(Q41155370)

27 September 2017

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title

Muromonab CD3: a reappraisal of its pharmacology and use as prophylaxis of solid organ transplant rejection (English)

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27 September 2017

M I Wilde

1

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27 September 2017

K L Goa

series ordinal

2

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27 September 2017

publication date

1 May 1996

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27 September 2017

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27 September 2017

volume

51

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27 September 2017

issue

5

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27 September 2017

page(s)

865-894

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Neoplastic disorders after pediatric heart transplantation

27 September 2017

cites work

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12 December 2020

Biphasic granulocytopenia after administration of the first dose of OKT3

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12 December 2020

Post-transplantation lymphoproliferative disorder and OKT3

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12 December 2020

Symptomatic cytomegalovirus disease in the cytomegalovirus antibody seropositive renal transplant recipient treated with OKT3.

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12 December 2020

Accelerated liver allograft rejection during prophylactic immunosuppression with OKT3

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12 December 2020

Mechanisms of action and overview of OKT3.

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12 December 2020

Impact of HLA matching, type of crossmatch, and immunosuppressive therapy on primary pediatric cadaver renal allograft survival

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12 December 2020

Differences in antibody formation to OKT3 between kidney and heart transplantation recipients

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12 December 2020

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12 December 2020

Evidence that pentoxifylline reduces anti-CD3 monoclonal antibody-induced cytokine release syndrome

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12 December 2020

The cardiopulmonary response to OKT3 in orthotopic cardiac transplant recipients

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12 December 2020

Quadruple-drug induction therapy in combined renal and pancreatic transplantation--OKT3 versus ATG

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12 December 2020

D-dimer XDP correlates with fibrinolytic shutdown in renal transplant patients treated with anti-T-cell antibodies

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12 December 2020

Does short-course induction with OKT3 improve outcome after heart transplantation? A randomized trial

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12 December 2020

Induction with OKT3 and prostaglandin E1 in liver transplantation.

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12 December 2020

Immunohistology of liver allografts in recipients managed with prophylactic OKT3

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12 December 2020

Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal antibody in mice by interleukin-10

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12 December 2020

Early postoperative care of the cardiac transplantation patient: routine considerations and immunosuppressive therapy

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12 December 2020

Cancers following thoracic organ transplantation: a single center study

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12 December 2020

Induction immunosuppression with the monoclonal antibody OKT3 after cardiac transplantation

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12 December 2020

A prospective randomized controlled trial of initial immunosuppression with ALG versus OKT3 in recipients of cardiac allografts

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12 December 2020

Interleukin-10 inhibits OKT3-induced cytokine release: in vitro comparison with pentoxifylline

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12 December 2020

Antilymphocyte antibodies in the treatment of allograft rejection: targets, mechanisms of action, monitoring, and efficacy

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12 December 2020

Pretreatment with divided doses of steroids strongly decreases side effects of OKT3

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12 December 2020

The effects of oral pentoxifylline on the cytokine release syndrome during inductive OKT3

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12 December 2020

Prophylactic use of OKT3 in immunologic high-risk cadaver renal transplant recipients

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12 December 2020

Prophylactic therapy for rejection after cardiac transplantation. A comparison of rabbit antithymocyte globulin and OKT3

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12 December 2020

Antimurine antibody to OKT3 in cardiac transplantation: implications for prophylaxis and retreatment of rejection

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12 December 2020

Pulmonary lymphoma in cardiac transplant patients treated with OKT3 for rejection: diagnosis by fine-needle aspiration

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12 December 2020

Activation of coagulation and fibrinolysis following OKT3 administration to renal transplant recipients: association with distinct mediators

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12 December 2020

Cyclosporine vs OKT3 prophylaxis after orthotopic liver transplantation

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12 December 2020

Consensus statement regarding OKT3-induced cytokine-release syndrome and human antimouse antibodies.

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12 December 2020

General aspects of cytokine-release syndrome: timing and incidence of symptoms.

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12 December 2020

A comparison of rabbit antithymocyte serum and OKT3 as prophylaxis against renal allograft rejection.

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12 December 2020

In vivo cell activation following OKT3 administration. Systemic cytokine release and modulation by corticosteroids

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12 December 2020

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12 December 2020

A randomized prospective trial of prophylactic immunosuppression with ATG-fresenius versus OKT3 after renal transplantation.

