(Q41240502)

28 September 2017

Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition (English)

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28 September 2017

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Grütter MG

1

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28 September 2017

Priestle JP

2

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28 September 2017

Rahuel J

3

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28 September 2017

Grossenbacher H

4

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28 September 2017

Bode W

5

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28 September 2017

Hofsteenge J

6

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28 September 2017

Stone SR

7

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28 September 2017

language of work or name

English

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publication date

1 August 1990

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28 September 2017

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28 September 2017

9

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28 September 2017

8

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28 September 2017

2361-2365

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Crystallographic R factor refinement by molecular dynamics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

On the size of the active site in proteases. I. Papain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Resolution of phase ambiguity in macromolecular crystallography

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Hirudins and the role of thrombin: lessons from leeches

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Conformation of recombinant desulfatohirudin in aqueous solution determined by nuclear magnetic resonance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Biochemistry and genetic engineering of hirudin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Thrombin interactions with hirudin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

The complete covalent structure of hirudin. Localization of the disulfide bonds.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Interaction of site specific hirudin variants with alpha-thrombin.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

Point mutations modifying the thrombin inhibition kinetics and antithrombotic activity in vivo of recombinant hirudin

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552259

14 June 2018

1 reference

12 December 2020

Contribution of the N-terminal region of hirudin to its interaction with thrombin

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12 December 2020

Altered specificities of genetically engineered alpha 1 antitrypsin variants

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12 December 2020

The effect of substituting phosphotyrosine for sulphotyrosine on the activity of hirudin

1 reference

12 December 2020

The hirudin-binding site of human alpha-thrombin. Identification of lysyl residues which participate in the combining site of hirudin-thrombin complex

1 reference

12 December 2020

Identification of regions of alpha-thrombin involved in its interaction with hirudin

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12 December 2020

The use of sequence-specific antibodies to identify a secondary binding site in thrombin

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12 December 2020

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12 December 2020

[Biochemical and pharmacological aspects of the thrombin inhibitor hirudin]

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12 December 2020

Distinct binding sites of Ala48-hirudin1-47 and Ala48-hirudin48-65 on alpha-thrombin

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12 December 2020

Identifiers

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28 September 2017

PubMed publication ID

2369893

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