(Q412285)

English

Dystrophin

mammalian protein found in Homo sapiens

uniprot:P11532
dystrophin
truncated dystrophin
DMD

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

CH domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

WW domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Zinc finger, ZZ-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-hand domain, type 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-hand domain, type 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

Calponin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WW domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Actinin-type actin-binding domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Spectrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Spectrin/alpha-actinin, protein family

1 reference

based on heuristic

inferred from protein domain or family

427 kilodalton

0 references

time of discovery or invention

1987

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nitric-oxide synthase binding

determination method

1 reference

8 April 2019

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

vinculin binding

determination method

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

protein binding

determination method

8 references

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Interactions of intermediate filament protein synemin with dystrophin and utrophin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Syntrophin binds to an alternatively spliced exon of dystrophin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

4 references

8 April 2019

The 'spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

structural constituent of muscle

determination method

structural constituent of cytoskeleton

determination method

1 reference

8 April 2019

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

postsynaptic membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

lateral plasma membrane

determination method

1 reference

8 April 2019

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

cell-substrate junction

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

dystrophin-associated glycoprotein complex

determination method

3 references

8 April 2019

Dystrophin: the long and short of it

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Identification and characterization of the dystrophin anchoring site on beta-dystroglycan

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

actin cytoskeleton

determination method

1 reference

27 March 2018

Dystrophin Dp71: the smallest but multifunctional product of the Duchenne muscular dystrophy gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

8 April 2019

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

syntrophin complex

determination method

1 reference

8 April 2019

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

neuron projection terminus

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

filopodium membrane

determination method

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

biological process

response to muscle stretch

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

regulation of ryanodine-sensitive calcium-release channel activity

determination method

1 reference

8 April 2019

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

regulation of voltage-gated calcium channel activity

determination method

1 reference

8 April 2019

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

cardiac muscle contraction

determination method

1 reference

8 April 2019

High incidence of electrocardiogram abnormalities in young patients with duchenne muscular dystrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

muscle cell cellular homeostasis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

determination method

1 reference

8 April 2019

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

peptide biosynthetic process

determination method

1 reference

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

muscle organ development

determination method

1 reference

8 April 2019

Expression of recombinant dystrophin and its localization to the cell membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

regulation of heart rate

determination method

1 reference

8 April 2019

High incidence of electrocardiogram abnormalities in young patients with duchenne muscular dystrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

positive regulation of neuron differentiation

determination method

1 reference

27 March 2018

Dystrophin Dp71 is required for neurite outgrowth in PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

determination method

negative regulation of peptidyl-serine phosphorylation

determination method

1 reference

8 April 2019

Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

positive regulation of neuron projection development

determination method

1 reference

27 March 2018

Dystrophin Dp71 is required for neurite outgrowth in PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

determination method

muscle filament sliding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

positive regulation of sodium ion transmembrane transporter activity

determination method

1 reference

8 April 2019

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

regulation of cellular response to growth factor stimulus

determination method

1 reference

27 March 2018

Dystrophin Dp71 is required for neurite outgrowth in PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

determination method

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

determination method

1 reference

8 April 2019

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

motile cilium assembly

determination method

1 reference

27 March 2018

Dystrophin Dp71: the smallest but multifunctional product of the Duchenne muscular dystrophy gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

determination method

regulation of skeletal muscle contraction

determination method

1 reference

8 April 2019

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

determination method

1 reference

8 April 2019

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

cytoskeleton organization

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

determination method

150 nanometre

0 references

Gene Atlas image

PBB GE DMD 203881 s at fs.png
732 × 530; 10 KB

0 references

http://purl.uniprot.org/uniprot/P11532

1 reference

Identifiers.org

Spectrin/alpha-actinin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

Spectrin repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

Zinc finger, ZZ-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

EF-hand domain, type 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

EF-hand domain, type 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

Calponin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

Actinin-type actin-binding domain, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11532

Commons category

Dystrophin

0 references

Identifiers

MeSH descriptor ID

subject named as

Dystrophin

0 references

D12.776.210.500.250

0 references

D12.776.220.250

0 references

D12.776.543.250

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000354464

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354464

ENSP00000367974

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367974

ENSP00000367997

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367997

ENSP00000367951

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367951

ENSP00000288447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000288447

ENSP00000340057

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340057

ENSP00000350765

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350765

ENSP00000352894

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352894

ENSP00000354923

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354923

ENSP00000367948

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367948

ENSP00000367977

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367977

ENSP00000367979

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367979

ENSP00000388559

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388559

ENSP00000395904

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000395904

ENSP00000399897

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399897

ENSP00000417075

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417075

ENSP00000417123

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417123

ENSP00000417725

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417725

ENSP00000444119

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444119

ENSP00000478150

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478150

ENSP00000479270

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479270

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(19 entries)

arwiki ديستروفين
bswiki Distrofin
cawiki Distrofina
cswiki Dystrofin
cywiki DMD
dewiki Dystrophin
enwiki Dystrophin
eswiki Distrofina
frwiki Dystrophine
glwiki Distrofina
hewiki דיסטרופין
itwiki Distrofina
jawiki ジストロフィン
nlwiki Dystrofine
plwiki Dystrofina
ptwiki Distrofina
ruwiki Дистрофин
svwiki Dystrofin
ukwiki Дистрофін

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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