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12 December 2020

Pharmacokinetic study of orthoclone OKT3 serum levels during treatment of acute renal allograft rejection

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12 December 2020

Use of monoclonal antibodies in human transplantation

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12 December 2020

Single dose OKT3: adverse effects, pharmacokinetics, and anti-OKT3 antibody response.

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12 December 2020

Kinetics of interleukin 6 during OKT3 treatment in renal allograft recipients

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12 December 2020

Hemodynamic response to OKT3 in orthotopic heart transplant recipients: evidence for reversible myocardial dysfunction

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12 December 2020

Activation of human T cells in vivo following treatment of transplant recipients with OKT3.

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12 December 2020

Lymphoproliferative disorder early after cardiac transplantation

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12 December 2020

Cardiac allograft cellular rejection during OKT3 prophylaxis in the absence of sensitization

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12 December 2020

Procoagulant properties of OKT3 at the monocyte level: inhibition by pentoxifylline

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12 December 2020

OKT3-induced cytokine-release syndrome: renal effects (cytokine nephropathy).

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12 December 2020

Induction immunosuppression with antilymphocyte globulin or OKT3 in cadaver kidney transplantation. Results of a single institution prospective randomized trial

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12 December 2020

Successful use of an enhanced immunosuppressive protocol with plasmapheresis for ABO-incompatible mismatched grafts in liver transplant recipients

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12 December 2020

OKT3-induced cytokine-release syndrome: occurrence beyond the second dose and association with rejection severity

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12 December 2020

T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies

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12 December 2020

Use of CD3 antibodies in transplantation and autoimmune diseases

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12 December 2020

Preoperative prophylactic OKT3 vs RATG. A randomized clinical study in heart transplant patients

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12 December 2020

The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging

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12 December 2020

The influence of OKT3 on expression of lymphocyte adhesion molecules in vitro

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12 December 2020

Prevalence of Invasive Cytomegalovirus Disease with Administration of Muromonab Cd-3 in Patients Undergoing Orthotopic Liver Transplantation

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12 December 2020

Prevention of OKT3 nephrotoxicity after kidney transplantation

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12 December 2020

Reduction of morbidity and cytokine release in anti-CD3 MoAb-treated mice by corticosteroids

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12 December 2020

Randomized prospective trial of OKT3 for early prophylaxis of rejection after liver transplantation

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12 December 2020

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12 December 2020

Anti-OKT3 response following prophylactic treatment in paediatric kidney transplant recipients.

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12 December 2020

Immunosuppression by OKT3--induction of programmed cell death (apoptosis) as a possible mechanism of action

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12 December 2020

Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients

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12 December 2020

High-dose methylprednisolone inhibits the OKT3-induced cytokine-related syndrome

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12 December 2020

Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis

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12 December 2020

Immunologic monitoring of OKT3 induction therapy in cardiac allograft recipients

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12 December 2020

Complications of immunosuppressive therapy in transplantation. 2: Specific immunosuppressive agents

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12 December 2020

Complications associated with immunosuppressive therapy and their management

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12 December 2020

Antimurine antibody formation following OKT3 therapy

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12 December 2020

High-dose glucocorticosteroids increase the procoagulant effects of OKT3

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12 December 2020

The clinical role of OKT3.

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12 December 2020

Sequential therapy--a prospective randomized trial of MALG versus OKT3 for prophylactic immunosuppression in cadaver renal allograft recipients

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12 December 2020

OKT3 antibody response study: comparative testing of human antimouse antibody

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12 December 2020

A prospective randomized study of prophylactic OKT3 versus equine antithymocyte globulin after heart transplantation--increased morbidity with OKT3.

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12 December 2020

Comparison of OKT3 with ALG for prophylaxis for patients with acute renal failure after cadaveric renal transplantation

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12 December 2020

Adverse effects of OKT3 therapy: increased risk with impaired renal function.

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12 December 2020

Anti-CD3 monoclonal antibody induction therapy. Immunological equivalency with triple-drug therapy in heart transplantation

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12 December 2020

In vitro studies of endomyocardial biopsies from heart transplant recipients on RATG and OKT3 immunoprophylaxis protocols.

