(Q41603966)

4 October 2017

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title

Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls (English)

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4 October 2017

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Davies NM

1

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PubMed ID

9314611

4 October 2017

Anderson KE

series ordinal

2

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4 October 2017

1 September 1997

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Clinical Pharmacokinetics

4 October 2017

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4 October 2017

33

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4 October 2017

184-213

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4 October 2017

3

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https://scigraph.springernature.com/pub.10.2165/00003088-199733030-00003

4 October 2017

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cites work

Biotransformation of diclofenac sodium (Voltaren) in animals and in man. I. Isolation and identification of principal metabolites

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12 December 2020

The efficacy and relative bioavailability of diclofenac resinate in rheumatoid arthritis patients

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12 December 2020

Cyclosporin and diclofenac interaction in rheumatoid arthritis

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12 December 2020

Potential pharmacokinetic interactions of nocloprost clathrate with retarded theophylline and enteric coated diclofenac after single and repeated premedication in healthy volunteers

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12 December 2020

A study on the relative bioavailability of a sustained-release formulation of diclofenac sodium

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12 December 2020

Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations

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12 December 2020

Sensitive capillary gas chromatographic-mass spectrometric-selected-ion monitoring method for the determination of diclofenac concentrations in human plasma

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12 December 2020

Analysis of diclofenac and four of its metabolites in human urine by HPLC

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12 December 2020

Pharmacokinetic Studies on Diclofenac Sodium in Young and Old Volunteers

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12 December 2020

Determination of diclofenac in human plasma by selected ion monitoring

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12 December 2020

Transdermal non-steroidal anti-inflammatory agents

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12 December 2020

Diaphragm disease of the ascending colon. Association with sustained-release diclofenac

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12 December 2020

The effects of cholestyramine and colestipol on the absorption of diclofenac in man

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12 December 2020

Nonsteroidal antiinflammatory drugs and cyclosporine. A potentially serious adverse interaction

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12 December 2020

Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once-daily administration of a 100 mg slow-release formulation

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12 December 2020

The pharmacokinetics and metabolism of diclofenac sodium (Voltarol) in animals and man

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12 December 2020

A new metabolite of diclofenac sodium in human plasma

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12 December 2020

[Quantitative determination of diclofenac sodium in plasma by absorption measurement by means of direct evaluation of thin layer chromatograms]

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12 December 2020

Determination of serum diclofenac by high-performance liquid chromatography by electromechanical detection.

1 reference

12 December 2020

Characterization of a novel diclofenac metabolite in human urine by capillary gas chromatography-negative chemical ionization mass spectrometry.

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12 December 2020

The effect of magnesium hydroxide on the oral absorption of ibuprofen, ketoprofen and diclofenac

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12 December 2020

Diclofenac binding to albumin and lipoproteins in human serum

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12 December 2020

Submicron emulsion vehicle for enhanced transdermal delivery of steroidal and nonsteroidal antiinflammatory drugs

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12 December 2020

Interactions between diclofenac and glibenclamide

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12 December 2020

The influence of ibuprofen, diclofenac and sulindac on the blood pressure lowering effect of hydrochlorothiazide.

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12 December 2020

Automated robotic extraction and subsequent analysis of diclofenac in plasma samples.

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12 December 2020

Improved gas chromatographic method of determining diclofenac in plasma

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12 December 2020

Pharmacokinetics and Metabolism of the Anti-Inflammatory Agent Voltaren

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12 December 2020

Diclofenac sodium: blood concentration of the slow-release form and influence on the metabolism of kallikrein

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12 December 2020

A comparative bioavailability study on two sustained-release formulations of diclofenac sodium following a single dose administration

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12 December 2020

[In vitro and in vivo studies of diclofenac suppositories in humans]

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12 December 2020

Synovial fluid concentrations of diclofenac in patients with rheumatoid arthritis or osteoarthritis

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12 December 2020

[Biological availability of gastric juice-resistant coated diclofenac preparations. 1. Bioavailability study following a single administration of a multiple-unit formulation in comparison with a single-unit formulation]

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12 December 2020

An automated method for the determination of diclofenac sodium in human plasma.

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12 December 2020

A case of diclofenac-induced colitis with focal granulomatous change

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12 December 2020

Effect of food and relative bioavailability following single doses of diclofenac 150 mg hydrogel bead (HGB) capsules in healthy humans

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12 December 2020

HPLC-determination of some antiinflammatory, weak analgesic and uricosuric drugs in human blood plasma and its application to pharmacokinetics

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12 December 2020

Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion

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12 December 2020

High-performance liquid chromatographic assay for antiinflammatory agents diclofenac and flurbiprofen in ocular fluids

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12 December 2020

Pharmacokinetics of rectal diclofenac and its hydroxy metabolites in man

1 reference

12 December 2020

Short-term sucralfate administration alters potassium diclofenac absorption in healthy male volunteers

1 reference

12 December 2020

Lack of effect of a single-dose of sulglicotide on the bioavailability of diclofenac

1 reference

12 December 2020

Local enhanced topical delivery (LETD) of drugs: does it truly exist?

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12 December 2020

The Analgesic Interaction of Misoprostol with Nonsteroidal Anti-Inflammatory Drugs.

1 reference

12 December 2020

Small bowel perforation associated with an excessive dose of slow release diclofenac sodium

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation

1 reference

12 December 2020

Human transbuccal absorption of diclofenac sodium from a prototype hydrogel delivery device

1 reference

12 December 2020

High-performance liquid chromatographic method for the routine determination of diclofenac and its hydroxy and methoxy metabolites from in vitro systems

1 reference

12 December 2020

Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis

1 reference

12 December 2020

Local tolerability and pharmacokinetic profile of a new transdermal delivery system, diclofenac hydroxyethylpyrrolidine plaster

1 reference

12 December 2020

Pharmacokinetics of diclofenac sodium using a developed HPLC method

1 reference

12 December 2020

The determination of non-steroidal antiinflammatory drugs in pharmaceuticals by capillary zone electrophoresis and micellar electrokinetic capillary chromatography.

1 reference

12 December 2020

Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis

1 reference

12 December 2020

The effect of diclofenac sodium on the metabolism of diabetics in qualitative diet therapy with an without tolbuamide. A clinically oriented study in aged diabetics with rheumatic disease

1 reference

12 December 2020

Simultaneous small and large bowel ulceration associated with short term NSAID use

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12 December 2020

Diclofenac, paracetamol, and vidarabine removal during plasma exchange in polyarteritis nodosa patients

1 reference

12 December 2020

A Cecal Diaphragm Associated with the Use of Nonsteroidal Anti-inflammatory Drugs

1 reference

12 December 2020

Colonic ulceration and bleeding during diclofenac therapy

1 reference

12 December 2020

High-performance liquid chromatographic determination of naproxen, ibuprofen and diclofenac in plasma and synovial fluid in man

1 reference

12 December 2020

Percutaneous absorption of diclofenac in healthy volunteers after single and repeated topical application of diclofenac Emulgel

1 reference

12 December 2020

NSAIDs and gut damage

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12 December 2020

Bioanalysis of diclofenac as its fluorescent carbazole acetic acid derivative by a post-column photoderivatization high-performance liquid chromatographic method

1 reference

12 December 2020

The influence of food on the absorption of diclofenac as determined by the urinary excretion of the unchanged drug and its major metabolites during chronic administration.

1 reference

12 December 2020

The pharmacokinetics of diclofenac sodium in patients with active rheumatoid disease

1 reference

12 December 2020

Nonsteroidal antiinflammatory drug-induced colonic strictures: a case report

1 reference

12 December 2020

Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver

1 reference

12 December 2020

[The percutaneous absorption of diclofenac]

1 reference

12 December 2020

Pharmacokinetics and drug input characteristics for a diclofenac-codeine phosphate combination following oral and rectal administration

1 reference

12 December 2020

[The bioavailability of enteric coated diclofenac formulations. 2. Bioavailability following single administration of a multiple-unit formulation in comparison to a single-unit formulation under fasting and non-fasting conditions]

1 reference

12 December 2020

Comparative bioavailability and in vitro characterization of two brands of diclofenac sodium enteric-coated tablets

1 reference

12 December 2020

Femtomole analysis of diclofenac in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry using (18O2) diclofenac as internal standard

1 reference

12 December 2020

[Segmental small intestine lesions after taking non-steroidal antirheumatic drugs]

1 reference

12 December 2020

The relative bioavailability of diclofenac with respect to time of administration

1 reference

12 December 2020

Application of radiotelemetric technique in evaluating diclofenac sodium absorption after oral administration of various dosage forms in healthy volunteers

1 reference

12 December 2020

Pharmacokinetics of intravenous diclofenac sodium in children

1 reference

12 December 2020

Transsynovial drug distribution: synovial mean transit time of diclofenac and other nonsteroidal antiinflammatory drugs

1 reference

12 December 2020

Disappearance kinetics of solutes from synovial fluid after intra-articular injection

1 reference

12 December 2020

Femtomole analysis of diclofenac in human plasma by gas chromatography/negative ion chemical ionization/mass spectrometry using (18O2)diclofenac as internal standard

1 reference

12 December 2020

A diclofenac derivative without ulcerogenic properties

1 reference

12 December 2020

The influence of food on the absorption of diclofenac as a pure substance

1 reference

12 December 2020

Plasma and synovial fluid interleukin-1, interleukin-6 and substance P concentrations in rheumatoid arthritis patients: effect of the nonsteroidal anti inflammatory drugs indomethacin, diclofenac and naproxen.

