(Q41521294)

2 October 2017

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title

Toremifene. A review of its pharmacological properties and clinical efficacy in the management of advanced breast cancer (English)

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2 October 2017

Wiseman LR

1

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PubMed ID

9211086

2 October 2017

Goa KL

series ordinal

2

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2 October 2017

1 July 1997

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2 October 2017

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2 October 2017

54

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2 October 2017

1

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2 October 2017

141-160

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https://scigraph.springernature.com/pub.10.2165/00003495-199754010-00014

2 October 2017

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12 December 2020

Mitotic activity, apoptosis and TRPM-2 mRNA expression in DMBA-induced rat mammary carcinoma treated with anti-estrogen toremifene

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12 December 2020

Biodistribution and scintigraphy of 11C-toremifene in rats bearing DMBA-induced mammary carcinoma

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12 December 2020

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12 December 2020

Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation

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12 December 2020

Effect of Toremifene in patients with metastatic melanoma: a phase II study of the EORTC Melanoma Cooperative Group.

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12 December 2020

The effect of Toremifene on the expression of some genes in human mononuclear cells

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12 December 2020

High dose toremifene (240 mg daily) is effective as first line hormonal treatment in advanced breast cancer. An ongoing phase II multicenter Finnish-Latvian cooperative study

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Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

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A phase III comparison of two toremifene doses to tamoxifen in postmenopausal women with advanced breast cancer. Eastern European Study Group

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12 December 2020

Phase I study of toremifene in patients with advanced cancer

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12 December 2020

Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens

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12 December 2020

The effects of anti-estrogen therapy on lymphocyte functions in breast cancer patients

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12 December 2020

Role of hormones in the growth and regression of human breast cancer cells (MCF-7) transplanted into athymic nude mice

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12 December 2020

Influence of age on toremifene pharmacokinetics

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12 December 2020

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A phase I study of toremifene

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Toremifene, a novel antiestrogen, can overcome hsp27-induced drug resistance in human breast cancer cells.

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Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts

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Pharmacokinetics of the novel antiestrogenic agent toremifene in subjects with altered liver and kidney function.

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12 December 2020

Review of the pharmacological properties of toremifene

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12 December 2020

The effect of toremifene therapy on serum immunoglobulin levels in breast cancer

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12 December 2020

Preclinical studies with toremifene as an antitumor agent.

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12 December 2020

Toremifene for recurrent and advanced endometrial carcinoma

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12 December 2020

Tamoxifen and toremifene lower serum cholesterol by inhibition of delta 8-cholesterol conversion to lathosterol in women with breast cancer.

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12 December 2020

Toremifene enhances cell cycle block and growth inhibition by vinblastine in multidrug resistant human breast cancer cells.

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12 December 2020

Selective reversal of vinblastine resistance in multidrug-resistant cell lines by tamoxifen, toremifene and their metabolites.

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12 December 2020

Biochemical and pharmacological effects of toremifene metabolites

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12 December 2020

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12 December 2020

Comparison of DNA reactivity of the polyphenylethylene hormonal agents diethylstilbestrol, tamoxifen and toremifene in rat and hamster liver

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12 December 2020

High- versus standard-dose megestrol acetate in women with advanced breast cancer: a phase III trial of the Piedmont Oncology Association

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12 December 2020

Induction of Transforming Growth Factor β by the Antiestrogens Droloxifene, Tamoxifen, and Toremifene in MCF-7 Cells

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12 December 2020

Conformational studies and electronic structures of tamoxifen and toremifene and their allylic carbocations proposed as reactive intermediates leading to DNA adduct formation

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12 December 2020

[Efficacy and safety of high dose NK 622 (toremifene citrate) in tamoxifen failed patients with breast cancer]

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12 December 2020

Tamoxifen flare in advanced breast cancer

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12 December 2020

Multicenter phase II efficacy trial of toremifene in tamoxifen-refractory patients with advanced breast cancer

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12 December 2020

A new triphenylethylene compound, Fc-1157a. I. Hormonal effects

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12 December 2020

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12 December 2020

Phase II clinical study of toremifene in patients with metastatic breast cancer. Preliminary communication