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12 December 2020

Prospective randomized trial of OKT3- versus horse antithymocyte globulin-based immunosuppressive prophylaxis in heart transplantation

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12 December 2020

Comparison of a monoclonal anti-T cell antibody vs ATG as prophylaxis after heart transplantation

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12 December 2020

T cells from patients successfully treated with OKT3 do not react with the T-cell receptor antibody

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12 December 2020

Cardiopulmonary effects of OKT3: determinants of hypotension, pulmonary edema, and cardiac dysfunction.

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12 December 2020

Rapid growth of cutaneous neuroendocrine (Merkel cell) carcinoma during treatment of refractory cardiac allograft rejection with OKT3 monoclonal antibody

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12 December 2020

Cytokine-release syndrome: general risk-factor modification--preparation of high-risk patients for use of OKT3.

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12 December 2020

Kidney transplantation in the older patient

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12 December 2020

Induction of thromboses within renal grafts by high-dose prophylactic OKT3

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12 December 2020

Complications of using OKT3 for induction of immunosuppression in recipients of kidneys from nonheart beating donors

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12 December 2020

Prophylactic polyclonal versus monoclonal antibodies in kidney and pancreas transplantation

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12 December 2020

Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects

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12 December 2020

Variations in serum OKT3 concentration based upon age, sex, transplanted organ, treatment regimen, and anti-OKT3 antibody status

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12 December 2020

Haemolytic uraemic syndrome in a renal transplant recipient during OKT3 therapy

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12 December 2020

Fine needle aspiration biopsy in renal transplant patients on prophylactic OKT3 treatment

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12 December 2020

Activation and increased expression of adhesion molecules on peripheral blood lymphocytes is a mechanism for the immediate lymphocytopenia after administration of OKT3

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12 December 2020

Stimulation of human monocytes by anti-CD3 monoclonal antibody: induction of inflammatory mediator release via immobilization of Fc receptor by adsorbed immunoglobulin and T-lymphocytes

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12 December 2020

Suppression of OKT3-induced tumor necrosis factor alpha formation by pentoxifylline in renal transplant recipients

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12 December 2020

Discordant expression of CD3 and T-cell receptor antigens on lymphocytes from patients treated with OKT3

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12 December 2020

Value of monoclonal antibody OKT3 in solid organ transplantation: a meta-analysis

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12 December 2020

In vivo anti-CD3-driven cell activation. Cellular source of induced tumor necrosis factor, interleukin-1 beta, and interleukin-6

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12 December 2020

Altered specificity of alloreactive cardiac graft-infiltrating cells by prophylactic treatment with OKT3 or horse antilymphocyte globulin

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12 December 2020

Improved results using OKT3 as induction immunosuppression in renal allograft recipients with delayed graft function

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12 December 2020

Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients

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12 December 2020

Encephalopathy following the use of OKT3 in renal allograft transplantation

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12 December 2020

The effects of intraoperative administration of OKT3 during renal transplantation

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12 December 2020

Prevention of rejection and graft loss with an aggressive quadruple immunosuppressive therapy regimen in children and adolescents.

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12 December 2020

Reversible pancytopenia following OKT3. Use in the context of multidrug immunosuppression for kidney allografting

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12 December 2020

Efficacy of low-dose OKT3 as cytolytic induction therapy in heart transplantation

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12 December 2020

A randomized clinical trial of induction therapy with OKT3 in kidney transplantation

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12 December 2020

Current and future application of monoclonal antibodies in clinical immunosuppressive protocols

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12 December 2020

The immunobiology and clinical use of current immunosuppressive therapy for renal transplantation.

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12 December 2020

Symptomatic cytomegalovirus infection in renal transplant recipients given either Minnesota antilymphoblast globulin (MALG) or OKT3 for rejection prophylaxis

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12 December 2020

Lymphoproliferative disease after pediatric liver transplantation

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12 December 2020

A prospective, double-blind, randomized study of high-versus low-dose OKT3 induction immunosuppression in cadaveric renal transplantation

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12 December 2020

Monitoring OKT3 treatment: pharmacodynamic and pharmacokinetic measures

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12 December 2020

OKT3 vs ALG induction therapy in combined pancreas-kidney transplantation

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12 December 2020

Simultaneous development of diffuse immunoblastic lymphoma in recipients of renal transplants from a single cadaver donor: transmission of Epstein-Barr virus and triggering by OKT3.

