(Q41293004)

29 September 2017

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title

Warfarin withdrawal. Pharmacokinetic-pharmacodynamic considerations (English)

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29 September 2017

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G Palareti

1

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29 September 2017

C Legnani

series ordinal

2

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29 September 2017

publication date

1 April 1996

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Clinical Pharmacokinetics

29 September 2017

published in

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29 September 2017

volume

30

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29 September 2017

issue

4

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29 September 2017

page(s)

300-313

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Oral anticoagulant drugs: pharmacokinetic aspects

29 September 2017

cites work

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12 December 2020

Pharmacokinetic implications of stereoselective changes in plasma-protein binding: warfarin/sulfinpyrazone

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12 December 2020

The mode of action of vitamin K. Identification of gamma-carboxyglutamic acid as a component of prothrombin.

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Studies of the vitamin K-dependent carboxylase and vitamin K epoxide reductase in rat liver

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Treatment of thromboembolic diseases. Criteria for evaluation of studies

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Effect of warfarin on plasma concentrations of vitamin K dependent coagulation factors in patients with stable control and monitored compliance.

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Vitamin K deficiency from dietary vitamin K restriction in humans

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4-Hydroxycoumarin oral anticoagulants: pharmacokinetics-response relationship

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Suppression of plasma-activated factor VII levels by warfarin therapy

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12 December 2020

Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect

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Platelet function in patients with chronic coronary heart disease on long-term anticoagulant therapy: effect of anticoagulant stopping

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High clearance of (S)-warfarin in a warfarin-resistant subject

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12 December 2020

Vitamin K-dependent carboxylation and vitamin K metabolism in liver. Effects of warfarin

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12 December 2020

Kinetics of warfarin absorption in man

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12 December 2020

Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations

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12 December 2020

Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study

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12 December 2020

Age as a determinant of sensitivity to warfarin

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12 December 2020

BEHAVIOUR OF FACTORS II, VII, IX AND X IN BLEEDING COMPLICATIONS DURING LONG-TERM TREATMENT WITH COUMARIN

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12 December 2020

Quantitative and qualitative measurements of K vitamins in human intestinal contents

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12 December 2020

Target-based warfarin pharmacokinetics in the rat: the link with the anticoagulant effect

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12 December 2020

Assessment of hypercoagulable states by measurement of activation fragments and peptides

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12 December 2020

Prothrombin requires two sequential metal-dependent conformational transitions to bind phospholipid. Conformation-specific antibodies directed against the phospholipid-binding site on prothrombin

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12 December 2020

Evaluation of oral anticoagulant therapy by measuring plasma prothrombin fragment 1 + 2

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12 December 2020

Measurement of the (R)- and (S)-isomers of warfarin in patients undergoing anticoagulant therapy

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12 December 2020

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12 December 2020

Plasma hypercoagulability after termination of oral anticoagulants

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12 December 2020

Prothrombin fragment 1 + 2 and intensity of treatment with oral anticoagulants

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12 December 2020

Absolute configurations of the four warfarin alcohols

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12 December 2020

Chronic anticoagulant therapy in recurrent embolism of cardiac origin

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12 December 2020

Temporary discontinuation of warfarin therapy: changes in the international normalized ratio

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12 December 2020

Elevated factor Xa activity in the blood of asymptomatic patients with congenital antithrombin deficiency

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12 December 2020

Fibrinopeptide a (FPA) in patients with acute myocardial infarction

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12 December 2020

Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses

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12 December 2020

Control of anticoagulant therapy. The use of new tests

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12 December 2020

Effect of treatment with low-dose warfarin-aspirin on activated factor VII

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12 December 2020

Measurement of fibrinopeptide A in patients treated with phenprocoumon

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12 December 2020

Warfarin: metabolism and mode of action

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12 December 2020

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

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12 December 2020

Vitamin K metabolism and vitamin K1 status in human liver samples: a search for inter-individual differences in warfarin sensitivity

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12 December 2020

Hypercoagulable state and thromboembolism following warfarin withdrawal in post-myocardial-infarction patients

