(Q41211055)

28 September 2017

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title

Importance of the Bcl-2 family in cell death regulation (English)

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28 September 2017

T J McDonnell

1

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28 September 2017

A Beham

2

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28 September 2017

M Sarkiss

3

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28 September 2017

M M Andersen

4

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28 September 2017

P Lo

5

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28 September 2017

publication date

1 October 1996

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28 September 2017

number of pages

10

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inferred from page(s)

published in

Experientia

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28 September 2017

volume

52

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28 September 2017

issue

10-11

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28 September 2017

page(s)

1008-1017

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

28 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF01920110

Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920110

A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920110

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920110

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920110

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

1 reference

12 December 2020

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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12 December 2020

BCL-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein

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12 December 2020

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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12 December 2020

Cell division versus cell death: a functional model of multistep neoplasia

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12 December 2020

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.

1 reference

12 December 2020

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes

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12 December 2020

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

1 reference

12 December 2020

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1 reference

12 December 2020

Nuclear calcium transport and the role of calcium in apoptosis

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12 December 2020

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis

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12 December 2020

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

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12 December 2020

Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes

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12 December 2020

Presence of the long and the short forms of Bcl-X in several human and murine tissues

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12 December 2020

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

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12 December 2020

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

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12 December 2020

Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes

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12 December 2020

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1 reference

12 December 2020

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

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12 December 2020

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis

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12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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12 December 2020

Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone.

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12 December 2020

High expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas

1 reference

12 December 2020

Immunohistochemical analysis of in vivo patterns of Bcl-X expression

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12 December 2020

Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2.

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12 December 2020

The role of bcl-XL in CD40-mediated rescue from anti-mu-induced apoptosis in WEHI-231 B lymphoma cells

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12 December 2020

bcl-2 protein expression in aged brain and neurodegenerative diseases

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12 December 2020

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production

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12 December 2020

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2

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12 December 2020

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

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12 December 2020

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

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12 December 2020

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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12 December 2020

Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: evidence for a novel mechanism of regulating Bcl-2 family protein function

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12 December 2020

Induction of apoptosis by the Bcl-2 homologue Bak

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12 December 2020

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

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12 December 2020

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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12 December 2020

Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases

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12 December 2020

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs

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12 December 2020

Overexpression of the Bcl-2 Protein Increases the Half-life of p21Bax

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12 December 2020

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

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12 December 2020

Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells

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12 December 2020

Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes

1 reference

12 December 2020

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

1 reference

12 December 2020

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

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12 December 2020

Primitive human hematopoietic precursors express Bcl-x but not Bcl-2

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12 December 2020

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

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12 December 2020

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme

1 reference

12 December 2020

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

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12 December 2020

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes

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12 December 2020

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

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12 December 2020

The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours

1 reference

12 December 2020

Bcl-2 and the regulation of programmed cell death

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12 December 2020

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

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12 December 2020

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells

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12 December 2020

The functional basis of c-myc and bcl-2 complementation during multistep lymphomagenesis in vivo

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12 December 2020

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

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12 December 2020

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

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12 December 2020

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

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12 December 2020

Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

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12 December 2020

Involvement of the bcl-2 gene in human follicular lymphoma

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12 December 2020

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

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12 December 2020

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

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12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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12 December 2020

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death

1 reference

12 December 2020

Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease.

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12 December 2020

bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation.

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12 December 2020

Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis

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12 December 2020

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

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12 December 2020

Heterodimerization with Bax is required for Bcl-2 to repress cell death

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12 December 2020

Bax-independent inhibition of apoptosis by Bcl-XL.

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12 December 2020

Genetic control of programmed cell death in the nematode C. elegans.

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12 December 2020

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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12 December 2020

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death

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12 December 2020

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL.

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12 December 2020

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1 reference

12 December 2020

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1 reference

12 December 2020

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

12 December 2020

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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12 December 2020

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells

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12 December 2020

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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12 December 2020

Chromosome 1 aberrations in cancer

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12 December 2020

Bcl-2 and thermotolerance cooperate in cell survival.

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12 December 2020

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.

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12 December 2020

Bcl-2 expressed using a retroviral vector is localized primarily in the nuclear membrane and the endoplasmic reticulum of chicken embryo fibroblasts

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12 December 2020

Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus.

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12 December 2020

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

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12 December 2020

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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12 December 2020

Programmed cell death and Bcl-2 protection in very low oxygen.

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12 December 2020

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

1 reference

12 December 2020

Mapping of the human BAX gene to chromosome 19q13.3–q13.4 and isolation of a novel alternatively spliced transcript, BAXδ

1 reference

12 December 2020

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

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12 December 2020

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

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12 December 2020

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

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12 December 2020

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma

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12 December 2020

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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12 December 2020

The bcl-2 oncogene: apoptosis and neoplasia

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12 December 2020

Chromosome translocations in human cancer.

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12 December 2020

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme

1 reference

12 December 2020

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1 reference

12 December 2020

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells

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12 December 2020

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

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12 December 2020

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

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12 December 2020

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma

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12 December 2020

Identifiers

DOI

10.1007/BF01920110

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28 September 2017

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