(Q41388332)

English

Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders

scientific article published on March 1997

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

1 reference

Europe PubMed Central

Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Wagstaff AJ

1

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

Bryson HM

2

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

publication date

1 March 1997

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

53

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

435-452

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

https://scigraph.springernature.com/pub.10.2165/00003495-199753030-00007

0 references

Reduction of centrally-stimulated gastric acid secretion by tizanidine, a new imidazoline derivative, in anesthetized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of tizanidine in the treatment of spasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. North American Tizanidine Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tizanidine, eperisone and afloqualone on feline dorsal horn neuronal responses to peripheral cutaneous noxious and innocuous stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine (DS103-282), a centrally acting muscle relaxant, selectively depresses excitation of feline dorsal horn neurones to noxious peripheral stimuli by an action at α2-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a simple spasticity quantification method: effects of tizanidine on spasticity in patients with sequelae of cerebrovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tizanidine, a central muscle relaxant, upon spinal reflexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of gait and isokinetic movements for evaluation of antispastic drugs or physical therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine treatment of spasticity caused by multiple sclerosis: results of a double-blind, placebo-controlled trial. US Tizanidine Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A case of tizanidine-induced hepatic injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sclerosis therapy. A practical guide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenergic mechanisms involved in muscle relaxation: significance for the treatment of spasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concomitant depression of locus coeruleus neurons and of flexor reflexes by an alpha 2-adrenergic agonist in rats: a possible mechanism for an alpha 2-mediated muscle relaxation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The management of spasticity--a review of options available in rehabilitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlations between dose, plasma concentrations, and antispastic action of tizanidine (Sirdalud).

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of clonidine and a new related imidazoline derivative (tizanidine) on rat gastric mucosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The adrenergic agonist tizanidine has differential effects on flexor reflexes of intact and spinalized rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of tizanidine action on spasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sedative and sympatholytic effects of oral tizanidine in healthy volunteers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective antinociceptive effects of tizanidine (DS 103-282), a centrally acting muscle relaxant, on dorsal horn neurones in the feline spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antinociceptive activity induced by tizanidine and alpha 2-adrenoreceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle restraint in speed controlled voluntary and passive movements

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic effects of oral tizanidine in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The spasmolytic properties of 5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1,3-benzothiadiazole hydrochloride (DS 103-282): a pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spasticity: a review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of some alpha 2-adrenoceptor agonists and antagonists on gastrointestinal transit in mice: influence of morphine, castor oil and glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-blind comparison of single doses of DS103-282, baclofen and placebo for suppression of spasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term treatment with an imidazoline derivative (DS 103--282) (author's transl)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some pharmacological effects of tizanidine on smooth muscle organs and alpha 2-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacological properties of CS-722, a newly synthesized centrally acting muscle relaxant

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by α-adrenergic receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine-induced depression of polysynaptic cutaneous reflexes in nonanesthetized monkeys is mediated by an alpha 2-adrenergic mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The treatment of spasticity in multiple sclerosis: a double-blind clinical trial of a new anti-spastic drug tizanidine compared with baclofen

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine vs. baclofen in the treatment of spasticity in patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of spasticity with tizanidine in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antinociceptive effects of tizanidine, diazepam and eperisone in isolated spinal cord-tail preparations of newborn rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine versus baclofen in the treatment of spasticity in patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine versus baclofen in the treatment of spasticity in multiple sclerosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective depression of synaptic excitation in cat spinal neurones by baclofen: an iontophoretic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of centrally acting myorelaxants on NMDA receptor-mediated synaptic transmission in the immature rat spinal cord in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the centrally acting muscle relaxant tizanidine on spinal reflexes: involvement of descending noradrenergic systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antinociceptive action of tizanidine in mice and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine in the treatment of spasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptozotocin-diabetes attenuates alpha 2-adrenoceptor agonist-induced delay in small intestinal transit in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine--initial pharmacokinetic studies in patients with spasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective depression of synaptic transmission of spinal neurones in the cat by a new centrally acting muscle relaxant, 5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiodazole (DS103-282)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rating system for neurological impairment in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of clonidine and tizanidine on responses of nociceptive neurons in nucleus ventralis posterolateralis of the cat thalamus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substantia nigra: a site of action of muscle relaxant drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of responses of feline dorsal horn neurones to noxious cutaneous stimuli by tizanidine (DS103-282) and noradrenaline: involvement of alpha 2-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (DS 103-282), a novel myotonolytic agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tizanidine in healthy volunteers: double-blind study compared with diazepam and a placebo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative profile of tizanidine in the management of spasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multi-centre, double-blind trial of tizanidine, a new antispastic agent, in spasticity associated with hemiplegia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multi-centre, double-blind trial of a novel antispastic agent, tizanidine, in spasticity associated with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sino-atrial and atrio-ventricular node dysfunction in a case of tizanidine overdose

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of spinal and supraspinal structures in tizanidine-induced antinociceptive action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal interneurone depression by DS103-282.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamics and pharmacokinetics of the oral antispastic agent tizanidine in patients with spinal cord injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tizanidine on morphine physical dependence: attenuation and intensification

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of tizanidine on α1- and α2-adrenoceptors in the peripheral tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A double-blind, placebo-controlled trial of tizanidine in the treatment of spasticity caused by multiple sclerosis. United Kingdom Tizanidine Trial Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A double-blind, long-term study of tizanidine ('Sirdalud') in spasticity due to cerebrovascular lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenytoin-tizanidine interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of orally administered tizanidine in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine and electrophysiologic analysis of spinal control mechanisms in humans with spasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of tizanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological fate of sirdalud in animals and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the effects of two antispastic drugs, tizanidine and baclofen, on synaptic transmission from muscle spindle afferents to spinal interneurones in cats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant actions of DS 103-282. Pharmacological studies in rodents and the baboon, Papio papio

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tizanidine: neuropharmacology and mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tizanidine, a centrally acting muscle relaxant, on motor systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonists of adenosine and alpha-2-adrenoceptors reverse the anticonvulsant effects of tizanidine in DBA/2 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous evaluation of drug effects on both the spinal cord and the descending pathways in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Summary of combined clinical analysis of controlled clinical trials with tizanidine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of tizanidine on body temperature in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of alpha-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/9074844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003495-199753030-00007

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 September 2017

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