December 2020

Interleukin-1β Increases the Biosynthesis of the Heat Shock Protein hsp70 and Selectively Decreases the Biosynthesis of five Proteins in rat Pancreatic Islets

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12 December 2020

Molecular cloning and characterization of human endothelial nitric oxide synthase

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12 December 2020

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

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12 December 2020

Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets

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12 December 2020

Nitric oxide activates cyclooxygenase enzymes.

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12 December 2020

Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic beta-cells

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12 December 2020

Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter

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12 December 2020

Localization of the human gene for inducible nitric oxide synthase (NOS2) to chromosome 17q11.2-q12

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12 December 2020

Islet cell DNA is a target of inflammatory attack by nitric oxide

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12 December 2020

A role for tyrosine kinase activation in interleukin-1 beta induced nitric oxide production in the insulin producing cell line RINm-5F.

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12 December 2020

Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular homeostasis

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12 December 2020

The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein

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12 December 2020

Interleukin-1β induces the expression of HSP70, heme oxygenase and Mn-SOD in FACS-purified rat islet β-cells, but not in α-cells

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12 December 2020

Nitric oxide: a physiologic messenger

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12 December 2020

Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.

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12 December 2020

IRAK: a kinase associated with the interleukin-1 receptor

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12 December 2020

Arginine metabolism in wounds

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12 December 2020

Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells

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12 December 2020

Mapping of the Genes Encoding Human Inducible and Endothelial Nitric Oxide Synthase (NOS2 and NOS3) to the Pericentric Region of Chromosome 17 and to Chromosome 7, Respectively

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12 December 2020

Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide.

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12 December 2020

Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro

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12 December 2020

Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: induction of argininosuccinate synthetase by cytokines

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12 December 2020

Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1 beta (IL-1 beta) without affecting glutamate decarboxylase expression or nitric oxide production

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12 December 2020

Increased intracellular Ca2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability

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12 December 2020

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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12 December 2020

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

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12 December 2020

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction

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12 December 2020

Insulin-secreting beta-cells possess specific receptors for interleukin-1 beta

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12 December 2020

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

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12 December 2020

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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12 December 2020

The L-arginine-nitric oxide pathway

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12 December 2020

Altered immune responses in mice lacking inducible nitric oxide synthase

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12 December 2020

Nicotinamide Decreases Nitric Oxide Production and Partially Protects Human Pancreatic Islets Against the Suppressive Effects of Combinations of Cytokines

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12 December 2020

Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide

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12 December 2020

A natural interleukin 1 (IL-1) inhibitor counteracts the inhibitory effect of IL-1 on insulin production in cultured rat pancreatic islets

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12 December 2020

Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation

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12 December 2020

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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12 December 2020

Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B.

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12 December 2020

NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity.

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12 December 2020

Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis

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12 December 2020

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase

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12 December 2020

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages

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12 December 2020

An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1?

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12 December 2020

Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide

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12 December 2020

Role of endothelium-derived nitric oxide in the regulation of blood pressure

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12 December 2020

The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits

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12 December 2020

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death

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12 December 2020

Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1

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12 December 2020

Interleukin-10 stimulates rat pancreatic islets in vitro, but fails to protect against interleukin-1.

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12 December 2020

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages

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12 December 2020

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide

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12 December 2020

Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production

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12 December 2020

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

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12 December 2020

Nitric oxide synthases: properties and catalytic mechanism

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12 December 2020

Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans.

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12 December 2020

Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide

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12 December 2020

Nitric oxide: first in a new class of neurotransmitters

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12 December 2020

Messenger RNA degradation in eukaryotes

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12 December 2020

Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats

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12 December 2020

A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages

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12 December 2020

Transcription factor ATF2 regulation by the JNK signal transduction pathway

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12 December 2020

Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

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12 December 2020

Recombinant human transforming growth factor beta does not inhibit the effects of interleukin-1 beta on pancreatic islet cells

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12 December 2020

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

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12 December 2020

Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells

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12 December 2020

TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown

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12 December 2020

Nitric oxide synthase: expression and expressional control of the three isoforms.

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12 December 2020

Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism

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12 December 2020

Interleukin-1 beta regulates the expression of a leukocyte type of 12-lipoxygenase in rat islets and RIN m5F cells

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12 December 2020

Calmodulin is a subunit of nitric oxide synthase from macrophages

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12 December 2020

Modulation of inducible nitric oxide synthase in RINm5F cells

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12 December 2020

Natural resistance and nitric oxide

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12 December 2020

Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine

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12 December 2020

Interleukin-1 beta induced activation of NF-kappa B in insulin producing RINm5F cells is prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone

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12 December 2020

TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide

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12 December 2020

Type 1 (insulin-dependent) diabetes mellitus and nitric oxide

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12 December 2020

Nitric oxide limits transcriptional induction of nitric oxide synthase in CNS glial cells

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12 December 2020

Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells.

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12 December 2020

Inducible nitric-oxide-synthase mRNA is transiently expressed and destroyed by a cycloheximide-sensitive process

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12 December 2020

Identifiers

DOI

10.1007/S001250050528

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27 September 2017

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