(Q41154272)

27 September 2017

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title

Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system (English)

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27 September 2017

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reactive oxygen species

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V Darley-Usmar

1

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27 September 2017

B Halliwell

series ordinal

2

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27 September 2017

publication date

1 May 1996

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27 September 2017

published in

Pharmaceutical Research

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27 September 2017

volume

13

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27 September 2017

issue

5

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27 September 2017

page(s)

649-662

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Interactions of human blood plasma with hydrogen peroxide and hypochlorous acid.

27 September 2017

cites work

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12 December 2020

Generation of superoxide anion by brain endothelial cell xanthine oxidase

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12 December 2020

Role of Ca2+ in toxic cell killing

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12 December 2020

Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophages

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12 December 2020

The reaction of no with superoxide

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12 December 2020

Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation

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12 December 2020

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases

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12 December 2020

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance

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12 December 2020

An NADPH oxidase superoxide-generating system in the rabbit aorta

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12 December 2020

Hydrogen peroxide stimulates sodium-potassium pump activity in cultured pulmonary arterial endothelial cells

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12 December 2020

Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein

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12 December 2020

Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage

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12 December 2020

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

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12 December 2020

Potentiation of nitric oxide-mediated vascular relaxation by SC52608, a superoxide dismutase mimic

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12 December 2020

Superoxide and peroxynitrite in atherosclerosis

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12 December 2020

Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein

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12 December 2020

Repair of oxidative damage to DNA: enzymology and biology

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12 December 2020

Metal ions catalytic for free radical reactions in the plasma of patients with fulminant hepatic failure

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12 December 2020

Xanthine oxidase-induced injury to endothelium: role of intracellular iron and hydroxyl radical

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12 December 2020

Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils

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12 December 2020

DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems

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12 December 2020

Circulating xanthine oxidase in human ischemia reperfusion

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12 December 2020

Minimally modified low density lipoprotein is biologically active in vivo in mice

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12 December 2020

Effect of probucol treatment on the susceptibility of low density lipoprotein isolated from hypercholesterolemic patients to become oxidatively modified in vitro

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12 December 2020

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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12 December 2020

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit

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12 December 2020

Xanthine oxidase activity in the circulation of rats following hemorrhagic shock

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12 December 2020

Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

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12 December 2020

Hydrogen peroxide activates agonist-sensitive Ca(2+)-flux pathways in canine venous endothelial cells

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12 December 2020

Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions.

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12 December 2020

Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophages

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12 December 2020

Increased superoxide anion release from human endothelial cells in response to cytokines

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12 December 2020

Hydrogen peroxide at low concentrations strongly enhances the inhibitory effect of nitric oxide on platelets

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12 December 2020

Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low-density lipoprotein

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12 December 2020

Approaches toward selective inhibition of nitric oxide synthase

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12 December 2020

Superoxide mediates reperfusion-induced leukocyte-endothelial cell interactions

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12 December 2020

Nitric oxide and oxygen radicals: a question of balance

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12 December 2020

Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells

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12 December 2020

Evidence for the activation of the signal-responsive phospholipase A2 by exogenous hydrogen peroxide

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12 December 2020

Clinical trials of antioxidants in atherosclerosis: are we doing the right thing?

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12 December 2020

Lipid peroxidation in relation to prostacyclin and thromboxane physiology and pathophysiology

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12 December 2020

Oxidation of methyl linoleate in aqueous dispersions induced by copper and iron

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12 December 2020

Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor

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12 December 2020

P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo

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12 December 2020

Superoxide dismutases. An adaptation to a paramagnetic gas.

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12 December 2020

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

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12 December 2020

Paradoxical fate and biological action of peroxynitrite on human platelets

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12 December 2020

Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation

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12 December 2020

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity

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12 December 2020

Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase

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12 December 2020

Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques

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12 December 2020

Endothelial superoxide production in buffer perfused rat lungs, demonstrated by a new histochemical technique

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12 December 2020

Rapid superoxide production by endothelial cells and their injury upon reperfusion.

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12 December 2020

Enhanced LDL oxidation in uremic patients: an additional mechanism for accelerated atherosclerosis?

