(Q41363648)

English

Mutagenicity and chromosomal aberrations as an analytical tool for in vitro detection of mammalian enzyme-mediated formation of reactive metabolites

scientific article published on December 30, 1977

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1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

Mutagenicity and chromosomal aberrations as an analytical tool for in vitro detection of mammalian enzyme-mediated formation of reactive metabolites (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A414695

29 June 2022

author name string

H. Greim

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A414695

29 June 2022

D. Bimboes

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A414695

29 June 2022

G. Egert

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A414695

29 June 2022

W. Göggelmann

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A414695

29 June 2022

M. Krämer

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A414695

29 June 2022

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=414695

29 June 2022

publication date

1 December 1977

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

30 December 1977

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=414695

29 June 2022

full work available at URL

http://link.springer.com/content/pdf/10.1007/BF00343283.pdf

Portable Document Format

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

http://link.springer.com/article/10.1007/BF00343283/fulltext.html

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

http://link.springer.com/content/pdf/10.1007/BF00343283

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Archives of Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

1-2

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

159-169

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

The effect of dietary protein deficiency on the ability of isolated hepatic microsomes to alter the mutagenicity of a primary and a secondary carcinogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of styrene in the rat and the stimulatory effect of phenobarbital

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and toxicity of styrene

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbon tetrachloride hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of dimethylnitrosamine and diethyl-nitrosamine to mutagens

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epoxide intermediates in microsomal oxidation of olefins to glycols

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative mutagenicity of N-nitrosamines in a semi-solid and in a liquid incubation system in the presence of rat or human tissue fractions

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical mechanisms of liver injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA repair synthesis of cultured human cells as a rapid bioassay for chemical carcinogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenic activity of cyclophosphamide, ifosfamide, and trofosfamide in different genes of Escherichia coli and Salmonella typhimurium after biotransformation through extracts of rodent liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenic activity of styrene oxide (1,2-epoxyethylbenzene), a presumed styrene metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine [N-(2-chloroethyl) dibenzylamine]

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsomal metabolism of dimethylnitrosamine and the cytochrome P-450 dependency of its activation to a mutagen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of mutagenicity test using Escherichia coli K-12 as indicator organism

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of styrene in liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irreversible protein binding of norethisterone (norethindrone) epoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of cases of angiosarcoma of the liver among vinyl chloride workers in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reaction of nitrite with pesticides. II. Formation, chemical properties and carcinogenic activity of the N-nitroso derivative of N-methyl-1-naphthyl carbamate (carbaryl)

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carcinogen-induced dna repair in primary rat liver cell cultures; a possible screen for chemical carcinogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimethylnitrosamine: formation of mutagenic compounds by interaction with mouse liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolism as a cause of drug toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic Activation of Haloalkanes and Testsin vitrofor Mutagenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Metabolic Activation of Carcinogenic Aromatic Amines and Amides1

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity testing in vitro. II. Use of a microsome - cultured human fibroblast system to study the cytotoxicity of cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A microsome-dependent binding of benzo[a]pyrene to DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitrosocarbaryl: its effect on human DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human lymphocytes as target cells in a metabolizing test system in vitro for detecting potential mutagens

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenicity of primary and secondary carcinogens altered by normal and induced hepatic microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450 Content and the Ability of Liver Microsomes From Patients Undergoing Abdominal Surgery to Alter the Mutagenicity of a Primary and a Secondary Carcinogen2

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiosarcoma of liver in the manufacture of polyvinyl chloride

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bromodeoxyuridine resistance induced in mouse lymphoma cells by microsomal activation of dimethylnitrosamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of mutagenic N-nitroso compounds from the pesticides prometryne, dodine and carbaryl in the presence of nitrite at pH 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of chlorinated ethylenes: dependence of mutagenic effect on electrophilic reactivity of the metabolically formed epoxides

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The formation of carcinogenic nitroso compounds from nitrite and some types of agricultural chemicals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenicity of industrial compounds: styrene and its possible metabolite styrene oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosome aberrations in xeroderma pigmentosum cells exposed to the carcinogens, 4-nitroquinoline-1-oxide and N-methyl-N'-nitrosoguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Induction of malignant tumors in rats by simultaneous feeding of nitrite and secondary amines]

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/414695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer Research

10

33

2983

author name string

P. Czygan

publication date

1973

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Cancer Research

11

34

119

author name string

P. Czygan

publication date

1974

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Cancer Research

17

29

1272

author name string

H. V. Gelboin

publication date

1969

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Journal of Pharmacology and Experimental Therapeutics

28

173

242

author name string

K. C. Leibman

publication date

1970

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Cancer Research

37

30

559

author name string

J. A. Miller

publication date

1970

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Drug Metabolism and Disposition

39

1

418

author name string

J. R. Mitchell

publication date

1973

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

46

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Pharmacological Reviews

47

19

145

author name string

R. O. Recknagel

publication date

1967

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

59

10

203

author name string

R. Watabe

publication date

1968

1 reference

10.1007/BF00343283

https://api.crossref.org/works/10.1007/BF00343283

25 April 2023

Identifiers

10.1007/BF00343283

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

release_nibimjeytjerrahcq5nqyv3vea

1 reference

https://api.fatcat.wiki/v0/release/nibimjeytjerrahcq5nqyv3vea

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 September 2017

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