(Q41522819)

2 October 2017

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title

The controversy surrounding the pathogenesis of the multiple sclerosis lesion (English)

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2 October 2017

C F Lucchinetti

1

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2 October 2017

M Rodriguez

series ordinal

2

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2 October 2017

language of work or name

English

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publication date

1 July 1997

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2 October 2017

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2 October 2017

volume

72

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2 October 2017

issue

7

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2 October 2017

page(s)

665-678

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Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown

2 October 2017

cites work

1 reference

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7 January 2021

Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

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7 January 2021

Subversion of the immune system by pathogens.

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7 January 2021

Virus-induced autoimmunity: molecular mimicry as a route to autoimmune disease

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7 January 2021

The T lymphocyte in experimental allergic encephalomyelitis

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7 January 2021

MS as autoimmune disease: myelin antigens

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7 January 2021

Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis

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7 January 2021

T cell activation by autoantigens in multiple sclerosis

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7 January 2021

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

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7 January 2021

T cells responsive to myelin basic protein in patients with multiple sclerosis

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7 January 2021

Frequency of MBP and MBP peptide-reactive T cells in the HPRT mutant T-cell population of MS patients

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7 January 2021

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

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7 January 2021

Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein

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7 January 2021

Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis

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7 January 2021

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis

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7 January 2021

Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients

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7 January 2021

T cell receptor peptide therapy for autoimmune disease

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7 January 2021

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions

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7 January 2021

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones

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7 January 2021

What is the basis for HLA-DQ associations with autoimmune disease?

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7 January 2021

Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis

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7 January 2021

A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota

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7 January 2021

Multiple sclerosis: basic concepts and hypothesis

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7 January 2021

Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients.

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7 January 2021

Plaque-associated expression of human herpesvirus 6 in multiple sclerosis

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7 January 2021

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1 reference

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7 January 2021

The T-lymphocyte response against myelin-associated glycoprotein and myelin basic protein in patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Successful treatment of EAE in rhesus monkeys with MHC class II specific monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Multiple sclerosis: immune system molecule expression in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

The pathology of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

T cell subsets in multiple sclerosis. Gradients at plaque borders and differences in nonplaque regions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Immunohistochemical studies of adult human glial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Role of CD8+ T cells in murine experimental allergic encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Theiler's Virus-Induced Demyelination: Prevention by Immunosuppression

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Macrophage populations associated with multiple sclerosis plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Ultrastructure of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Oligodendrocytes in the early course of multiple sclerosis

1 reference

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7 January 2021

Histopathology and the blood-cerebrospinal fluid barrier in multiple sclerosis

1 reference

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7 January 2021

Bone marrow derived elements and resident microglia in brain inflammation.

1 reference

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7 January 2021

Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Microglia in the immune surveillance of the brain: human microglia constitutively express HLA-DR molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Induction of primary T cell responses by human glial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Multiple sclerosis disease activity correlates with gadolinium-enhanced magnetic resonance imaging

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

The fragility of cerebral lysosomes in multiple sclerosis

1 reference

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7 January 2021

Occurrence of oligodendrocytes within astrocytes in demyelinating lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Neurological autoimmune disease and the trimolecular complex of T-lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Human astrocytes are only partially competent antigen presenting cells. Possible implications for lesion development in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Astrocyte heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4,

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Anti?tumor necrosis factor therapy abrogates autoimmune demyelination

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Lymphokine production by encephalitogenic and non-encephalitogenic T-cell clones reactive to the same antigenic determinant

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Morphological changes in oligodendrocytes in the intact mouse optic nerve following intravitreal injection of tumour necrosis factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Effects of Interleukin-1 and Tumor Necrosis Factor-α on Astrocytes, Microglia, Oligodendrocytes, and Glial Precursors in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Serum and CSF levels of IL-2, sIL-2R, TNF-alpha, and IL-1 beta in chronic progressive multiple sclerosis: expected lack of clinical utility

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

In vitro study of mediators of inflammation in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Cytokine secretion by multiple sclerosis monocytes. Relationship to disease activity

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Cytokine localization in multiple sclerosis lesions: correlation with adhesion molecule expression and reactive nitrogen species

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Cytokines up-regulate Ia expression in organotypic cultures of central nervous system tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Multiple sclerosis: involvement of interferons in lesion pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor-alpha in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Oligoclonal IgG bands in plaques from multiple sclerosis brains.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Immune mechanisms in the pathogenesis of demyelinating diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Normal rat serum cytotoxicity against syngeneic oligodendrocytes. Complement activation and attack in the absence of anti-myelin antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Mechanisms of oligodendrocyte interaction with normal human serum - defining the role of complement

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

The immunogenesis of the multiple sclerosis plaque

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Terminal component of complement (C9) in cerebrospinal fluid of patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Terminal component of complement (C9) in the cerebrospinal fluid of patients with multiple sclerosis and neurologic controls

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

The Dale E. McFarlin Memorial Lecture: the immunology of the multiple sclerosis lesion

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Rachelle Fishman-Matthew Moore Lecture. The pathological and clinical dynamics of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Oligodendrocyte injury is an early event in lesions of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Electron microscopic features of multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Multiple sclerosis: remyelination of nascent lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Patterns of oligodendroglia pathology in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Immune promotion of central nervous system remyelination.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Immunosuppression promotes CNS remyelination in chronic virus‐induced demyelinating disease

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Immunoglobulins promote remyelination in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Monoclonal autoantibody SCH94.03, which promotes central nervous system remyelination, recognizes an antigen on the surface of oligodendrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Theiler's virus infection of beta 2-microglobulin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

Proteolipid protein gene expression in demyelination and remyelination of the central nervous system: a model for multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2963576-3

7 January 2021

10.1016/S0025-6196(11)63576-3

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DOI

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