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12 December 2020

Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid

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12 December 2020

Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin

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12 December 2020

Metabolism of vitamin K and prothrombin synthesis: anticoagulants and the vitamin K--epoxide cycle

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12 December 2020

Studies on the optical enantiomorphs of warfarin in man

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12 December 2020

EFFECT OF SUDDEN WITHDRAWAL OF LONG-TERM ANTICOAGULANT THERAPY ON THE HEPARIN RESISTANCE AND PLASMA FIBRINOGEN LEVEL

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12 December 2020

Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation

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12 December 2020

Population pharmacokinetics of racemic warfarin in adult patients

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12 December 2020

Comparative pharmacokinetics of coumarin anticoagulants XXXII: Interindividual differences in binding of warfarin and dicumarol in rat liver and implications for physiological pharmacokinetic modeling

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12 December 2020

Clinical Pharmacokinetics of Oral Anticoagulants

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12 December 2020

Persistent generation of thrombin after acute myocardial infarction

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12 December 2020

Vitamin K and the oral anticoagulant drugs

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12 December 2020

Vitamin K-dependent carboxylation. Evidence that at least two microsomal dehydrogenases reduce vitamin K1 to support carboxylation

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12 December 2020

Inter-relationship among individual vitamin K-dependent clotting factors at different levels of anticoagulation

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12 December 2020

Factor II, VII, IX and X concentrations in patients receiving long term warfarin

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12 December 2020

EVIDENCE FOR "REBOUND" HYPERCOAGULABILITY AFTER STOPPING ANTICOAGULANTS

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12 December 2020

Markers of procoagulant imbalance in patients with inherited thrombophilic syndromes

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12 December 2020

Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis

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12 December 2020

Persistent activation of coagulation mechanism in unstable angina and myocardial infarction

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12 December 2020

Microsomal warfarin binding and vitamin K 2,3-epoxide reductase.

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12 December 2020

Intrasubject variation of warfarin binding to protein in serum of patients with cardiovascular disease

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12 December 2020

Disposition of warfarin enantiomers and metabolites in patients during multiple dosing with rac-warfarin

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12 December 2020

Pharmacokinetics of warfarin following intravenous administration to man

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12 December 2020

Variations of prothrombin time, factor VII and protein C with a single daily dose of acenocoumarol. Preliminary results.

1 reference

12 December 2020

Activation of blood coagulation after abrupt or stepwise withdrawal of oral anticoagulants--a prospective study

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12 December 2020

Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin

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12 December 2020

Initiation and regulation of tissue factor-dependent blood coagulation

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12 December 2020

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

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12 December 2020

STUDIES ON THE COUMARIN ANTICOAGULANT DRUGS: THE PHARMACODYNAMICS OF WARFARIN IN MAN.

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12 December 2020

Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone

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12 December 2020

The relationship between the vitamin K cycle inhibition and the plasma anticoagulant response at steady-state S-warfarin conditions in the rat

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12 December 2020

Vitamin K Therapy in Severe Liver Disease

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12 December 2020

Protein C response to induction and withdrawal of oral anticoagulant treatment

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12 December 2020

Vitamin K epoxide and quinone reductase activities. Evidence for reduction by a common enzyme

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12 December 2020

EFFECT OF ORAL ANTICOAGULANTS ON FACTORS VII, IX, X, AND II

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12 December 2020

Active metabolites of acenocoumarol: do they contribute to the therapeutic effect?

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12 December 2020

Pathophysiology of vitamin K-deficiency and oral anticoagulants

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12 December 2020

Non-vitamin K-dependent clotting factors during oral anticoagulant treatment

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12 December 2020

Factor VIII: C levels during oral anticoagulation and after its withdrawal

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12 December 2020

The enantiomers of phenprocoumon: pharmacodynamic and pharmacokinetic studies

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12 December 2020

10.2165/00003088-199630040-00003

Identifiers

DOI

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Dimensions Publication ID

29 September 2017

1027977220

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