(Q41260373)

28 September 2017

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title

Antitumor diarylsulfonylureas: novel agents with unfulfilled promise (English)

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28 September 2017

P J Houghton

1

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28 September 2017

J A Houghton

series ordinal

2

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28 September 2017

publication date

1 January 1996

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Investigational New Drugs

28 September 2017

published in

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28 September 2017

volume

14

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28 September 2017

issue

3

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28 September 2017

page(s)

271-280

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https://scigraph.springernature.com/pub.10.1007/bf00194530

28 September 2017

exact match

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cites work

Efficacy of sulofenur and a second generation diarylsulfonylurea, N-[5-(2,3-dihydrobenzofuryl)sulfonyl]-N'-(3,4-dichlorophenyl)urea (LY295501), against colon adenocarcinoma xenografts

1 reference

12 December 2020

Diarylsulfonylureas and radiotherapy. I. In vitro studies with N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)-urea (Sulofenur)

1 reference

12 December 2020

Studies on the cellular pharmacology of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)-urea

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12 December 2020

Separation of resistance to antitumor diarylsulfonylurea agents from collateral sensitivity to mitochondrial toxins.

1 reference

12 December 2020

Effects of diarylsulfonylurea antitumor agents on the function of mitochondria isolated from rat liver and GC3/c1 cells

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12 December 2020

Cross-resistance to antitumor diarylsulfonylureas and collateral sensitivity to mitochondrial toxins in a human cell line selected for resistance to the antitumor agent N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea

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12 December 2020

Phase I clinical study of N-[(4-chlorophenyl)amino]carbonyl-2,3-dihydro-1H-indene-5-sulfonamide (LY186641)

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12 December 2020

Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships

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12 December 2020

Evaluation of N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)-urea against xenografts of pediatric rhabdomyosarcoma.

1 reference

12 December 2020

Characterization of the intracellular distribution and binding in human adenocarcinoma cells of N-(4-azidophenylsulfonyl)-N'-(4-chlorophenyl)urea (LY219703), a photoaffinity analogue of the antitumor diarylsulfonylurea sulofenur

1 reference

12 December 2020

Clinical pharmacology of a novel diarylsulfonylurea anticancer agent

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12 December 2020

A phase II study of sulofenur, a novel sulfonylurea, in recurrent epithelial ovarian cancer.

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12 December 2020

Evidence for mitochondrial localization of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea in human colon adenocarcinoma cells

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12 December 2020

Effect of albumin on antitumor activity of diarylsulfonylureas.

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12 December 2020

The isolation of heterokaryons and hybrids by a selective system using irreversible biochemical inhibitors

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12 December 2020

Phase I trial of sulofenur (LY186641) given orally on a daily x 21 schedule

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12 December 2020

Effect of antitumor diarylsulfonylureas on in vivo and in vitro mitochondrial structure and functions.

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12 December 2020

Metabolism and disposition of the anticancer agent sulofenur in mouse, rat, monkey, and human

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12 December 2020

Formation of indenesulfonylureas in the metabolism of the anticancer agent sulofenur in rats, monkeys, and humans

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12 December 2020

Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey

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12 December 2020

Sulofenur cytotoxicity and changes in cytosolic calcium and mitochondrial membrane potential in human colon adenocarcinoma cell lines

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12 December 2020

Proliferation-dependent and -independent cytotoxicity by antitumor diarylsulfonylureas. Indication of multiple mechanisms of drug action.

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12 December 2020

Influence of extracellular pH on the accumulation and cytotoxicity of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea in human cell lines.

1 reference

12 December 2020

N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea, a novel agent equally cytotoxic to nonproliferating human colon adenocarcinoma cells

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00194530

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Dimensions Publication ID

28 September 2017

1030472056

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