(Q41266612)

English

Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells

scientific article published on December 1995

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Statements

scholarly article

1 reference

Europe PubMed Central

28 September 2017

Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells (English)

1 reference

Europe PubMed Central

28 September 2017

Lesch-Nyhan syndrome

0 references

author name string

M Hakoda

1

1 reference

Europe PubMed Central

28 September 2017

Y Hirai

2

1 reference

Europe PubMed Central

28 September 2017

M Akiyama

3

1 reference

Europe PubMed Central

28 September 2017

H Yamanaka

4

1 reference

Europe PubMed Central

28 September 2017

C Terai

5

1 reference

Europe PubMed Central

28 September 2017

N Kamatani

6

1 reference

Europe PubMed Central

28 September 2017

S Kashiwazaki

7

1 reference

Europe PubMed Central

28 September 2017

publication date

1 December 1995

1 reference

Europe PubMed Central

28 September 2017

1 reference

Europe PubMed Central

28 September 2017

96

1 reference

Europe PubMed Central

28 September 2017

6

1 reference

Europe PubMed Central

28 September 2017

674-680

1 reference

Europe PubMed Central

28 September 2017

https://scigraph.springernature.com/pub.10.1007/bf00210298

0 references

Two populations of heterozygote erythrocytes in moderate hypoxanthine guanine phosphoribosyltransferase deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of in vivo-derived thioguanine-resistant human B cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analyses of in vivo hprt mutant T cells from atomic bomb survivors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of the carrier state for an X-linked disorder, the Lesch-Nyhan syndrome, by the use of lymphocyte cloning.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of somatic mutants in man: HPRT mutations in lymphocytes and hemoglobin mutations in erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Observations on the growth in vitro of myeloid progenitor cells and fibroblasts from hemizygotes and heterozygotes for "complete" and "partial" hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency, and their relevance to the pathogenesi

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lesch-Nyhan syndrome: absence of the mutant enzyme in erythrocytes of a heterozygote for both normal and mutant hypoxanthine-guanine phosphoribosyl transferase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Megaloblastic anaemia in the Lesch-Nyhan syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of in vivo HGPRT-deficient mutant cell frequency using a modified method for cloning human peripheral blood T-lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new method for the detection of Lesch-Nyhan heterozygotes by peripheral blood T cell culture using T cell growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased somatic cell mutant frequency in atomic bomb survivors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analyses of a Lesch-Nyhan syndrome mutation (hprtMontreal) by use of T-lymphocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased mutation frequency following treatment with cancer chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analyses of in vivo hypoxanthine-guanine phosphoribosyltransferase mutations in human T-lymphocytes: II. Demonstration of a clonal amplification of hprt mutant T-lymphocytes in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of in vivo mutations in human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA sequence analysis of in vivo hprt mutation in human T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-allele expression at an X-linked hyperuricemia locus in heterozygous human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal B-lymphocyte function in patients with Lesch-Nyhan syndrome and HGPRT deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thioguanine-resistant mutant frequency in T-lymphocytes from a healthy human population

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-linked hypoxanthine-guanine phosphoribosyl transferase deficiency: heterozygote has two clonal populations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of phenotypically different human lymphocytes originating from a single stem cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of hprt gene mutation following anti-cancer treatment in pediatric patients with acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of heterozygous carriers of the Lesch-Nyhan syndrome by electrophoresis of hair root lysates

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous deficiency at autosomal locus aprt in human somatic cells in vivo induced by two different mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of T-cell receptor gene probes to quantify the in vivo hprt mutations in human T-lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene action in the X-chromosome of the mouse (Mus musculus L.)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lesch-Nyhan Syndrome: Rapid Detection of Heterozygotes by Use of Hair Follicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemizygous expression of glucose-6-phosphate dehydrogenase in erythrocytes of heterozygotes for the Lesch-Nyhan syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations affecting RNA splicing in man are detected more frequently in somatic than in germ cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo mutant frequency rises among breast cancer patients after exposure to high doses of gamma-radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8522326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00210298

1 reference

Europe PubMed Central

28 September 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

28 September 2017

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