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12 December 2020

OKT3 prophylaxis in renal grafts with prolonged cold ischemia times: association with improvement in long-term survival

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12 December 2020

Prophylactic OKT3 in renal retransplantation

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12 December 2020

Humoral immune response against OKT3

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12 December 2020

Cytomegalovirus after heart transplantation. Risk factors for infection and death: a multiinstitutional study. The Cardiac Transplant Research Database Group

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12 December 2020

Some aspects of changed histopathologic appearance of acute rejection in cardiac allografts after prophylactic application of OKT3.

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12 December 2020

OKT3 serum levels as a guide for prophylactic therapy: a pilot study in kidney transplant recipients

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12 December 2020

Triple-drug immunosuppression for heart transplantation in infants and children

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12 December 2020

Encephalopathy associated with OKT3 administration. Possible interaction with indomethacin

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12 December 2020

Risk/benefit ratio of perioperative OKT3 in cardiac transplantation

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12 December 2020

Mouse antibody-coated lymphocytes during OKT3 therapy in liver transplantation

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12 December 2020

Transplantation immunology

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12 December 2020

OKT3 monoclonal antibody plasma levels during therapy and the subsequent development of host antibodies to OKT3

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12 December 2020

Pilot study on induction treatment with high-dose OKT3: preliminary observations in kidney transplantation

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12 December 2020

Safety of OKT3 use in the operating room

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12 December 2020

OKT3 induction in pediatric renal transplantation

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12 December 2020

Early recurrence of hemolytic uremic syndrome in a renal transplant recipient during prophylactic OKT3 therapy

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12 December 2020

Low serum OKT3 levels correlate with failure to prevent rejection in orthotopic liver transplant patients.

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12 December 2020

A randomized trial of OKT3-based versus cyclosporine-based immunoprophylaxis after liver transplantation. Long-term results of a European and Australian multicenter study

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12 December 2020

Complement activation during OKT3 treatment: a possible explanation for respiratory side effects

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12 December 2020

Post-transplant lymphoproliferative disorder in renal allograft recipients. Clinical experience and risk factor analysis in a single center

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12 December 2020

Costs of immunosuppressive therapies used in renal transplantation

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12 December 2020

Renal transplantation despite a positive antiglobulin crossmatch with and without prophylactic OKT3

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12 December 2020

Simultaneous quadruple immunosuppression with cyclosporine induction therapy in high risk renal transplant recipients

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12 December 2020

Monoclonal antibodies in prophylactic immunosuppression after liver transplantation. A randomized controlled trial comparing OKT3 and anti-IL-2 receptor monoclonal antibody LO-Tact-1

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12 December 2020

OKT3 for induction immunosuppression in renal transplantation: a comparative study of high versus low doses

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12 December 2020

Prophylactic OKT3 monoclonal antibody versus antilymphocyte globulins: a prospective, randomized study in 148 first cadaver kidney grafts.

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12 December 2020

A randomized clinical trial of prophylactic OKT3 monoclonal antibody in liver allograft recipients

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12 December 2020

Cytokine nephropathy during antilymphocyte therapy

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12 December 2020

CD3 antigen modulation in T-lymphocytes during OKT3 treatment

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12 December 2020

A prospective, randomized comparison of cyclophosphamide and azathioprine for early rejection prophylaxis after cardiac transplantation. Decreased sensitization to OKT3

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12 December 2020

Correlation of CD3+ lymphocyte depletion with rejection and infection in renal transplants.

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12 December 2020

Intragraft monitoring of rejection after prophylactic treatment with monoclonal anti-interleukin-2 receptor antibody (BT563) in heart transplant recipients.

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12 December 2020

The incidence of antibody formation to OKT3 consequent to its use in organ transplantation

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12 December 2020

Comparative trial of immunoprophylaxis with RATG versus OKT3

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12 December 2020

Morbidity of intraoperative OKT3 administration in primary cadaveric renal transplant recipients

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12 December 2020

The long-term effects of prophylactic OKT3 monoclonal antibody in cadaver kidney transplantation--a single-center, prospective, randomized study

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12 December 2020

Infectious complications in 100 consecutive heart transplant recipients

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12 December 2020

Antimicrobial strategies in the care of organ transplant recipients

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12 December 2020

Prevention of adverse clinical outcome by monitoring of cardiac transplant patients for murine monoclonal CD3 antibody (OKT3) sensitization

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12 December 2020

Procoagulant effect of the OKT3 monoclonal antibody: involvement of tumor necrosis factor

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12 December 2020

Comparison of CyA, OKT3, and ATG immunoprophylaxis in human liver transplantation

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12 December 2020

Selective immunosuppression with anti-T cell monoclonal antibodies

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12 December 2020

Prophylactic OKT3: practical considerations for the prevention of first-dose reactions

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12 December 2020

Posttransplant Epstein-Barr virus infection is associated with elevated levels of CD19+ B lymphocytes

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12 December 2020

Consequences of anti-OKT3 antibody development: OKT3 reuse and long-term graft survival

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12 December 2020

The hemodynamic effects of intraoperative injection of muromonab CD3.

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12 December 2020

Nephrotoxicity of anti-CD3 monoclonal antibodies

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12 December 2020

Administration of OKT3 in the operating room.

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12 December 2020

OKT3 immunoprophylaxis in human liver transplantation

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12 December 2020

Increased early mortality in women undergoing cardiac transplantation

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12 December 2020

Prevention and management of the adverse effects associated with immunosuppressive therapy

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12 December 2020

OKT3 therapy for hepatic allograft rejection. Differential response in adults and children

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12 December 2020

Efficacy of rejection prophylaxis with OKT3 in renal transplantation. Collaborative Transplant Study

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12 December 2020

The long-term outcome of OKT3 compared with cyclosporine prophylaxis after liver transplantation

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12 December 2020

Immunologic monitoring with Orthoclone OKT3 therapy

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12 December 2020

OKT3 first-dose reaction: association with T cell subsets and cytokine release

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12 December 2020

The use of OKT3 in combined pancreas-kidney allotransplantation

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12 December 2020

OKT3 monoclonal antibody given for ten versus fourteen days as immunosuppressive prophylaxis in heart transplantation

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12 December 2020

Corticosteroid inhibition of the OKT3-induced cytokine-related syndrome--dosage and kinetics prerequisites

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12 December 2020

OKT3 prophylaxis in liver transplantation

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12 December 2020

Delayed graft function is associated with an increased incidence of occult rejection and results in poorer graft survival

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12 December 2020

Cancers complicating organ transplantation

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12 December 2020

HLA-DR incompatibility predicts heart transplant rejection independent of immunosuppressive prophylaxis

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12 December 2020

Prophylaxis of heart transplant rejection with either antithymocyte globulin-, Minnesota antilymphocyte globulin-, or an OKT3-based protocol

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12 December 2020

A prospective comparison of murine monoclonal CD-3 (OKT3) antibody-based and equine antithymocyte globulin-based rejection prophylaxis in cardiac transplantation. Decreased rejection and less corticosteroid use with OKT3.

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12 December 2020

Murine monoclonal CD3 antibody (OKT3)-based early rejection prophylaxis in pediatric heart transplantation.

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12 December 2020

Muromonab CD3. A review of its pharmacology and therapeutic potential

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12 December 2020

Cardiovascular collapse following orthoclone OKT3 administration: a case report

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12 December 2020

Pneumocystis carinii pneumonia after liver transplantation in adults

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12 December 2020

Anaphylactic shock after retreatment with OKT3 monoclonal antibody

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12 December 2020

Preemptive ganciclovir therapy to prevent cytomegalovirus disease in cytomegalovirus antibody-positive renal transplant recipients. A randomized controlled trial

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12 December 2020

Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients

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12 December 2020

Is the routine use of induction immunosuppression with ALG or OKT3 justified in cadaveric renal transplantation?

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12 December 2020

OKT3 monoclonal antibodies induce interleukin-6 and interleukin-10: a possible cause of lymphoproliferative disorders associated with transplantation.

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12 December 2020

10.2165/00003495-199651050-00010

Identifiers

DOI

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Dimensions Publication ID

27 September 2017

1011032831

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