(Q41447688)

English

Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression

scientific article published on 14 January 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression (English)

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Berthold Gottgens

7

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

author name string

Rita Ferreira

1

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Dominik Spensberger

2

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Yvonne Silber

3

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Andrew Dimond

4

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Juan Li

5

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Anthony R Green

6

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

language of work or name

0 references

publication date

14 January 2013

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

33

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

1254-1266

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

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Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Context-dependent function of "GATA switch" sites in vivo

1 reference

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1 October 2017

cis-Regulatory remodeling of the SCL locus during vertebrate evolution.

1 reference

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1 October 2017

Reactivation of hepatic EPO synthesis in mice after PHD loss

1 reference

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1 October 2017

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

1 reference

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1 October 2017

Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

1 reference

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1 October 2017

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

1 reference

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1 October 2017

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

1 reference

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1 October 2017

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Deletion of ultraconserved elements yields viable mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects

1 reference

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1 October 2017

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

1 reference

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1 October 2017

MAP17 overexpression is a common characteristic of carcinomas

1 reference

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1 October 2017

The human reticulocyte transcriptome

1 reference

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1 October 2017

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

The essential haematopoietic transcription factor Scl is also critical for neuronal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Differential expression of novel potential regulators in hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Development of definitive endoderm from embryonic stem cells in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

SCL is required for normal function of short-term repopulating hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Analysis of multiple genomic sequence alignments: a web resource, online tools, and lessons learned from analysis of mammalian SCL loci.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

A highly efficient recombineering-based method for generating conditional knockout mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes

1 reference

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The membrane-associated protein pKe#192/MAP17 in human keratinocytes

1 reference

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Analysis of vertebrate SCL loci identifies conserved enhancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

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Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: neural expression is mediated by GATA factor binding sites

1 reference

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Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique.

1 reference

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Transcriptional regulation of the stem cell leukemia gene by PU.1 and Elf-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development

1 reference

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1 October 2017

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Lineage-restricted regulation of the murine SCL/TAL-1 promoter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

The SCL gene product: a positive regulator of erythroid differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

1 October 2017

Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

11 June 2018

Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

11 June 2018

In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

11 June 2018

Transcription of the SCL gene in erythroid and CD34 positive primitive myeloid cells is controlled by a complex network of lineage-restricted chromatin-dependent and chromatin-independent regulatory elements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

11 June 2018

Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

11 June 2018

SCL is coexpressed with GATA-1 in hemopoietic cells but is also expressed in developing brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

11 June 2018

The SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

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Distinct roles of Mdm2 and Mdm4 in red cell production.

1 reference

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Transgenic analysis of the stem cell leukemia +19 stem cell enhancer in adult and embryonic hematopoietic and endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

19 August 2018

Rescue of lethal c-KitW/W mice by erythropoietin

1 reference

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19 August 2018

Expression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

19 August 2018

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

19 August 2018

SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

19 August 2018

An SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

19 August 2018

Distinct mechanisms direct SCL/tal-1 expression in erythroid cells and CD34 positive primitive myeloid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3592016

19 August 2018

A targeted X-linked CMV-Cre line

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319051

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319051

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319051

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01525-12

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

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