(Q41202514)

English

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

scientific article published on August 2009

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scholarly article

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4 February 2020

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition (English)

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4 February 2020

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ChEBI release 2020-05-28

Soluble epoxide hydrolase

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1

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4 February 2020

author name string

Ravinder Kodela

2

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4 February 2020

Rajkumar Manne

3

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4 February 2020

Krishnam Raju Atcha

4

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4 February 2020

Narender Puli

5

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4 February 2020

Narsimhaswamy Dubasi

6

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4 February 2020

Vijay L Manthati

7

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4 February 2020

Jorge H Capdevila

8

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4 February 2020

Xiu-Yu Yi

9

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4 February 2020

Daniel H Goldman

10

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4 February 2020

Christophe Morisseau

11

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4 February 2020

Bruce D Hammock

12

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4 February 2020

William B Campbell

13

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4 February 2020

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1 August 2009

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4 February 2020

Journal of Medicinal Chemistry

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4 February 2020

52

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4 February 2020

16

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4 February 2020

5069-5075

1 reference

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4 February 2020

Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Vascular cytochrome p450 enzymes: physiology and pathophysiology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Action of epoxyeicosatrienoic acids on cellular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

New insights regarding the autoxidation of polyunsaturated fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Potent urea and carbamate inhibitors of soluble epoxide hydrolases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

cDNA cloning and expression of a soluble epoxide hydrolase from human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Enzyme-bound pentadienyl and peroxyl radicals in purple lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

28 September 2017

Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

14 June 2018

Inhibition of epoxide metabolism by alpha,beta-epoxyketones and isosteric analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

14 June 2018

Affinity purification of cytosolic epoxide hydrolase using derivatized epoxy-activated Sepharose gels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

14 June 2018

Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Epoxyeicosatrienoic acids activate K+ channels in coronary smooth muscle through a guanine nucleotide binding protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

14(R),15(S)-epoxyeicosatrienoic acid (14(R),15(S)-EET) receptor in guinea pig mononuclear cell membranes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Phospholipid bilayers enhance the stability of leukotriene A4 and epoxytetraenes: stabilization of eicosanoids by liposomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888647

19 August 2018

Synthesis and biological activity of novel epothilone aziridines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carcinogenicity of isosters of epoxides and lactones: aziridine ethanol, propane sultone, and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of epoxyeicosatrienoic acids and heteroatom analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

20-HETE relaxes bovine coronary arteries through the release of prostacyclin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s

1 reference

https://pubmed.ncbi.nlm.nih.gov/19653681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM900634W

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4 February 2020

1 reference

Europe PubMed Central

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4 February 2020

1 reference

Europe PubMed Central

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4 February 2020

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