(Q41660129)

English

Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver.

scientific article published on 10 September 2012

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23552841%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver (English)

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27 February 2020

Nikolaus Schultz

2

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27 February 2020

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S A Comerford

1

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27 February 2020

E A Hinnant

3

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27 February 2020

S Klapproth

4

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27 February 2020

R E Hammer

5

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27 February 2020

publication date

10 September 2012

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27 February 2020

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27 February 2020

1

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27 February 2020

e28

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27 February 2020

miR-34 miRNAs provide a barrier for somatic cell reprogramming

1 reference

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6 June 2018

p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Simian virus 40 T-antigen-mediated gene regulation in enterocytes is controlled primarily by the Rb-E2F pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

T antigen transgenic mouse models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Cell-type specific regulation of gene expression by simian virus 40 T antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

SV40: Cell transformation and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Epigenetic reprogramming by adenovirus e1a.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Adenovirus small e1a alters global patterns of histone modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Simian virus 40 large T overcomes p300 repression of c-Myc.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Elucidation of a universal size-control mechanism in Drosophila and mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

New cell surface markers for murine fetal hepatic stem cells identified through high density complementary DNA microarrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Reactome: a knowledge base of biologic pathways and processes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Serum markers of hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

The P53 pathway: what questions remain to be explored?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

p53 targets simian virus 40 large T antigen for acetylation by CBP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

SV40 17KT antigen complements dnaj mutations in large T antigen to restore transformation of primary human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

p53 targets chromatin structure alteration to repress alpha-fetoprotein gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Role of T antigen interactions with p53 in tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

The H19 TATA-less promoter is efficiently repressed by wild-type tumor suppressor gene product p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Association of p300 and CBP with simian virus 40 large T antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

SV40 T antigen abrogates p53-mediated transcriptional activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Overproduction of protein p53 contributes to simian virus 40-mediated transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Cell lineages and oval cell progenitors in rat liver development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

Spliced early mRNAs of simian virus 40

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

6 June 2018

RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

18 August 2018

A CD133-expressing murine liver oval cell population with bilineage potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

18 August 2018

An amylase/Cre transgene marks the whole endoderm but the primordia of liver and ventral pancreas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

18 August 2018

Induction of hepatocyte proliferation and death by modulation of T-Antigen expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

18 August 2018

An unexpected role for p53 in augmenting SV40 large T antigen-mediated tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503294

18 August 2018

Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FONCSIS.2012.27

31 March 2020

Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy

1 reference

https://api.crossref.org/works/10.1038%2FONCSIS.2012.27

31 March 2020

The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice

1 reference

https://api.crossref.org/works/10.1038%2FONCSIS.2012.27

31 March 2020

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

2 references

https://api.crossref.org/works/10.1038%2FONCSIS.2012.27

31 March 2020

https://pubmed.ncbi.nlm.nih.gov/23552841

12 December 2020

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10.1038/ONCSIS.2012.27

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23552841%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23552841%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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27 February 2020

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