1 reference

12 December 2020

Extractionless determination of diclofenac sodium in serum using reversed-phase high-performance liquid chromatography with fluorimetric detection

1 reference

12 December 2020

Application of dual radiotelemetric technique in studying drug-drug interaction between diclofenac sodium and ranitidine HCl in volunteers

1 reference

12 December 2020

Diclofenac sodium (GP 45840, Voltaren), a potent inhibitor of prostaglandin synthetase

1 reference

12 December 2020

Biopharmaceutical profile of diclofenac-misoprostol combination tablet, Arthrotec

1 reference

12 December 2020

Comparative bioavailability of two suspension formulations of potassium diclofenac in healthy male volunteers

1 reference

12 December 2020

The influence of diclofenac sodium (Voltarol) on free, protein-bound and total plasma L-tryptophan in adult healthy male subjects

1 reference

12 December 2020

Simplified micromethod for the HPLC measurement of diclofenac in plasma

1 reference

12 December 2020

In-vitro and in-vivo studies of the diclofenac sodium controlled-release matrix tablets

1 reference

12 December 2020

The influence of food on the absorption of diclofenac after single and multiple oral doses.

1 reference

12 December 2020

Effect of Diclofenac on glucose tolerance of diabetic patients

1 reference

12 December 2020

[Anti-rheumatic therapy in patients with liver diseases. Plasma levels of diclofenac and elimination of diclofenac and metabolites in urine of patients with liver disease]

1 reference

12 December 2020

Determination of total monohydroxylated metabolites of diclofenac in urine by electron-capture gas-liquid chromatography

1 reference

12 December 2020

[Transport of sodium diclofenac into synovial fluid]

1 reference

12 December 2020

Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy

1 reference

12 December 2020

Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat

1 reference

12 December 2020

Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection

1 reference

12 December 2020

Comparative bioavailability of a dispersible formulation of diclofenac and finding of double plasma peaks.

1 reference

12 December 2020

Pharmacokinetics of diclofenac and five metabolites after single doses in healthy volunteers and after repeated doses in patients

1 reference

12 December 2020

Enhancement of cyclosporine A nephrotoxicity by diclofenac.

1 reference

12 December 2020

Comparative bioavailability of slow release diclofenac (Voveran SR) with enteric coated tablet and internationally used Voltaren Retard

1 reference

12 December 2020

[Potential interactions of diclofenac-sodium (Voltaren) with antibiotics]

1 reference

12 December 2020

Pharmacokinetic studies in healthy volunteers on a new gastroprotective pharmaceutic form of diclofenac

1 reference

12 December 2020

Quantitative assay of diclofenac in biological material by gas—liquid chromatography

1 reference

12 December 2020

Determination of diclofenac in plasma using a fully automated analytical system combining liquid-solid extraction with liquid chromatography

1 reference

12 December 2020

Pharmacokinetics of diclofenac sodium after intramuscular administration in combination with triamcinolone acetate

1 reference

12 December 2020

Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man

1 reference

12 December 2020

Markedly reduced intestinal toxicity of a diclofenac derivative

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic implications of long-term administration of non-steroidal anti-inflammatory agents

1 reference

12 December 2020

Treatment of Juvenile Rheumatoid Arthritis with Diclofenac Sodium

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12 December 2020

The bioavailability of diclofenac from enteric coated products in healthy volunteers with normal and artificially decreased gastric acidity

1 reference

12 December 2020

Determination of diclofenac and its metabolites in plasma and cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection

1 reference

12 December 2020

Separation and identification of non-steroidal antirheumatic drugs containing a free carboxyl function using high-performance liquid chromatography

1 reference

12 December 2020

Small bowel permeability--a variable effect of NSAIDS

1 reference

12 December 2020

Are right colonic lesions specific to sustained-release NSAID preparations?

1 reference

12 December 2020

Pharmacokinetics of cyclosporine and multiple-dose diclofenac during coadministration.

1 reference

12 December 2020

Comparative pharmacokinetic analysis of a novel sustained-release dosage form of diclofenac sodium in healthy subjects

1 reference

12 December 2020

A Double-Blind Clinical Trial to Determine if an Interaction Exists between Diclofenac Sodium and the Oral Anticoagulant Acenocoumarol (Nicoumalone)

1 reference

12 December 2020

Interaction between methotrexate and non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

Simultaneous determination of diclofenac sodium and its metabolites in plasma by capillary column gas chromatography with electron-capture detection

1 reference

12 December 2020

Biotransformation of Diclofenac Sodium (Voltaren®) in Animals and in Man.: II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile

1 reference

12 December 2020

Diclofenac concentrations in synovial fluid and plasma after cutaneous application in inflammatory and degenerative joint disease

1 reference

12 December 2020

Ocular diclofenac. A review of its pharmacology and clinical use in cataract surgery, and potential in other inflammatory ocular conditions

1 reference

12 December 2020

A study to determine the clinical relevance of the pharmacokinetic interaction between aspirin and diclofenac

1 reference

12 December 2020

Biliary elimination of non-steroidal anti-inflammatory drugs in patients

1 reference

12 December 2020

Pharmacokinetics of paracetamol, diclofenac and vidarabine during plasma exchange

1 reference

12 December 2020

A rapid and sensitive high-performance liquid chromatographic method for the determination of diclofenac sodium in serum and its use in pharmacokinetic studies.

