(Q41283093)

English

Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate

scientific article published on 26 October 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate (English)

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Caren L Freel Meyers

0 references

author name string

Hetalben Patel

1

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Natalia S Nemeria

2

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Leighanne A Brammer

3

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Caren L Freel Meyers

4

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Frank Jordan

5

1 reference

Europe PubMed Central

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29 September 2017

language of work or name

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publication date

26 October 2012

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Europe PubMed Central

PMC publication ID

29 September 2017

Journal of the American Chemical Society

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Europe PubMed Central

PMC publication ID

29 September 2017

134

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Europe PubMed Central

PMC publication ID

29 September 2017

44

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

18374-18379

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Solid-state nuclear magnetic resonance studies delineate the role of the protein in activation of both aromatic rings of thiamin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

1-Deoxy-D-xylulose 5-phosphate synthase catalyzes a novel random sequential mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

Isotope effect, mechanism, and origin of catalysis in the decarboxylation of mandelylthiamin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

Thiamin diphosphate catalysis: enzymic and nonenzymic covalent intermediates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

1 October 2017

Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

14 June 2018

The biogenetic anatomy of vitamin B6. A 13C NMR investigation of the biosynthesis of pyridoxol in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

14 June 2018

The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

19 August 2018

A single-molecule force spectroscopy nanosensor for the identification of new antibiotics and antimalarials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

19 August 2018

Internal return of carbon dioxide in decarboxylation: catalysis of separation and 12C/13C kinetic isotope effects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

19 August 2018

C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

19 August 2018

NMR analysis of covalent intermediates in thiamin diphosphate enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

19 August 2018

Rhodobacter capsulatus 1-deoxy-D-xylulose 5-phosphate synthase: steady-state kinetics and substrate binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494461

19 August 2018

The protonation site of vitamin B1 as determined from natural-abundance 15N nuclear magnetic resonance spectra

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Remarkable stabilization of zwitterionic intermediates may account for a billion-fold rate acceleration by thiamin diphosphate-dependent decarboxylases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CO2 on a tightrope: stabilization, room-temperature decarboxylation, and sodium-induced carboxylate migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of thiamine-catalyzed reactions. Kinetic analysis of the decarboxylation of pyruvate by 3,4-dimethylthiazolium ion in water and ethanol

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of thiamine-catalyzed reactions. Decarboxylation of 2-(1-carboxy-l-hydroxyethyl)-3,4-dimethylthiazolium chloride

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA307315U

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

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