(Q41489707)

1 October 2017

1 reference

title

Farnesyltransferase as a target for anticancer drug design (English)

1 reference

1 October 2017

Qian Y

1

1 reference

1 October 2017

Sebti SM

series ordinal

2

1 reference

1 October 2017

Hamilton AD

series ordinal

3

1 reference

1 October 2017

publication date

1 January 1997

1 reference

1 October 2017

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1 October 2017

volume

43

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1 October 2017

issue

1

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1 October 2017

page(s)

25-41

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Ras C-terminal processing enzymes--new drug targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

The biochemistry of ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

ras GTPase activating protein: signal transmitter and signal terminator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Hydrolysis of GTP by p21NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein: use of a single fluorescent probe at the catalytic site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

The neurofibromatosis type 1 gene encodes a protein related to GAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Signal transduction. How receptors turn Ras on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Binding of GAP to activated PDGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Role of phosphatidylinositol kinase in PDGF receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Crystal structure of the mammalian Grb2 adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

The p21 ras C-terminus is required for transformation and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

p21ras is modified by a farnesyl isoprenoid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Protein prenyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Steady-state kinetic mechanism of Ras farnesyl:protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Farnesyl transferase inhibitors: the successes and surprises of a new class of potential cancer chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Inhibitors of Ras farnesyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Synthesis and biological activity of ras farnesyl protein transferase inhibitors. Tetrapeptide analogs with amino methyl and carbon linkages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Pseudodipeptide inhibitors of protein farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

NMR studies of novel inhibitors bound to farnesyl-protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Identification of Ras farnesyltransferase inhibitors by microbial screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

AN UNIDENTIFIED VIRUS WHICH CAUSES THE RAPID PRODUCTION OF TUMOURS IN MICE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Pseudopeptide inhibitors of Ras farnesyl-protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Benzodiazepine peptidomimetic inhibitors of farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Conformation of a heptapeptide substrate bound to protein farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Farnesyl diphosphate-based inhibitors of Ras farnesyl protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Structure, Chemistry, and Biology of Actinoplanic Acids: Potent Inhibitors of Ras Farnesyl-Protein Transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Isolation and structure of chaetomellic acids A and B from Chaetomella acutiseta: farnesyl pyrophosphate mimic inhibitors of ras farnesyl-protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

RPR113228, a Novel Farnesyl Protein Transferase Inhibitor Produced by Chrysosporium lobatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

New compounds of the manumycin group of antibiotics and a facilitated route for their structure elucidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

10'-Desmethoxystreptonigrin, a novel analog of streptonigrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Preussomerins and Deoxypreussomerins: Novel Inhibitors of Ras Farnesyl-Protein Transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Fusidienol: A novel inhibitor of Ras farnesyl-protein transferase from Fusidium griseum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-0282%281997%2943%3A1%3C25%3A%3AAID-BIP4%3E3.0.CO%3B2-2

10.1002/(SICI)1097-0282(1997)43:1<25::AID-BIP4>3.0.CO;2-2

21 January 2018

Identifiers

DOI

1 reference

release_s5q5pke3nndojcke5fnymlglni

1 October 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/s5q5pke3nndojcke5fnymlglni

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference