(Q41286489)

English

Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 September 2017

Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

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inferred from title

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author name string

J Fang

1

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Europe PubMed Central

PubMed publication ID

29 September 2017

D Zuo

2

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Europe PubMed Central

PubMed publication ID

29 September 2017

P H Yu

3

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Europe PubMed Central

PubMed publication ID

29 September 2017

publication date

1 October 1995

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Europe PubMed Central

PubMed publication ID

29 September 2017

number of pages

6

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inferred from page(s)

Psychopharmacology

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Europe PubMed Central

PubMed publication ID

29 September 2017

121

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Europe PubMed Central

PubMed publication ID

29 September 2017

3

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Europe PubMed Central

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29 September 2017

373-378

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Europe PubMed Central

PubMed publication ID

29 September 2017

One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic Changes in the Rabbit Pallidum Following Long-Term Haloperidol Administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic method for the detection and quantitation of haloperidol and seven of its metabolites in microsomal preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3H-spiperone binding sites in post-mortem brains from schizophrenic patients: Relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of Nerve Growth Factor on Catecholamine Metabolism in a Human Neuroblastoma Clone (SY5Y)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of the pyridinium metabolite derived from haloperidol in brain tissue, plasma and urine by high-performance liquid chromatography with fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MPTP toxicity: implications for research in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine receptors and the dopamine hypothesis of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrapyramidal symptoms in neuroleptic recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One year treatment with haloperidol or clozapine fails to alter neostriatal D1- and D2-dopamine receptor sensitivity in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tardive dyskinesia, dopamine receptors, and neuroleptic damage to cell membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local glial reaction in the CNS of albino-rats in response to the administration of a neuroleptic drug (butyrophenone).

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinate morphological and biochemical interconversion of human neuroblastoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the metabolism of haloperidol

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8584620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF02246077

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

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