(Q41163169)

English

The potential of topoisomerase I inhibitors in the treatment of CNS malignancies: report of a synergistic effect between topotecan and radiation

scientific article published on October 1996

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

The potential of topoisomerase I inhibitors in the treatment of CNS malignancies: report of a synergistic effect between topotecan and radiation (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

author name string

J P Lamond

1

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

M P Mehta

2

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

D A Boothman

3

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

publication date

1 October 1996

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

Journal of Neuro-Oncology

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

1-6

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

https://scigraph.springernature.com/pub.10.1007/bf00177437

0 references

Interaction of ionizing radiation with the topoisomerase I poison camptothecin in growing V-79 and HeLa cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The S-phase cytotoxicity of camptothecin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation lethality enhancement with 9-aminocamptothecin: comparison to other topoisomerase I inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentration and timing dependence of lethality enhancement between topotecan, a topoisomerase I inhibitor, and ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticarcinogenic potential of DNA-repair modulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for tumor cell killing by topoisomerase poisons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma and cerebrospinal fluid pharmacokinetic study of topotecan in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Posttreatment exposure to camptothecin enhances the lethal effects of x-rays on radioresistant human malignant melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action of camptothecin on mammalian cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of topoisomerase I inhibitors with radiation in cis-diamminedichloroplatinum(II)-sensitive and -resistant cells in vitro and in the FSAIIC fibrosarcoma in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of topotecan for pediatric patients with malignant solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of radiation-induced neoplastic transformation by beta-lapachone

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damaging and cell cycle effects of the topoisomerase I poison camptothecin in irradiated human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced malignant transformation is accompanied by increased survival recovery after ionizing radiation in Chinese hamster embryo fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of radiation response in human carcinoma cells in vitro and murine fibrosarcoma in vivo by topotecan, an inhibitor of DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of topoisomerase I in mammalian cells following ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of radioimmunotherapy by inhibition of topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of malignant melanoma with camptothecin (NSC-100880)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of spontaneous and experimental metastasis by a new derivative of camptothecin, CPT-11, in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8864997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00177437

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

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