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12 December 2020

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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12 December 2020

Bovine aortic endothelial cells release hydrogen peroxide

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12 December 2020

Insight into the nature and site of oxygen-centered free radical generation by endothelial cell monolayers using a novel spin trapping technique

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12 December 2020

Inhibition of oxygen toxicity by targeting superoxide dismutase to endothelial cell surface

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12 December 2020

Nitric oxide prevents leukocyte adherence: role of superoxide

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12 December 2020

Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical

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12 December 2020

Human umbilical vein endothelial cell killing by activated neutrophils. Loss of sensitivity to injury is accompanied by decreased iron content during in vitro culture and is restored with exogenous iron.

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12 December 2020

Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs

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12 December 2020

Metal Ion Release from Mechanically-Disrupted Human Arterial Wall. Implications for the Development of Atherosclerosis

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12 December 2020

DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products

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12 December 2020

Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective

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12 December 2020

Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline

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12 December 2020

Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene

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12 December 2020

Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species

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12 December 2020

The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy

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12 December 2020

Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils

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12 December 2020

Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry

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12 December 2020

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

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12 December 2020

The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion.

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12 December 2020

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

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12 December 2020

Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content

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12 December 2020

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells

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12 December 2020

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor

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12 December 2020

Vascular cells under peroxide induced oxidative stress: a balance study on in vitro peroxide handling by vascular endothelial and smooth muscle cells

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12 December 2020

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases

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12 December 2020

Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation

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12 December 2020

Effects of oxyradicals on oxymyoglobin. Deoxygenation, haem removal and iron release

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12 December 2020

Endogenous xanthine oxidase does not significantly contribute to vascular endothelial production of reactive oxygen species

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12 December 2020

Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils

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12 December 2020

Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.

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12 December 2020

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

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12 December 2020

Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals

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12 December 2020

Cytosolic free Ca2+ and proteolysis in lethal oxidative injury in endothelial cells

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12 December 2020

Agonist-induced peroxynitrite production from endothelial cells

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12 December 2020

Human Fibroblasts Release Reactive Oxygen Species in Response to Treatment with Synovial Fluids from Patients Suffering from Arthritis

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12 December 2020

Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance

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12 December 2020

Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts

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12 December 2020

Human (THP-1) macrophages oxidize LDL by a thiol-dependent mechanism

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12 December 2020

Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells

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12 December 2020

The formation of nitric oxide donors from peroxynitrite

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12 December 2020

Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein

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12 December 2020

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

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12 December 2020

Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles

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12 December 2020

Mitochondrial metabolism of a hydroperoxide to free radicals in human endothelial cells: an electron spin resonance spin-trapping investigation.

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12 December 2020

The role of alpha-tocopherol as a peroxyl radical scavenger in human low density lipoprotein

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12 December 2020

Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophages

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12 December 2020

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia

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12 December 2020

Extracts of human atherosclerotic lesions can modify low density lipoproteins leading to enhanced uptake by macrophages

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12 December 2020

Vascular bound recombinant extracellular superoxide dismutase type C protects against the detrimental effects of superoxide radicals on endothelium-dependent arterial relaxation

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12 December 2020

Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane

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12 December 2020

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atheroscleros

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12 December 2020

Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins

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12 December 2020

Hydrogen peroxide alters signal transduction in human endothelial cells.

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12 December 2020

Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A.

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12 December 2020

Endothelial cells as a source of oxygen-free radicals. An ESR study.

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12 December 2020

Free radicals, antioxidants, and human disease: where are we now?

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12 December 2020

The modulation of ferryl myoglobin formation and its oxidative effects on low density lipoproteins by nitric oxide

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12 December 2020

Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo

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12 December 2020

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions

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12 December 2020

Chronic granulomatous disease

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12 December 2020

Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro

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12 December 2020

Oxidant stress enhances adenylyl cyclase activation

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12 December 2020

Oxidized LDL affects multiple atherogenic cellular responses

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12 December 2020

Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion.

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12 December 2020

The B lymphocyte: a newly recognized source of reactive oxygen species with immunoregulatory potential

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12 December 2020

Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome.

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12 December 2020

Effect of probucol dosage on plasma lipid and lipoprotein levels and on protection of low density lipoprotein against in vitro oxidation in humans

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12 December 2020

Spontaneous cancer and its possible relationship to oxygen metabolism

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12 December 2020

Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells

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12 December 2020

Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases.