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12 December 2020

Safety and efficacy of toremifene in breast cancer patients. A phase II study

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12 December 2020

Effects of toremifene and its main metabolites on growth of breast cancer cell lines

1 reference

12 December 2020

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice

1 reference

12 December 2020

Agonistic and antagonistic effects of antiestrogens in different target organs

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12 December 2020

Antiestrogenic potency of toremifene and tamoxifen in postmenopausal women

1 reference

12 December 2020

Phase I clinical and pharmacokinetics study of high-dose toremifene in postmenopausal patients with advanced breast cancer

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12 December 2020

Phase II study of high dose toremifene in advanced breast cancer progressing during tamoxifene treatment

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12 December 2020

Factors predicting the response of patients with advanced breast cancer to endocrine (Megace) therapy

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12 December 2020

Toremifene, a new antiestrogenic compound in the treatment of metastatic mammary cancer. A phase II study

1 reference

12 December 2020

Effects of the antiestrogen toremifene on growth of the human mammary carcinoma cell line MCF-7.

1 reference

12 December 2020

High-performance liquid chromatographic method for the determination of toremifene and its major human metabolites

1 reference

12 December 2020

Toremifene: pharmacologic and pharmacokinetic basis of reversing multidrug resistance.

1 reference

12 December 2020

Assessment of response to therapy in advanced breast cancer

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12 December 2020

Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats

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12 December 2020

Toremifene and its metabolites enhance doxorubicin accumulation in estrogen receptor negative multidrug resistant human breast cancer cells

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12 December 2020

A phase II study of toremifene in carcinoma corporis uteri. Preliminary communication

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12 December 2020

Toremifene and tamoxifen in advanced breast cancer--a double-blind cross-over trial.

1 reference

12 December 2020

Monitoring the chemosensitizing effects of toremifene with flow cytometry in estrogen receptor negative multidrug resistant human breast cancer cells

1 reference

12 December 2020

Pharmacokinetics of toremifene and its metabolites in patients with advanced breast cancer

1 reference

12 December 2020

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12 December 2020

Induction of covalent DNA adducts in rodents by tamoxifen.

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12 December 2020

High dose toremifene in advanced breast cancer resistant to or relapsed during tamoxifen treatment

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12 December 2020

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12 December 2020

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12 December 2020

Antiestrogenic action of toremifene on hormone-dependent, -independent, and heterogeneous breast tumor growth in the athymic mouse

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12 December 2020

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse

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12 December 2020

Effect of antiestrogen regimen on prostacyclin and thromboxane A2 in postmenopausal patients with breast cancer: evidence of significance of hypertension, smoking or previous use of estrogen therapy

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12 December 2020

Antiatherogenic effects of adjuvant antiestrogens: a randomized trial comparing the effects of tamoxifen and toremifene on plasma lipid levels in postmenopausal women with node-positive breast cancer

1 reference

12 December 2020

DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro

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12 December 2020

Pharmacokinetics of toremifene

1 reference

12 December 2020

Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

1 reference

12 December 2020

Clodronate improves bone mineral density in post-menopausal breast cancer patients treated with adjuvant antioestrogens

1 reference

12 December 2020

Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen

1 reference

12 December 2020

Phase I study of the tolerance and pharmacokinetics of toremifene in patients with cancer

1 reference

12 December 2020

Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer

1 reference

12 December 2020

Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients

1 reference

12 December 2020

Epidemiology and primary prevention of cancers of the breast, endometrium, and ovary. A brief overview.

1 reference

12 December 2020

Adjuvant therapy for breast cancer with positive axillary nodes designed according to estrogen receptor status

1 reference

12 December 2020

Inhibition of hormone-dependent and independent breast cancer cell growth in vivo and in vitro with the antiestrogen toremifene and recombinant human interferon-alpha 2

1 reference

12 December 2020

Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastatic breast cancer.

1 reference

12 December 2020

A randomised trial of second-line hormone vs single agent chemotherapy in tamoxifen resistant advanced breast cancer

1 reference

12 December 2020

New hormonal approaches to the treatment of breast cancer

1 reference

12 December 2020

10.2165/00003495-199754010-00014

Identifiers

DOI

1 reference

PubMed ID

9211086

Dimensions Publication ID

2 October 2017

0 references

1 reference

PubMed ID

9211086