(Q41562658)

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Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.

scientific article published on 30 August 2017

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29 March 2020

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity (English)

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29 March 2020

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29 March 2020

Kevin Tianmeng Zhao

2

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29 March 2020

Michael S Packer

3

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29 March 2020

Nicole M Gaudelli

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29 March 2020

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29 March 2020

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29 March 2020

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Amanda L Waterbury

5

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29 March 2020

Y Bill Kim

7

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29 March 2020

Ahmed H Badran

8

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29 March 2020

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30 August 2017

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29 March 2020

Science Advances

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29 March 2020

3

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29 March 2020

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29 March 2020

eaao4774

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29 March 2020

Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Engineering and optimising deaminase fusions for genome editing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

In vivo genome editing using Staphylococcus aureus Cas9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

DNA double strand break repair via non-homologous end-joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Structural basis for CRISPR RNA-guided DNA recognition by Cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Structure and function in the uracil-DNA glycosylase superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

6 June 2018

CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Highly efficient RNA-guided base editing in mouse embryos.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Precise Editing of a Target Base in the Rice Genome Using a Modified CRISPR/Cas9 System.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Patterns of chromosomal fragmentation due to uracil-DNA incorporation reveal a novel mechanism of replication-dependent double-stranded breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576876

19 August 2018

Identifiers

10.1126/SCIADV.AAO4774

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Europe PubMed Central

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29 March 2020

PMC publication ID

1 reference

Europe PubMed Central

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29 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

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29 March 2020

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