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12 December 2020

Bleomycin-detectable iron in serum from leukaemic patients before and after chemotherapy. Therapeutic implications for treatment with oxidant-generating drugs

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12 December 2020

Superoxide, iron, vascular endothelium and reperfusion injury

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12 December 2020

Does superoxide underlie the pathogenesis of hypertension?

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12 December 2020

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man

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12 December 2020

Modulation of fibroblast proliferation by oxygen free radicals

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12 December 2020

Inhibition of mitochondrial electron transport by peroxynitrite

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12 December 2020

Lipoprotein oxidation and gene expression in the artery wall. New opportunities for pharmacologic intervention in atherosclerosis

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12 December 2020

Nitric oxide rapidly scavenges tyrosine and tryptophan radicals

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12 December 2020

Mechanisms of endothelial cell injury in acute inflammation.

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12 December 2020

Free radical-induced alterations in endothelial cell function

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12 December 2020

Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein

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12 December 2020

S-nitroso-glutathione inhibits platelet activation in vitro and in vivo

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12 December 2020

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene

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12 December 2020

Molecular mechanisms and therapeutic strategies related to nitric oxide.

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12 December 2020

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages

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12 December 2020

Effect of hypoxia and reoxygenation on the formation and release of reactive oxygen species by porcine pulmonary artery endothelial cells

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12 December 2020

The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein

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12 December 2020

Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans

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12 December 2020

The role of lipid hydroperoxides in the myoglobin-dependent oxidation of LDL

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12 December 2020

The role of lipid peroxidation and antioxidants in oxidative modification of LDL.

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12 December 2020

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide

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12 December 2020

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitrite

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12 December 2020

Vitamin E consumption and the risk of coronary heart disease in men.

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12 December 2020

The behaviour of caeruloplasmin in stored human extracellular fluids in relation to ferroxidase II activity, lipid peroxidation and phenanthroline-detectable copper

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12 December 2020

Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.

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12 December 2020

The pathogenesis of atherosclerosis: a perspective for the 1990s

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12 December 2020

Hypercholesterolemia increases endothelial superoxide anion production

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12 December 2020

L-arginine improves endothelium-dependent vasorelaxation and reduces intimal hyperplasia after balloon angioplasty.

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12 December 2020

Interaction of alpha-tocopherol with copper and its effect on lipid peroxidation

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12 December 2020

Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis

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12 December 2020

Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells

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12 December 2020

Alterations in human vascular endothelial cell function by oxygen free radicals. Platelet adherence and prostacyclin release

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12 December 2020

Aortic antioxidant defence mechanisms: time-related changes in cholesterol-fed rabbits

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12 December 2020

Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid

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12 December 2020

Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species

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12 December 2020

Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein.

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12 December 2020

A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages

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12 December 2020

Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material

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12 December 2020

Tissue destruction by neutrophils

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12 December 2020

Dietary Correction of Hypercholesterolemia in the Rabbit Normalizes Endothelial Superoxide Anion Production

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12 December 2020

Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation

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12 December 2020

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide

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12 December 2020

Low density lipoprotein undergoes oxidative modification in vivo

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12 December 2020

Endogenous oxidative DNA damage, aging, and cancer

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12 December 2020

The reaction of nitric oxide with organic peroxyl radicals

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12 December 2020

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion

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12 December 2020

Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis.

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12 December 2020

Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion

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12 December 2020

Mechanisms of endothelial cell ATP depletion after oxidant injury

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12 December 2020

Nitric oxide as an antioxidant

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12 December 2020

On the limited ability of superoxide to release iron from ferritin

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12 December 2020

Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation

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12 December 2020

Superoxide production by human umbilical vein endothelial cells in an anoxia-reoxygenation model

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12 December 2020

Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man

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12 December 2020

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

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12 December 2020

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

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12 December 2020

Free radicals and antioxidants: a personal view

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12 December 2020

Marked overproduction of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome

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12 December 2020

Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?

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12 December 2020

Role of free radicals and catalytic metal ions in human disease: an overview

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12 December 2020

The primary localization of free radical generation after anoxia/reoxygenation in isolated endothelial cells.

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12 December 2020

Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite

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12 December 2020

Oxidative chemistry of peroxynitrite

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12 December 2020

Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein.

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12 December 2020

Identifiers

DOI

10.1023/A:1016079012214

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27 September 2017

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