(Q41643468)

English

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

scientific article published on January 22, 1992

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 October 2017

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells (English)

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10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

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10.1016/0006-2952(92)90274-M

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13 November 2022

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10.1016/0006-2952(92)90274-M

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13 November 2022

author name string

R. J. Riley

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1739405

13 November 2022

P. Workman

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1739405

13 November 2022

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1 January 1992

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6 October 2017

22 January 1992

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1739405

13 November 2022

full work available at URL

https://api.elsevier.com/content/article/PII:000629529290274M?httpAccept=text/xml

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13 November 2022

https://api.elsevier.com/content/article/PII:000629529290274M?httpAccept=text/plain

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13 November 2022

Biochemical Pharmacology

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6 October 2017

43

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6 October 2017

2

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6 October 2017

167-174

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6 October 2017

Hypoxia in tumors: a paradigm for the approach to biochemical and physiologic heterogeneity

1

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10.1016/0006-2952(92)90274-M

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The hypoxic tumor cell: a target for selective cancer chemotherapy

5

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SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

7

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10.1016/0006-2952(92)90274-M

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13 November 2022

Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233

8

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10.1016/0006-2952(92)90274-M

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13 November 2022

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin

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10.1016/0006-2952(92)90274-M

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Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)

13

1 reference

10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide

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10.1016/0006-2952(92)90274-M

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13 November 2022

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

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10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines

16

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10.1016/0006-2952(92)90274-M

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13 November 2022

SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures

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10.1016/0006-2952(92)90274-M

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13 November 2022

Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations.

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10.1016/0006-2952(92)90274-M

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13 November 2022

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

20

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10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

21

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10.1016/0006-2952(92)90274-M

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13 November 2022

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

23

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13 November 2022

High-performance liquid chromatographic assay for the benzotriazine di-N-oxide (SR 4233) and its reduced metabolites in biological materials

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10.1016/0006-2952(92)90274-M

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6 Statistical analysis of enzyme kinetic data

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10.1016/0006-2952(92)90274-M

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Rat liver DT-diaphorase as a nitroso-reductase

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10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

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10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

30

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10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol

31

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10.1016/0006-2952(92)90274-M

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13 November 2022

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells

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10.1016/0006-2952(92)90274-M

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13 November 2022

Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma

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10.1016/0006-2952(92)90274-M

https://api.crossref.org/works/10.1016/0006-2952(92)90274-M

13 November 2022

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H: (quinone-acceptor)oxidoreductase

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13 November 2022

Electrochemical studies and DNA damaging effects of the benzotriazine-N-oxides

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10.1016/0006-2952(92)90274-M

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13 November 2022

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10.1016/0006-2952(92)90274-M

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

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