1 reference

12 December 2020

Non-steroidal anti-inflammatory drug-induced jejunal and colonic diaphragm disease: a report of two cases

1 reference

12 December 2020

The pharmacokinetics of diclofenac sodium following intravenous and oral administration

1 reference

12 December 2020

Does Diclofenac modify oral anticoagulant therapy and platelet aggregation?

1 reference

12 December 2020

Quantitative determination of sodium-o-[(2,6-dichlorophenyl)-amino]phenylacetate (diclofenac) in human blood plasma or serum

1 reference

12 December 2020

[Diclofenac vs nimesulide in arthrosis. Plasma levels and clinical efficacy]

1 reference

12 December 2020

Pharmacological Properties of Diclofenac Sodium and Its Metabolites

1 reference

12 December 2020

Extractionless high-performance liquid chromatographic method for the determination of diclofenac in human plasma and urine

1 reference

12 December 2020

High-performance liquid chromatographic method for the determination of diclofenac and its hydroxy metabolites in human plasma and urine

1 reference

12 December 2020

Rapid high-performance liquid chromatographic assay for the simultaneous analysis of non-steroidal antiinflammatory drugs in plasma

1 reference

12 December 2020

Sensitive method for the determination of diclofenac in human plasma by gas chromatography-mass spectrometry

1 reference

12 December 2020

[Biologic availability of oral preparations of diclofenac]

1 reference

12 December 2020

The pharmacokinetics of a new sustained-release form of diclofenac sodium in humans

1 reference

12 December 2020

Methotrexate kinetics in rheumatoid arthritis: is there an interaction with nonsteroidal antiinflammatory drugs?

1 reference

12 December 2020

Determination of diclofenac in plasma and synovial fluid by high-performance liquid chromatography with electrochemical detection

1 reference

12 December 2020

Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin

1 reference

12 December 2020

Diclofenac combined with cyclosporine in treatment refractory rheumatoid arthritis: longitudinal safety assessment and evidence of a pharmacokinetic/dynamic interaction

1 reference

12 December 2020

In vitro protein binding of diclofenac sodium in plasma and synovial fluid

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drug-induced colonic strictures: two cases and literature review.

1 reference

12 December 2020

Ileo-caecal ulceration associated with the use of diclofenac slow release

1 reference

12 December 2020

Non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

A study of the effect of aspirin on the pharmacokinetics of oral and intravenous diclofenac sodium

1 reference

12 December 2020

Colonoscopy in the investigation of drug absorption in healthy volunteers

1 reference

12 December 2020

Evaluation of the gastric absorption and emptying of drugs under various pH conditions using a simple intubation method: application to diclofenac

1 reference

12 December 2020

Pharmacokinetics of Diclofenac Sodium (Voltaren) And Metabolites in Patients with Impaired Renal Function

1 reference

12 December 2020

[High-performance liquid chromatographic method for the determination of diclofenac in serum and its pharmacokinetics in healthy volunteers]

1 reference

12 December 2020

Detection and quantification of non-steroidal anti-inflammatory agents by gas chromatography/mass spectrometry: diclofenac

1 reference

12 December 2020

Intraocular diclofenac and flurbiprofen concentrations in human aqueous humor following topical application

1 reference

12 December 2020

Effects of diclofenac on lithium kinetics

1 reference

12 December 2020

Lecithin Organogel as Matrix for Transdermal Transport of Drugs

1 reference

12 December 2020

Comparative pharmacokinetics and bioavailability study of percutaneous absorption of diclofenac from two topical formulations containing drug as a solution gel or as an emulsion gel

1 reference

12 December 2020

Factors affecting the pharmacokinetics of diclofenac sodium (Voltarol)

1 reference

12 December 2020

Comparative pharmacokinetic evaluation of compressed suppositories of diclofenac sodium in humans

1 reference

12 December 2020

Comparative bioavailability of two tablet formulations of diclofenac sodium in normal subjects

1 reference

12 December 2020

Skin permeability and local tissue concentrations of nonsteroidal anti-inflammatory drugs after topical application

1 reference

12 December 2020

10.2165/00003088-199733030-00003

Identifiers

DOI

1 reference

PubMed ID

9314611

Dimensions Publication ID

4 October 2017

0 references

1 reference

PubMed ID

9314611